Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/220/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ADGRB2", "attributes": { "go_molecular_function": [ "G protein-coupled receptor activity", "protein binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O60241", "ensembl_id": "ENSG00000121753", "entrez_id": "576", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.795251" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "673" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADGRB2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADGRB2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "220" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADGRB2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADGRB2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ADGRB2/?format=api" } }, { "type": "Gene", "id": "CACNA1H", "attributes": { "go_molecular_function": [ "['low voltage-gated calcium channel activity', 'voltage-gated ion channel activity', 'voltage-gated sodium channel activity', 'protein binding', 'metal ion binding', 'scaffold protein binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04020", "kegg_path:hsa04713", "kegg_path:hsa04925", "kegg_path:hsa04927", "kegg_path:hsa04929", "kegg_path:hsa04934", "R-HSA-1266738", "R-HSA-375165", "R-HSA-419037", "R-HSA-422475", "R-HSA-9675108" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O95180", "ensembl_id": "None", "entrez_id": "ENSG00000196557", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.379820" }, "relationships": { "variant_set": { "meta": { "count": 8 }, "data": [ { "type": "SmallVariant", "id": "653" }, { "type": "SmallVariant", "id": "674" }, { "type": "SmallVariant", "id": "690" }, { "type": "SmallVariant", "id": "1163" }, { "type": "SmallVariant", "id": "2061" }, { "type": "SmallVariant", "id": "2070" }, { "type": "SmallVariant", "id": "3065" }, { "type": "SmallVariant", "id": "3091" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA1H/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CACNA1H/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "220" }, { "type": "GeneCombination", "id": "222" }, { "type": "GeneCombination", "id": "373" }, { "type": "GeneCombination", "id": "711" }, { "type": "GeneCombination", "id": "715" }, { "type": "GeneCombination", "id": "1036" }, { "type": "GeneCombination", "id": "1028" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA1H/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CACNA1H/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA1H/?format=api" } }, { "type": "Gene", "id": "CHRNB1", "attributes": { "go_molecular_function": [ "ligand-gated ion channel activity", "protein binding", "acetylcholine binding", "acetylcholine-gated cation-selective channel activity" ], "pathway_id": [ "kegg_path:hsa04080" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P11230", "ensembl_id": "ENSG00000170175", "entrez_id": "1140", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.529989" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "675" }, { "type": "SmallVariant", "id": "676" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CHRNB1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CHRNB1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "220" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CHRNB1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CHRNB1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CHRNB1/?format=api" } }, { "type": "Gene", "id": "GALC", "attributes": { "go_molecular_function": [ "galactosylceramidase activity" ], "pathway_id": [ "kegg_path:hsa00600", "kegg_path:hsa04142", "R-HSA-1430728", "R-HSA-1660662", "R-HSA-428157", "kegg_path:hsa01100", "R-HSA-556833" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P54803", "ensembl_id": "ENSG00000054983", "entrez_id": "2581", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.752228" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "677" }, { "type": "SmallVariant", "id": "696" }, { "type": "SmallVariant", "id": "1999" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GALC/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GALC/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "220" }, { "type": "GeneCombination", "id": "223" }, { "type": "GeneCombination", "id": "688" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GALC/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GALC/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GALC/?format=api" } }, { "type": "Gene", "id": "HTT", "attributes": { "go_molecular_function": [ "protein binding", "identical protein binding" ], "pathway_id": [ "R-HSA-74160", "kegg_path:hsa05022", "kegg_path:hsa05016", "R-HSA-73857", "R-HSA-8986944", "R-HSA-9022692", "R-HSA-212436" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P42858", "ensembl_id": "ENSG00000197386", "entrez_id": "3064", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.849810" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "678" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HTT/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HTT/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "220" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HTT/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HTT/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HTT/?format=api" } }, { "type": "Gene", "id": "ITPR1", "attributes": { "go_molecular_function": [ "phosphatidylinositol binding", "inositol 1,4,5 trisphosphate binding", "protein binding", "calcium ion binding", "calcium-release channel activity", "inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity" ], "pathway_id": [ "kegg_path:hsa04621", "R-HSA-983705", "R-HSA-195721", "kegg_path:hsa04723", "R-HSA-372790", "R-HSA-9006925", "R-HSA-3858494", "R-HSA-418457", "R-HSA-2871809", "R-HSA-5578775", "kegg_path:hsa04921", "R-HSA-163685", "kegg_path:hsa04912", "kegg_path:hsa04210", "kegg_path:hsa04611", "kegg_path:hsa04726", "kegg_path:hsa04020", "R-HSA-162582", "kegg_path:hsa04925", "kegg_path:hsa05022", "R-HSA-9664323", "R-HSA-983695", "kegg_path:hsa05131", "kegg_path:hsa04724", "R-HSA-2029485", "R-HSA-9658195", "kegg_path:hsa04218", "kegg_path:hsa05205", "R-HSA-139853", "R-HSA-418594", "R-HSA-5663205", "kegg_path:hsa04371", "kegg_path:hsa04725", "kegg_path:hsa04728", "R-HSA-392154", "R-HSA-418346", "kegg_path:hsa04922", "kegg_path:hsa04928", "kegg_path:hsa05163", "R-HSA-5576891", "R-HSA-9664433", "R-HSA-416476", "R-HSA-112040", "R-HSA-112043", "kegg_path:hsa04972", "R-HSA-381676", "kegg_path:hsa04927", "R-HSA-1489509", "R-HSA-418360", "R-HSA-422356", "R-HSA-1280218", "R-HSA-168249", "R-HSA-5621481", "kegg_path:hsa04935", "kegg_path:hsa04270", "kegg_path:hsa04713", "kegg_path:hsa04970", "R-HSA-1643685", "R-HSA-109582", "kegg_path:hsa04114", "kegg_path:hsa04625", "kegg_path:hsa04730", "kegg_path:hsa04720", "kegg_path:hsa05167", "R-HSA-5607763", "R-HSA-9006934", "R-HSA-76002", "kegg_path:hsa04750", "kegg_path:hsa05016", "R-HSA-2454202", "kegg_path:hsa05017", "R-HSA-9662851", "kegg_path:hsa04924", "kegg_path:hsa04022", "R-HSA-194138", "R-HSA-4086398", "R-HSA-114508", "kegg_path:hsa04934", "R-HSA-111885", "R-HSA-168256", "kegg_path:hsa04140", "kegg_path:hsa04929", "R-HSA-388396", "R-HSA-5607764", "R-HSA-397014", "kegg_path:hsa04918", "kegg_path:hsa04971", "R-HSA-2029480", "kegg_path:hsa05170", "R-HSA-1430728", "kegg_path:hsa05012", "kegg_path:hsa04070", "kegg_path:hsa05010", "kegg_path:hsa05020", "kegg_path:hsa04540", "kegg_path:hsa04915", "R-HSA-4420097", "R-HSA-5218921" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q14643", "ensembl_id": "ENSG00000150995", "entrez_id": "3708", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.563079" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "670" }, { "type": "SmallVariant", "id": "679" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ITPR1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ITPR1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "219" }, { "type": "GeneCombination", "id": "220" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ITPR1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ITPR1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ITPR1/?format=api" } }, { "type": "Gene", "id": "SOD1", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'small GTPase binding', 'superoxide dismutase activity', 'protein binding', 'protein phosphatase 2B binding', 'copper ion binding', 'chaperone binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04146", "kegg_path:hsa04213", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05020", "kegg_path:hsa05022", "R-HSA-109582", "R-HSA-114608", "R-HSA-1280215", "R-HSA-168256", "R-HSA-2262752", "R-HSA-3299685", "R-HSA-447115", "R-HSA-449147", "R-HSA-76002", "R-HSA-76005", "R-HSA-8950505", "R-HSA-8953897", "R-HSA-9020591" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P00441", "ensembl_id": "None", "entrez_id": "ENSG00000142168", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.427208" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "1693" }, { "type": "SmallVariant", "id": "525" }, { "type": "SmallVariant", "id": "527" }, { "type": "SmallVariant", "id": "541" }, { "type": "SmallVariant", "id": "638" }, { "type": "SmallVariant", "id": "693" }, { "type": "SmallVariant", "id": "936" }, { "type": "SmallVariant", "id": "937" }, { "type": "SmallVariant", "id": "1379" }, { "type": "SmallVariant", "id": "1428" }, { "type": "SmallVariant", "id": "1709" }, { "type": "SmallVariant", "id": "2035" }, { "type": "SmallVariant", "id": "2039" }, { "type": "SmallVariant", "id": "2050" }, { "type": "SmallVariant", "id": "2189" }, { "type": "SmallVariant", "id": "3418" }, { "type": "SmallVariant", "id": "3426" }, { "type": "SmallVariant", "id": "3432" }, { "type": "SmallVariant", "id": "3446" }, { "type": "SmallVariant", "id": "3600" }, { "type": "SmallVariant", "id": "3603" }, { "type": "SmallVariant", "id": "3605" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 36 }, "data": [ { "type": "GeneCombination", "id": "173" }, { "type": "GeneCombination", "id": "174" }, { "type": "GeneCombination", "id": "184" }, { "type": "GeneCombination", "id": "216" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "219" }, { "type": "GeneCombination", "id": "220" }, { "type": "GeneCombination", "id": "221" }, { "type": "GeneCombination", "id": "222" }, { "type": "GeneCombination", "id": "223" }, { "type": "GeneCombination", "id": "297" }, { "type": "GeneCombination", "id": "298" }, { "type": "GeneCombination", "id": "434" }, { "type": "GeneCombination", "id": "451" }, { "type": "GeneCombination", "id": "552" }, { "type": "GeneCombination", "id": "559" }, { "type": "GeneCombination", "id": "561" }, { "type": "GeneCombination", "id": "562" }, { "type": "GeneCombination", "id": "699" }, { "type": "GeneCombination", "id": "700" }, { "type": "GeneCombination", "id": "701" }, { "type": "GeneCombination", "id": "702" }, { "type": "GeneCombination", "id": "706" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "723" }, { "type": "GeneCombination", "id": "722" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "747" }, { "type": "GeneCombination", "id": "1151" }, { "type": "GeneCombination", "id": "1154" }, { "type": "GeneCombination", "id": "1158" }, { "type": "GeneCombination", "id": "1212" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/?format=api" } }, { "type": "Gene", "id": "XK", "attributes": { "go_molecular_function": [ "transporter activity", "protein binding" ], "pathway_id": [ "R-HSA-373076", "R-HSA-500792", "R-HSA-162582", "R-HSA-372790", "R-HSA-375276", "R-HSA-162582", "R-HSA-372790", "R-HSA-500792", "R-HSA-373076", "R-HSA-375276" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P51811", "ensembl_id": "ENSG00000047597", "entrez_id": "7504", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.275494" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "680" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/XK/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/XK/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "220" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/XK/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/XK/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/XK/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 8 } }