Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/441/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AKAP9", "attributes": { "go_molecular_function": [ "protein binding", "DNA binding", "signaling receptor binding", "transmembrane transporter binding", "molecular adaptor activity", "protein kinase A regulatory subunit binding", "potassium channel regulator activity" ], "pathway_id": [ "R-HSA-6802957", "R-HSA-2565942", "R-HSA-397014", "R-HSA-453274", "R-HSA-5663202", "R-HSA-1852241", "R-HSA-1643685", "R-HSA-380320", "R-HSA-5617833", "R-HSA-68886", "R-HSA-380259", "R-HSA-5576893", "R-HSA-6802952", "R-HSA-8854518", "R-HSA-380287", "R-HSA-5620912", "R-HSA-68877", "R-HSA-5576890", "R-HSA-69278", "R-HSA-380270", "R-HSA-5576891", "R-HSA-1640170", "R-HSA-380284", "R-HSA-69275" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q99996", "ensembl_id": "ENSG00000127914", "entrez_id": "10142", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.687932" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1405" }, { "type": "SmallVariant", "id": "2334" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKAP9/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKAP9/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "441" }, { "type": "GeneCombination", "id": "786" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKAP9/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKAP9/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AKAP9/?format=api" } }, { "type": "Gene", "id": "CACNA1C", "attributes": { "go_molecular_function": [ "voltage-gated ion channel activity", "voltage-gated calcium channel activity", "high voltage-gated calcium channel activity", "ion channel activity", "calcium channel activity", "calmodulin binding" ], "pathway_id": [ "R-HSA-400042", "kegg_path:hsa04934", "kegg_path:hsa04270", "kegg_path:hsa04713", "kegg_path:hsa04261", "kegg_path:hsa04022", "R-HSA-422356", "kegg_path:hsa05410", "kegg_path:hsa04924", "kegg_path:hsa04260", "kegg_path:hsa04723", "kegg_path:hsa05412", "kegg_path:hsa04024", "kegg_path:hsa04925", "kegg_path:hsa05022", "kegg_path:hsa04727", "kegg_path:hsa04724", "kegg_path:hsa05010", "kegg_path:hsa05020", "R-HSA-5576893", "kegg_path:hsa04010", "kegg_path:hsa04726", "kegg_path:hsa04742", "kegg_path:hsa04020", "kegg_path:hsa05031", "kegg_path:hsa04912", "kegg_path:hsa04929", "R-HSA-1266738", "R-HSA-5576891", "kegg_path:hsa04725", "kegg_path:hsa04728", "R-HSA-375165", "kegg_path:hsa04911", "kegg_path:hsa05031", "kegg_path:hsa04912", "kegg_path:hsa04929", "R-HSA-5576892", "kegg_path:hsa04911", "kegg_path:hsa04725", "kegg_path:hsa04728", "R-HSA-163685", "kegg_path:hsa04727", "kegg_path:hsa04024", "kegg_path:hsa04925", "kegg_path:hsa05022", "kegg_path:hsa05412", "R-HSA-1430728", "kegg_path:hsa05010", "kegg_path:hsa05020", "kegg_path:hsa04724", "kegg_path:hsa04742", "kegg_path:hsa04726", "R-HSA-397014", "kegg_path:hsa04010", "kegg_path:hsa04020", "kegg_path:hsa04720", "kegg_path:hsa05410", "kegg_path:hsa04924", "kegg_path:hsa05414", "kegg_path:hsa04723", "kegg_path:hsa04260", "R-HSA-419037", "kegg_path:hsa04934", "kegg_path:hsa04930", "kegg_path:hsa04935", "kegg_path:hsa04921", "kegg_path:hsa04270", "kegg_path:hsa04713", "kegg_path:hsa04022", "kegg_path:hsa04261", "R-HSA-422475", "R-HSA-9675108", "kegg_path:hsa04927", "kegg_path:hsa04935", "kegg_path:hsa04930", "kegg_path:hsa04921", "kegg_path:hsa04927", "kegg_path:hsa04720", "kegg_path:hsa05414" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13936", "ensembl_id": "ENSG00000151067", "entrez_id": "775", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.946011" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "1024" }, { "type": "SmallVariant", "id": "1030" }, { "type": "SmallVariant", "id": "1032" }, { "type": "SmallVariant", "id": "1034" }, { "type": "SmallVariant", "id": "1041" }, { "type": "SmallVariant", "id": "1048" }, { "type": "SmallVariant", "id": "1050" }, { "type": "SmallVariant", "id": "1394" }, { "type": "SmallVariant", "id": "1403" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA1C/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CACNA1C/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "327" }, { "type": "GeneCombination", "id": "331" }, { "type": "GeneCombination", "id": "332" }, { "type": "GeneCombination", "id": "333" }, { "type": "GeneCombination", "id": "335" }, { "type": "GeneCombination", "id": "338" }, { "type": "GeneCombination", "id": "340" }, { "type": "GeneCombination", "id": "341" }, { "type": "GeneCombination", "id": "342" }, { "type": "GeneCombination", "id": "439" }, { "type": "GeneCombination", "id": "441" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA1C/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CACNA1C/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA1C/?format=api" } }, { "type": "Gene", "id": "DSC2", "attributes": { "go_molecular_function": [ "['cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication', 'calcium ion binding', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa05412", "R-HSA-1266738", "R-HSA-6805567", "R-HSA-6809371" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q02487", "ensembl_id": "None", "entrez_id": "ENSG00000134755", "chromosome_number": "18", "lastmodified": "2021-10-18T11:00:44.944986" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "523" }, { "type": "SmallVariant", "id": "1404" }, { "type": "SmallVariant", "id": "3766" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DSC2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DSC2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "172" }, { "type": "GeneCombination", "id": "441" }, { "type": "GeneCombination", "id": "1275" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DSC2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DSC2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DSC2/?format=api" } }, { "type": "Gene", "id": "OBSCN", "attributes": { "go_molecular_function": [ "phosphatidylinositol-3-phosphate binding", "protein binding", "phosphatidylinositol-3,4-bisphosphate binding", "protein serine/threonine kinase activity", "phosphatidylinositol-3,4,5-trisphosphate binding", "cell adhesion molecule binding", "protein serine/threonine/tyrosine kinase activity", "phosphatidylinositol-5-phosphate binding", "ankyrin binding", "metal ion binding", "guanyl-nucleotide exchange factor activity", "phosphatidylinositol-4-phosphate binding", "ATP binding", "structural constituent of muscle", "calmodulin binding", "titin binding", "protein serine kinase activity", "phosphatidylinositol-4,5-bisphosphate binding" ], "pathway_id": [ "R-HSA-416482", "R-HSA-194840", "R-HSA-194315", "R-HSA-73887", "R-HSA-388396", "R-HSA-193648", "R-HSA-162582", "R-HSA-372790", "R-HSA-193704", "R-HSA-204998" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "A6NGQ3", "ensembl_id": "ENSG00000154358", "entrez_id": "84033", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.673864" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1402" }, { "type": "SmallVariant", "id": "2116" }, { "type": "SmallVariant", "id": "2117" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/OBSCN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/OBSCN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "441" }, { "type": "GeneCombination", "id": "729" }, { "type": "GeneCombination", "id": "730" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/OBSCN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/OBSCN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/OBSCN/?format=api" } }, { "type": "Gene", "id": "RBM20", "attributes": { "go_molecular_function": [ "mRNA binding", "protein binding", "RNA binding", "nucleic acid binding", "zinc ion binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q5T481", "ensembl_id": "ENSG00000203867", "entrez_id": "282996", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.352105" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "459" }, { "type": "SmallVariant", "id": "1406" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RBM20/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RBM20/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "152" }, { "type": "GeneCombination", "id": "441" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RBM20/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RBM20/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RBM20/?format=api" } }, { "type": "Gene", "id": "RYR2", "attributes": { "go_molecular_function": [ "['protein kinase A regulatory subunit binding', 'enzyme binding', 'calcium-induced calcium release activity', 'calcium channel activity', 'protein self-association', 'transmembrane transporter binding', 'calcium ion binding', 'ryanodine-sensitive calcium-release channel activity', 'calcium-release channel activity', 'calmodulin binding', 'protein binding', 'protein kinase A catalytic subunit binding', 'identical protein binding', 'suramin binding']" ], "pathway_id": [ "kegg_path:hsa04020", "kegg_path:hsa04024", "kegg_path:hsa04260", "kegg_path:hsa04261", "kegg_path:hsa04371", "kegg_path:hsa04713", "kegg_path:hsa04911", "kegg_path:hsa04921", "kegg_path:hsa04972", "kegg_path:hsa05020", "kegg_path:hsa05022", "kegg_path:hsa05410", "kegg_path:hsa05412", "kegg_path:hsa05414", "R-HSA-2672351", "R-HSA-382551", "R-HSA-397014", "R-HSA-5576891", "R-HSA-5578775", "R-HSA-983712" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q92736", "ensembl_id": "None", "entrez_id": "ENSG00000198626", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.864866" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1401" }, { "type": "SmallVariant", "id": "2125" }, { "type": "SmallVariant", "id": "3074" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RYR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RYR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "441" }, { "type": "GeneCombination", "id": "732" }, { "type": "GeneCombination", "id": "1031" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RYR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RYR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RYR2/?format=api" } }, { "type": "Gene", "id": "TECRL", "attributes": { "go_molecular_function": [ "oxidoreductase activity, acting on the CH-CH group of donors", "oxidoreductase activity" ], "pathway_id": [ "R-HSA-1430728", "R-HSA-556833", "R-HSA-75876", "R-HSA-75105", "R-HSA-8978868" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q5HYJ1", "ensembl_id": "ENSG00000205678", "entrez_id": "253017", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.480508" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1407" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TECRL/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TECRL/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "441" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TECRL/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TECRL/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TECRL/?format=api" } }, { "type": "Gene", "id": "VCL", "attributes": { "go_molecular_function": [ "protein binding", "structural molecule activity" ], "pathway_id": [ "R-HSA-6802948", "R-HSA-76005", "R-HSA-5683057", "R-HSA-6798695", "R-HSA-9656223", "kegg_path:hsa05131", "kegg_path:hsa04670", "R-HSA-5663202", "R-HSA-5673001", "R-HSA-6802955", "R-HSA-162582", "R-HSA-9649948", "R-HSA-5684996", "R-HSA-6802952", "R-HSA-168256", "R-HSA-6802946", "R-HSA-76002", "kegg_path:hsa05100", "R-HSA-114608", "kegg_path:hsa04520", "kegg_path:hsa05146", "R-HSA-5674135", "R-HSA-6802957", "R-HSA-109582", "R-HSA-397014", "R-HSA-1643685", "R-HSA-445355", "kegg_path:hsa04810", "R-HSA-168249", "R-HSA-6802949", "kegg_path:hsa04510" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P18206", "ensembl_id": "ENSG00000035403", "entrez_id": "7414", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.421369" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1408" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/VCL/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/VCL/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "441" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/VCL/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/VCL/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/VCL/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 8 } }