Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1075/genes/?format=api
{ "data": [ { "type": "Gene", "id": "HSD17B3", "attributes": { "go_molecular_function": [ "['17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'oxidoreductase activity', 'testosterone dehydrogenase [NAD(P)] activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa01100", "R-HSA-1430728", "R-HSA-193048", "R-HSA-196071", "R-HSA-556833", "R-HSA-75105", "R-HSA-75876", "R-HSA-8957322", "R-HSA-8978868", "kegg_path:hsa00140", "kegg_path:hsa01100" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P37058", "ensembl_id": "None", "entrez_id": "ENSG00000130948", "chromosome_number": "9", "lastmodified": "2023-05-16T12:02:33.563033" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "3185" }, { "type": "SmallVariant", "id": "3215" }, { "type": "SmallVariant", "id": "3237" }, { "type": "SmallVariant", "id": "3283" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "1064" }, { "type": "GeneCombination", "id": "1066" }, { "type": "GeneCombination", "id": "1075" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1106" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B3/?format=api" } }, { "type": "Gene", "id": "ZFPM2", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'transcription coactivator activity', 'DNA binding', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'protein binding', 'transcription corepressor activity']" ], "pathway_id": [ "kegg_path:hsa05206", "R-HSA-109582", "R-HSA-1266738", "R-HSA-9690406", "R-HSA-983231" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8WW38", "ensembl_id": "None", "entrez_id": "ENSG00000169946", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.324439" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "862" }, { "type": "SmallVariant", "id": "1213" }, { "type": "SmallVariant", "id": "1446" }, { "type": "SmallVariant", "id": "3216" }, { "type": "SmallVariant", "id": "3250" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZFPM2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZFPM2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "267" }, { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "689" }, { "type": "GeneCombination", "id": "1075" }, { "type": "GeneCombination", "id": "1090" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZFPM2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZFPM2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZFPM2/?format=api" } }, { "type": "Gene", "id": "ZNRF3", "attributes": { "go_molecular_function": [ "['ubiquitin-protein transferase activity', 'frizzled binding', 'protein binding', 'metal ion binding', 'ubiquitin protein ligase activity']" ], "pathway_id": [ "kegg_path:hsa04310", "R-HSA-162582", "R-HSA-195721", "R-HSA-201681", "R-HSA-4641263" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9ULT6", "ensembl_id": "None", "entrez_id": "ENSG00000183579", "chromosome_number": "22", "lastmodified": "2021-10-18T11:00:44.653587" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "1541" }, { "type": "SmallVariant", "id": "1555" }, { "type": "SmallVariant", "id": "1642" }, { "type": "SmallVariant", "id": "1673" }, { "type": "SmallVariant", "id": "3203" }, { "type": "SmallVariant", "id": "3235" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZNRF3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZNRF3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "494" }, { "type": "GeneCombination", "id": "500" }, { "type": "GeneCombination", "id": "533" }, { "type": "GeneCombination", "id": "545" }, { "type": "GeneCombination", "id": "1070" }, { "type": "GeneCombination", "id": "1075" }, { "type": "GeneCombination", "id": "1083" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZNRF3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZNRF3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZNRF3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }