Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1000/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AMH", "attributes": { "go_molecular_function": [ "['growth factor activity', 'hormone activity', 'protein binding', 'type II transforming growth factor beta receptor binding', 'signaling receptor binding']" ], "pathway_id": [ "kegg_path:hsa04024", "kegg_path:hsa04060", "kegg_path:hsa04350", "kegg_path:hsa04390", "R-HSA-1266738", "R-HSA-162582", "R-HSA-201451", "R-HSA-9006936", "R-HSA-9690406" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P03971", "ensembl_id": "None", "entrez_id": "ENSG00000104899", "chromosome_number": "19", "lastmodified": "2021-10-18T11:00:44.744857" }, "relationships": { "variant_set": { "meta": { "count": 11 }, "data": [ { "type": "SmallVariant", "id": "1444" }, { "type": "SmallVariant", "id": "2445" }, { "type": "SmallVariant", "id": "2447" }, { "type": "SmallVariant", "id": "2449" }, { "type": "SmallVariant", "id": "2919" }, { "type": "SmallVariant", "id": "2940" }, { "type": "SmallVariant", "id": "2965" }, { "type": "SmallVariant", "id": "2996" }, { "type": "SmallVariant", "id": "3280" }, { "type": "SmallVariant", "id": "3309" }, { "type": "SmallVariant", "id": "3332" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AMH/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AMH/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "460" }, { "type": "GeneCombination", "id": "824" }, { "type": "GeneCombination", "id": "825" }, { "type": "GeneCombination", "id": "826" }, { "type": "GeneCombination", "id": "968" }, { "type": "GeneCombination", "id": "978" }, { "type": "GeneCombination", "id": "987" }, { "type": "GeneCombination", "id": "1000" }, { "type": "GeneCombination", "id": "1104" }, { "type": "GeneCombination", "id": "1113" }, { "type": "GeneCombination", "id": "1124" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AMH/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AMH/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AMH/?format=api" } }, { "type": "Gene", "id": "ANOS1", "attributes": { "go_molecular_function": [ "['heparin binding', 'extracellular matrix structural constituent', 'serine-type endopeptidase inhibitor activity', 'protein binding']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-190236", "R-HSA-190242", "R-HSA-190373", "R-HSA-5654726", "R-HSA-5654736", "R-HSA-9006934" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P23352", "ensembl_id": "None", "entrez_id": "ENSG00000011201", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.754255" }, "relationships": { "variant_set": { "meta": { "count": 36 }, "data": [ { "type": "CopyNumberVariant", "id": "3399" }, { "type": "CopyNumberVariant", "id": "1795" }, { "type": "CopyNumberVariant", "id": "1867" }, { "type": "SmallVariant", "id": "245" }, { "type": "SmallVariant", "id": "309" }, { "type": "SmallVariant", "id": "399" }, { "type": "SmallVariant", "id": "559" }, { "type": "SmallVariant", "id": "777" }, { "type": "SmallVariant", "id": "849" }, { "type": "SmallVariant", "id": "855" }, { "type": "SmallVariant", "id": "973" }, { "type": "SmallVariant", "id": "975" }, { "type": "SmallVariant", "id": "1083" }, { "type": "SmallVariant", "id": "1832" }, { "type": "SmallVariant", "id": "1833" }, { "type": "SmallVariant", "id": "1863" }, { "type": "SmallVariant", "id": "1876" }, { "type": "SmallVariant", "id": "1927" }, { "type": "SmallVariant", "id": "2202" }, { "type": "SmallVariant", "id": "2395" }, { "type": "SmallVariant", "id": "2405" }, { "type": "SmallVariant", "id": "2710" }, { "type": "SmallVariant", "id": "2727" }, { "type": "SmallVariant", "id": "2731" }, { "type": "SmallVariant", "id": "2767" }, { "type": "SmallVariant", "id": "2827" }, { "type": "SmallVariant", "id": "2916" }, { "type": "SmallVariant", "id": "2947" }, { "type": "SmallVariant", "id": "2957" }, { "type": "SmallVariant", "id": "2962" }, { "type": "SmallVariant", "id": "2966" }, { "type": "SmallVariant", "id": "2987" }, { "type": "SmallVariant", "id": "2988" }, { "type": "SmallVariant", "id": "2993" }, { "type": "SmallVariant", "id": "2997" }, { "type": "SmallVariant", "id": "3158" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ANOS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ANOS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 29 }, "data": [ { "type": "GeneCombination", "id": "191" }, { "type": "GeneCombination", "id": "264" }, { "type": "GeneCombination", "id": "261" }, { "type": "GeneCombination", "id": "354" }, { "type": "GeneCombination", "id": "594" }, { "type": "GeneCombination", "id": "620" }, { "type": "GeneCombination", "id": "623" }, { "type": "GeneCombination", "id": "624" }, { "type": "GeneCombination", "id": "642" }, { "type": "GeneCombination", "id": "651" }, { "type": "GeneCombination", "id": "901" }, { "type": "GeneCombination", "id": "907" }, { "type": "GeneCombination", "id": "312" }, { "type": "GeneCombination", "id": "90" }, { "type": "GeneCombination", "id": "243" }, { "type": "GeneCombination", "id": "968" }, { "type": "GeneCombination", "id": "969" }, { "type": "GeneCombination", "id": "975" }, { "type": "GeneCombination", "id": "981" }, { "type": "GeneCombination", "id": "984" }, { "type": "GeneCombination", "id": "986" }, { "type": "GeneCombination", "id": "988" }, { "type": "GeneCombination", "id": "992" }, { "type": "GeneCombination", "id": "997" }, { "type": "GeneCombination", "id": "998" }, { "type": "GeneCombination", "id": "1000" }, { "type": "GeneCombination", "id": "1001" }, { "type": "GeneCombination", "id": "1054" }, { "type": "GeneCombination", "id": "1088" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ANOS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ANOS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ANOS1/?format=api" } }, { "type": "Gene", "id": "AXL", "attributes": { "go_molecular_function": [ "['protein tyrosine kinase activity', 'myosin heavy chain binding', 'ATP binding', 'protein binding', 'phosphatidylserine binding', 'virus receptor activity', 'protein serine/threonine/tyrosine kinase activity', 'phosphatidylinositol 3-kinase binding', 'transmembrane receptor protein tyrosine kinase activity']" ], "pathway_id": [ "kegg_path:hsa01521", "R-HSA-162582", "R-HSA-194138", "R-HSA-4420097", "R-HSA-9006934" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P30530", "ensembl_id": "None", "entrez_id": "ENSG00000167601", "chromosome_number": "19", "lastmodified": "2021-10-18T11:00:44.989492" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "902" }, { "type": "SmallVariant", "id": "903" }, { "type": "SmallVariant", "id": "1849" }, { "type": "SmallVariant", "id": "1923" }, { "type": "SmallVariant", "id": "1942" }, { "type": "SmallVariant", "id": "1952" }, { "type": "SmallVariant", "id": "2995" }, { "type": "SmallVariant", "id": "3007" }, { "type": "SmallVariant", "id": "3371" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AXL/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AXL/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "281" }, { "type": "GeneCombination", "id": "282" }, { "type": "GeneCombination", "id": "614" }, { "type": "GeneCombination", "id": "649" }, { "type": "GeneCombination", "id": "665" }, { "type": "GeneCombination", "id": "1000" }, { "type": "GeneCombination", "id": "280" }, { "type": "GeneCombination", "id": "1130" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AXL/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AXL/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AXL/?format=api" } }, { "type": "Gene", "id": "FGF8", "attributes": { "go_molecular_function": [ "['growth factor activity', 'fibroblast growth factor receptor binding', 'type 2 fibroblast growth factor receptor binding', 'type 1 fibroblast growth factor receptor binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04151", "kegg_path:hsa04810", "kegg_path:hsa05200", "kegg_path:hsa05218", "kegg_path:hsa05224", "kegg_path:hsa05226", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04151", "kegg_path:hsa04810", "kegg_path:hsa05200", "kegg_path:hsa05218", "kegg_path:hsa05224", "kegg_path:hsa05226" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P55075", "ensembl_id": "None", "entrez_id": "ENSG00000107831", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.458626" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "385" }, { "type": "SmallVariant", "id": "859" }, { "type": "SmallVariant", "id": "880" }, { "type": "SmallVariant", "id": "1715" }, { "type": "SmallVariant", "id": "2709" }, { "type": "SmallVariant", "id": "2734" }, { "type": "SmallVariant", "id": "2824" }, { "type": "SmallVariant", "id": "2994" }, { "type": "SmallVariant", "id": "3374" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGF8/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGF8/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "131" }, { "type": "GeneCombination", "id": "900" }, { "type": "GeneCombination", "id": "910" }, { "type": "GeneCombination", "id": "941" }, { "type": "GeneCombination", "id": "1000" }, { "type": "GeneCombination", "id": "1132" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGF8/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGF8/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FGF8/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }