Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/488/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CELSR2", "attributes": { "go_molecular_function": [ "G protein-coupled receptor activity", "transmembrane signaling receptor activity", "calcium ion binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9HCU4", "ensembl_id": "ENSG00000143126", "entrez_id": "1952", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.972153" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "1519" }, { "type": "SmallVariant", "id": "1536" }, { "type": "SmallVariant", "id": "1617" }, { "type": "SmallVariant", "id": "1623" }, { "type": "SmallVariant", "id": "1650" }, { "type": "SmallVariant", "id": "1665" }, { "type": "SmallVariant", "id": "1691" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "488" }, { "type": "GeneCombination", "id": "490" }, { "type": "GeneCombination", "id": "493" }, { "type": "GeneCombination", "id": "509" }, { "type": "GeneCombination", "id": "520" }, { "type": "GeneCombination", "id": "523" }, { "type": "GeneCombination", "id": "525" }, { "type": "GeneCombination", "id": "535" }, { "type": "GeneCombination", "id": "536" }, { "type": "GeneCombination", "id": "542" }, { "type": "GeneCombination", "id": "551" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR2/?format=api" } }, { "type": "Gene", "id": "DLC1", "attributes": { "go_molecular_function": [ "GTPase activator activity", "lipid binding", "protein binding" ], "pathway_id": [ "R-HSA-194315", "R-HSA-194840", "R-HSA-162582" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q96QB1", "ensembl_id": "ENSG00000164741", "entrez_id": "10395", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.699643" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1523" }, { "type": "SmallVariant", "id": "1656" }, { "type": "SmallVariant", "id": "1676" }, { "type": "SmallVariant", "id": "1690" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DLC1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DLC1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "488" }, { "type": "GeneCombination", "id": "537" }, { "type": "GeneCombination", "id": "546" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DLC1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DLC1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DLC1/?format=api" } }, { "type": "Gene", "id": "FZD6", "attributes": { "go_molecular_function": [ "Wnt-protein binding", "G protein-coupled receptor activity", "protein binding", "Wnt-activated receptor activity" ], "pathway_id": [ "R-HSA-162582", "R-HSA-373080", "R-HSA-5663202", "kegg_path:hsa05205", "kegg_path:hsa05022", "kegg_path:hsa05200", "kegg_path:hsa05022", "kegg_path:hsa05205", "R-HSA-5340588", "kegg_path:hsa05200", "kegg_path:hsa04934", "kegg_path:hsa04310", "kegg_path:hsa04550", "kegg_path:hsa05165", "kegg_path:hsa04390", "kegg_path:hsa05010", "kegg_path:hsa05226", "R-HSA-201681", "kegg_path:hsa04150", "kegg_path:hsa05217", "R-HSA-1643685", "kegg_path:hsa05224", "kegg_path:hsa05225", "kegg_path:hsa05217", "kegg_path:hsa04150", "kegg_path:hsa05225", "kegg_path:hsa05224", "kegg_path:hsa04390", "R-HSA-4086400", "R-HSA-4791275", "kegg_path:hsa05226", "kegg_path:hsa05010", "kegg_path:hsa04934", "R-HSA-500792", "R-HSA-372790", "kegg_path:hsa04550", "kegg_path:hsa05165", "kegg_path:hsa04310", "R-HSA-195721", "kegg_path:hsa04916", "kegg_path:hsa04916", "R-HSA-4641263", "R-HSA-3858494", "R-HSA-4086398" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O60353", "ensembl_id": "ENSG00000164930", "entrez_id": "8323", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.861195" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1522" }, { "type": "SmallVariant", "id": "1560" }, { "type": "SmallVariant", "id": "1578" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FZD6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FZD6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "488" }, { "type": "GeneCombination", "id": "501" }, { "type": "GeneCombination", "id": "507" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FZD6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FZD6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FZD6/?format=api" } }, { "type": "Gene", "id": "MTHFD1", "attributes": { "go_molecular_function": [ "formate-tetrahydrofolate ligase activity", "protein binding", "methylenetetrahydrofolate dehydrogenase (NADP+) activity", "methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity", "methenyltetrahydrofolate cyclohydrolase activity" ], "pathway_id": [ "kegg_path:hsa00670", "kegg_path:hsa01240", "kegg_path:hsa01100", "R-HSA-1430728", "kegg_path:hsa00670", "kegg_path:hsa01100", "kegg_path:hsa01240", "R-HSA-196757", "R-HSA-196854", "R-HSA-196849" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P11586", "ensembl_id": "ENSG00000100714", "entrez_id": "4522", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.454249" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1520" }, { "type": "SmallVariant", "id": "1577" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTHFD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "488" }, { "type": "GeneCombination", "id": "507" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTHFD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFD1/?format=api" } }, { "type": "Gene", "id": "SHROOM3", "attributes": { "go_molecular_function": [ "actin filament binding", "actin binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8TF72", "ensembl_id": "ENSG00000138771", "entrez_id": "57619", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.265166" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1521" }, { "type": "SmallVariant", "id": "1613" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHROOM3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "488" }, { "type": "GeneCombination", "id": "518" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHROOM3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }