Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/961/genes/?format=api
{ "data": [ { "type": "Gene", "id": "KL", "attributes": { "go_molecular_function": [ "['beta-glucuronidase activity', 'fibroblast growth factor binding', 'hormone activity', 'beta-glucosidase activity', 'fibroblast growth factor receptor binding', 'vitamin D binding']" ], "pathway_id": [ "kegg_path:hsa00040", "kegg_path:hsa00053", "kegg_path:hsa01100", "kegg_path:hsa04211", "kegg_path:hsa04928", "kegg_path:hsa04961" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9UEF7", "ensembl_id": "None", "entrez_id": "ENSG00000133116", "chromosome_number": "13", "lastmodified": "2021-10-18T11:00:44.898359" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1791" }, { "type": "SmallVariant", "id": "2900" }, { "type": "SmallVariant", "id": "2944" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KL/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KL/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "593" }, { "type": "GeneCombination", "id": "961" }, { "type": "GeneCombination", "id": "979" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KL/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KL/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/KL/?format=api" } }, { "type": "Gene", "id": "POLR3B", "attributes": { "go_molecular_function": [ "[\"DNA-directed 5'-3' RNA polymerase activity\", 'DNA binding', 'metal ion binding', 'ribonucleoside binding']" ], "pathway_id": [ "kegg_path:hsa03020", "kegg_path:hsa04623", "R-HSA-168249", "R-HSA-168256", "R-HSA-1834949", "R-HSA-73780", "R-HSA-73980", "R-HSA-74158", "R-HSA-74160", "R-HSA-749476", "R-HSA-76046", "R-HSA-76061", "R-HSA-76066", "R-HSA-76071" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9NW08", "ensembl_id": "None", "entrez_id": "ENSG00000013503", "chromosome_number": "12", "lastmodified": "2023-05-16T12:02:33.092625" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2898" }, { "type": "SmallVariant", "id": "2899" }, { "type": "SmallVariant", "id": "2927" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POLR3B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POLR3B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "961" }, { "type": "GeneCombination", "id": "972" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POLR3B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POLR3B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/POLR3B/?format=api" } }, { "type": "Gene", "id": "TBC1D20", "attributes": { "go_molecular_function": [ "['small GTPase binding', 'protein binding', 'GTPase activator activity']" ], "pathway_id": [ "R-HSA-199977", "R-HSA-199991", "R-HSA-204005", "R-HSA-392499", "R-HSA-446203", "R-HSA-5653656", "R-HSA-597592", "R-HSA-8854214", "R-HSA-9007101", "R-HSA-948021" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96BZ9", "ensembl_id": "None", "entrez_id": "ENSG00000125875", "chromosome_number": "20", "lastmodified": "2023-05-16T12:02:33.087092" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2897" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TBC1D20/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TBC1D20/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "961" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TBC1D20/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TBC1D20/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TBC1D20/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }