Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1065/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FGFR2", "attributes": { "go_molecular_function": [ "['protein tyrosine kinase activity', 'ATP binding', 'fibroblast growth factor binding', 'protein binding', 'heparin binding', 'protein homodimerization activity', 'protein serine/threonine/tyrosine kinase activity', 'fibroblast growth factor-activated receptor activity', 'transmembrane receptor protein tyrosine kinase activity']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04144", "kegg_path:hsa04151", "kegg_path:hsa04550", "kegg_path:hsa04810", "kegg_path:hsa05200", "kegg_path:hsa05215", "kegg_path:hsa05226", "kegg_path:hsa05230", "R-HSA-1226099", "R-HSA-1643685", "R-HSA-1839126", "R-HSA-2023837", "R-HSA-2033519", "R-HSA-5655253", "R-HSA-5663202", "R-HSA-8851708", "R-HSA-8853333" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P21802", "ensembl_id": "None", "entrez_id": "ENSG00000066468", "chromosome_number": "10", "lastmodified": "2023-05-16T12:02:33.529095" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3171" }, { "type": "SmallVariant", "id": "3190" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGFR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1059" }, { "type": "GeneCombination", "id": "1065" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGFR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR2/?format=api" } }, { "type": "Gene", "id": "GHRHR", "attributes": { "go_molecular_function": [ "['peptide hormone binding', 'growth hormone-releasing hormone receptor activity', 'G protein-coupled receptor activity', 'G protein-coupled peptide receptor activity', 'protein binding', 'growth factor binding']" ], "pathway_id": [ "kegg_path:hsa04080", "kegg_path:hsa04935", "kegg_path:hsa04080", "kegg_path:hsa04935", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373080", "R-HSA-388396", "R-HSA-418555", "R-HSA-420092", "R-HSA-500792", "R-HSA-5663205", "R-HSA-9658195", "R-HSA-9660821", "R-HSA-9662851", "R-HSA-9664433" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q02643", "ensembl_id": "None", "entrez_id": "ENSG00000106128", "chromosome_number": "7", "lastmodified": "2023-05-16T12:02:33.566892" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3187" }, { "type": "SmallVariant", "id": "3298" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHRHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHRHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1065" }, { "type": "GeneCombination", "id": "1109" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHRHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHRHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GHRHR/?format=api" } }, { "type": "Gene", "id": "MYRF", "attributes": { "go_molecular_function": [ "['DNA-binding transcription factor activity, RNA polymerase II-specific', 'sequence-specific DNA binding', 'DNA-binding transcription factor activity', 'peptidase activity']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9Y2G1", "ensembl_id": "None", "entrez_id": "ENSG00000124920", "chromosome_number": "11", "lastmodified": "2023-05-16T12:02:33.516815" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3166" }, { "type": "SmallVariant", "id": "3188" }, { "type": "SmallVariant", "id": "3310" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYRF/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYRF/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "1057" }, { "type": "GeneCombination", "id": "1060" }, { "type": "GeneCombination", "id": "1065" }, { "type": "GeneCombination", "id": "1080" }, { "type": "GeneCombination", "id": "1113" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYRF/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYRF/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MYRF/?format=api" } }, { "type": "Gene", "id": "PROP1", "attributes": { "go_molecular_function": [ "['chromatin binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'beta-catenin binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'sequence-specific double-stranded DNA binding', 'protein C-terminus binding', 'protein binding', 'DNA-binding transcription repressor activity, RNA polymerase II-specific']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O75360", "ensembl_id": "None", "entrez_id": "ENSG00000175325", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.328145" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "2976" }, { "type": "SmallVariant", "id": "40" }, { "type": "SmallVariant", "id": "1307" }, { "type": "SmallVariant", "id": "2906" }, { "type": "SmallVariant", "id": "3189" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROP1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROP1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "16" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "963" }, { "type": "GeneCombination", "id": "964" }, { "type": "GeneCombination", "id": "992" }, { "type": "GeneCombination", "id": "1065" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROP1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROP1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PROP1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }