Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1127/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ENOSF1", "attributes": { "go_molecular_function": [ "['hydro-lyase activity', 'L-fuconate dehydratase activity', 'isomerase activity', 'magnesium ion binding']" ], "pathway_id": [ "kegg_path:hsa00051", "kegg_path:hsa01100" ], "essential_gene": null, "status": "CU", "uniprot_acc": "A0A3F2YNX7", "ensembl_id": "None", "entrez_id": "ENSG00000132199", "chromosome_number": "18", "lastmodified": "2023-05-16T12:02:33.717643" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "3339" }, { "type": "SmallVariant", "id": "3341" }, { "type": "SmallVariant", "id": "3342" }, { "type": "SmallVariant", "id": "3345" }, { "type": "SmallVariant", "id": "3349" }, { "type": "SmallVariant", "id": "3351" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ENOSF1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ENOSF1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1126" }, { "type": "GeneCombination", "id": "1127" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ENOSF1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ENOSF1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ENOSF1/?format=api" } }, { "type": "Gene", "id": "TYMS", "attributes": { "go_molecular_function": [ "['thymidylate synthase activity', 'sequence-specific mRNA binding', 'translation repressor activity, mRNA regulatory element binding', 'folic acid binding', 'protein homodimerization activity']" ], "pathway_id": [ "kegg_path:hsa00240", "kegg_path:hsa00670", "kegg_path:hsa01100", "kegg_path:hsa01523", "R-HSA-1430728", "R-HSA-15869", "R-HSA-1640170", "R-HSA-453279", "R-HSA-499943", "R-HSA-69205", "R-HSA-69206", "R-HSA-69278", "kegg_path:hsa00240", "kegg_path:hsa00670", "kegg_path:hsa01100", "kegg_path:hsa01523" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P04818", "ensembl_id": "None", "entrez_id": "ENSG00000176890", "chromosome_number": "18", "lastmodified": "2023-05-16T12:02:33.713534" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "CopyNumberVariant", "id": "3336" }, { "type": "SmallVariant", "id": "3337" }, { "type": "SmallVariant", "id": "3338" }, { "type": "SmallVariant", "id": "3340" }, { "type": "SmallVariant", "id": "3343" }, { "type": "SmallVariant", "id": "3344" }, { "type": "SmallVariant", "id": "3346" }, { "type": "SmallVariant", "id": "3348" }, { "type": "SmallVariant", "id": "3350" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TYMS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TYMS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1126" }, { "type": "GeneCombination", "id": "1127" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TYMS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TYMS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TYMS/?format=api" } }, { "type": "Gene", "id": "TYMSOS", "attributes": { "go_molecular_function": [ "['protein binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000176912", "chromosome_number": "18", "lastmodified": "2023-05-16T12:02:33.721905" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3347" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TYMSOS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TYMSOS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1127" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TYMSOS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TYMSOS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TYMSOS/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }