Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/185/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ATXN2", "attributes": { "go_molecular_function": [ "RNA binding", "protein C-terminus binding", "protein binding", "epidermal growth factor receptor binding" ], "pathway_id": [ "kegg_path:hsa05014", "kegg_path:hsa05017", "kegg_path:hsa05022" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q99700", "ensembl_id": "ENSG00000204842", "entrez_id": "6311", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.703597" }, "relationships": { "variant_set": { "meta": { "count": 8 }, "data": [ { "type": "CopyNumberVariant", "id": "535" }, { "type": "CopyNumberVariant", "id": "1226" }, { "type": "CopyNumberVariant", "id": "1370" }, { "type": "CopyNumberVariant", "id": "1725" }, { "type": "CopyNumberVariant", "id": "2063" }, { "type": "CopyNumberVariant", "id": "2065" }, { "type": "CopyNumberVariant", "id": "2067" }, { "type": "CopyNumberVariant", "id": "2069" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATXN2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATXN2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "179" }, { "type": "GeneCombination", "id": "182" }, { "type": "GeneCombination", "id": "185" }, { "type": "GeneCombination", "id": "390" }, { "type": "GeneCombination", "id": "428" }, { "type": "GeneCombination", "id": "567" }, { "type": "GeneCombination", "id": "568" }, { "type": "GeneCombination", "id": "712" }, { "type": "GeneCombination", "id": "713" }, { "type": "GeneCombination", "id": "714" }, { "type": "GeneCombination", "id": "715" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATXN2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATXN2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ATXN2/?format=api" } }, { "type": "Gene", "id": "DCTN1", "attributes": { "go_molecular_function": [ "['protein kinase binding', 'tubulin binding', 'microtubule binding', 'protein binding', 'microtubule plus-end binding', 'tau protein binding']" ], "pathway_id": [ "kegg_path:hsa04962", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05022", "kegg_path:hsa05132", "R-HSA-1280218", "R-HSA-168256", "R-HSA-199977", "R-HSA-199991", "R-HSA-2132295", "R-HSA-2262752", "R-HSA-3371497", "R-HSA-381038", "R-HSA-381070", "R-HSA-381119", "R-HSA-392499", "R-HSA-446203", "R-HSA-5653656", "R-HSA-597592", "R-HSA-6807878", "R-HSA-6811436", "R-HSA-6811442", "R-HSA-8856688", "R-HSA-8953897", "R-HSA-948021" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q14203", "ensembl_id": "None", "entrez_id": "ENSG00000204843", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.560161" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "529" }, { "type": "SmallVariant", "id": "537" }, { "type": "SmallVariant", "id": "543" }, { "type": "SmallVariant", "id": "548" }, { "type": "SmallVariant", "id": "933" }, { "type": "SmallVariant", "id": "1724" }, { "type": "SmallVariant", "id": "2060" }, { "type": "SmallVariant", "id": "2084" }, { "type": "SmallVariant", "id": "3433" }, { "type": "SmallVariant", "id": "3445" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DCTN1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DCTN1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "175" }, { "type": "GeneCombination", "id": "181" }, { "type": "GeneCombination", "id": "184" }, { "type": "GeneCombination", "id": "185" }, { "type": "GeneCombination", "id": "187" }, { "type": "GeneCombination", "id": "295" }, { "type": "GeneCombination", "id": "567" }, { "type": "GeneCombination", "id": "710" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "1151" }, { "type": "GeneCombination", "id": "1157" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DCTN1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DCTN1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DCTN1/?format=api" } }, { "type": "Gene", "id": "SETX", "attributes": { "go_molecular_function": [ "['DNA binding', 'hydrolase activity', 'protein binding', 'RNA binding', 'DNA helicase activity', 'transcription termination site sequence-specific DNA binding', 'identical protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa05014" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q7Z333", "ensembl_id": "None", "entrez_id": "ENSG00000107290", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.749548" }, "relationships": { "variant_set": { "meta": { "count": 23 }, "data": [ { "type": "SmallVariant", "id": "528" }, { "type": "SmallVariant", "id": "538" }, { "type": "SmallVariant", "id": "544" }, { "type": "SmallVariant", "id": "546" }, { "type": "SmallVariant", "id": "547" }, { "type": "SmallVariant", "id": "921" }, { "type": "SmallVariant", "id": "929" }, { "type": "SmallVariant", "id": "1381" }, { "type": "SmallVariant", "id": "1425" }, { "type": "SmallVariant", "id": "1431" }, { "type": "SmallVariant", "id": "1439" }, { "type": "SmallVariant", "id": "1726" }, { "type": "SmallVariant", "id": "1727" }, { "type": "SmallVariant", "id": "2041" }, { "type": "SmallVariant", "id": "2044" }, { "type": "SmallVariant", "id": "2054" }, { "type": "SmallVariant", "id": "2099" }, { "type": "SmallVariant", "id": "2100" }, { "type": "SmallVariant", "id": "2637" }, { "type": "SmallVariant", "id": "3435" }, { "type": "SmallVariant", "id": "3443" }, { "type": "SmallVariant", "id": "3608" }, { "type": "SmallVariant", "id": "3609" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SETX/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SETX/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "174" }, { "type": "GeneCombination", "id": "177" }, { "type": "GeneCombination", "id": "180" }, { "type": "GeneCombination", "id": "181" }, { "type": "GeneCombination", "id": "185" }, { "type": "GeneCombination", "id": "186" }, { "type": "GeneCombination", "id": "187" }, { "type": "GeneCombination", "id": "290" }, { "type": "GeneCombination", "id": "452" }, { "type": "GeneCombination", "id": "454" }, { "type": "GeneCombination", "id": "456" }, { "type": "GeneCombination", "id": "458" }, { "type": "GeneCombination", "id": "568" }, { "type": "GeneCombination", "id": "703" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "879" }, { "type": "GeneCombination", "id": "1156" }, { "type": "GeneCombination", "id": "1213" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SETX/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SETX/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SETX/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }