Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/21/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AIRE", "attributes": { "go_molecular_function": [ "metal ion binding", "protein binding", "DNA binding", "identical protein binding" ], "pathway_id": [ "kegg_path:hsa04120", "kegg_path:hsa05340" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O43918", "ensembl_id": "ENSG00000160224", "entrez_id": "326", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.543718" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "52" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AIRE/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AIRE/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "21" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AIRE/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AIRE/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AIRE/?format=api" } }, { "type": "Gene", "id": "IRF8", "attributes": { "go_molecular_function": [ "transcription cis-regulatory region binding", "DNA-binding transcription repressor activity, RNA polymerase II-specific", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "sequence-specific double-stranded DNA binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "DNA-binding transcription factor activity" ], "pathway_id": [ "R-HSA-909733", "R-HSA-913531", "R-HSA-1280215", "R-HSA-168256", "kegg_path:hsa05133", "R-HSA-877300" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q02556", "ensembl_id": "ENSG00000140968", "entrez_id": "3394", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.897366" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "53" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IRF8/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IRF8/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "21" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IRF8/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IRF8/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IRF8/?format=api" } }, { "type": "Gene", "id": "LRBA", "attributes": { "go_molecular_function": [ "['molecular_function', 'protein kinase binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "P50851", "ensembl_id": "None", "entrez_id": "ENSG00000198589", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.666340" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "51" }, { "type": "SmallVariant", "id": "3633" }, { "type": "SmallVariant", "id": "3646" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRBA/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRBA/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "21" }, { "type": "GeneCombination", "id": "1222" }, { "type": "GeneCombination", "id": "1228" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRBA/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRBA/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LRBA/?format=api" } }, { "type": "Gene", "id": "LYST", "attributes": { "go_molecular_function": [], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "A0A0A0MRZ6", "ensembl_id": "ENSG00000143669", "entrez_id": "1130", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.647383" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "50" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LYST/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LYST/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "21" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LYST/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LYST/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LYST/?format=api" } }, { "type": "Gene", "id": "STXBP2", "attributes": { "go_molecular_function": [ "syntaxin-3 binding", "syntaxin-1 binding", "protein binding", "syntaxin binding" ], "pathway_id": [ "R-HSA-449147", "R-HSA-168256", "R-HSA-449836", "R-HSA-76005", "R-HSA-1280215", "R-HSA-76002", "R-HSA-109582", "R-HSA-114608" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q15833", "ensembl_id": "ENSG00000076944", "entrez_id": "6813", "chromosome_number": "19", "lastmodified": "2021-10-18T11:00:44.963670" }, "relationships": { "variant_set": { "meta": { "count": 11 }, "data": [ { "type": "SmallVariant", "id": "1132" }, { "type": "SmallVariant", "id": "49" }, { "type": "SmallVariant", "id": "106" }, { "type": "SmallVariant", "id": "114" }, { "type": "SmallVariant", "id": "1125" }, { "type": "SmallVariant", "id": "1127" }, { "type": "SmallVariant", "id": "1128" }, { "type": "SmallVariant", "id": "1129" }, { "type": "SmallVariant", "id": "1130" }, { "type": "SmallVariant", "id": "1134" }, { "type": "SmallVariant", "id": "1137" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/STXBP2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/STXBP2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "21" }, { "type": "GeneCombination", "id": "37" }, { "type": "GeneCombination", "id": "41" }, { "type": "GeneCombination", "id": "363" }, { "type": "GeneCombination", "id": "364" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/STXBP2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/STXBP2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/STXBP2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }