Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/225/genes/?format=api
{ "data": [ { "type": "Gene", "id": "MYO18B", "attributes": { "go_molecular_function": [ "ATP binding", "cytoskeletal motor activity", "actin binding", "nucleotide binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8IUG5", "ensembl_id": "ENSG00000133454", "entrez_id": "84700", "chromosome_number": "22", "lastmodified": "2021-10-18T11:00:44.440172" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "702" }, { "type": "SmallVariant", "id": "714" }, { "type": "SmallVariant", "id": "716" }, { "type": "SmallVariant", "id": "1734" }, { "type": "SmallVariant", "id": "1735" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYO18B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYO18B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "225" }, { "type": "GeneCombination", "id": "229" }, { "type": "GeneCombination", "id": "230" }, { "type": "GeneCombination", "id": "571" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYO18B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYO18B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MYO18B/?format=api" } }, { "type": "Gene", "id": "SUFU", "attributes": { "go_molecular_function": [ "transcription corepressor activity" ], "pathway_id": [ "R-HSA-5358351", "R-HSA-162582", "R-HSA-5610787", "kegg_path:hsa05200", "kegg_path:hsa05217", "R-HSA-5610780", "R-HSA-5632684", "kegg_path:hsa04340", "R-HSA-5610785", "R-HSA-5610783" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9UMX1", "ensembl_id": "ENSG00000107882", "entrez_id": "51684", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.812751" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "700" }, { "type": "SmallVariant", "id": "703" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SUFU/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SUFU/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "224" }, { "type": "GeneCombination", "id": "225" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SUFU/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SUFU/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SUFU/?format=api" } }, { "type": "Gene", "id": "WNT7A", "attributes": { "go_molecular_function": [ "signaling receptor binding", "cytokine activity", "protein binding", "frizzled binding" ], "pathway_id": [ "kegg_path:hsa05010", "kegg_path:hsa04390", "kegg_path:hsa05224", "kegg_path:hsa04150", "kegg_path:hsa05205", "kegg_path:hsa05200", "kegg_path:hsa05225", "kegg_path:hsa04916", "kegg_path:hsa05022", "kegg_path:hsa05217", "R-HSA-3238698", "kegg_path:hsa04310", "R-HSA-195721", "R-HSA-373080", "kegg_path:hsa05226", "R-HSA-162582", "R-HSA-372790", "R-HSA-500792", "kegg_path:hsa04550", "kegg_path:hsa05165", "kegg_path:hsa04934" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O00755", "ensembl_id": "ENSG00000154764", "entrez_id": "7476", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.770302" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "704" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/WNT7A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/WNT7A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "225" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/WNT7A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/WNT7A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/WNT7A/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }