Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/240/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CDH23", "attributes": { "go_molecular_function": [ "['calcium ion binding', 'protein binding', 'cadherin binding']" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9H251", "ensembl_id": "None", "entrez_id": "ENSG00000107736", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.400908" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "208" }, { "type": "SmallVariant", "id": "217" }, { "type": "SmallVariant", "id": "223" }, { "type": "SmallVariant", "id": "508" }, { "type": "SmallVariant", "id": "510" }, { "type": "SmallVariant", "id": "511" }, { "type": "SmallVariant", "id": "518" }, { "type": "SmallVariant", "id": "520" }, { "type": "SmallVariant", "id": "521" }, { "type": "SmallVariant", "id": "658" }, { "type": "SmallVariant", "id": "719" }, { "type": "SmallVariant", "id": "746" }, { "type": "SmallVariant", "id": "753" }, { "type": "SmallVariant", "id": "758" }, { "type": "SmallVariant", "id": "1055" }, { "type": "SmallVariant", "id": "1284" }, { "type": "SmallVariant", "id": "2234" }, { "type": "SmallVariant", "id": "2240" }, { "type": "SmallVariant", "id": "2390" }, { "type": "SmallVariant", "id": "2870" }, { "type": "SmallVariant", "id": "3543" }, { "type": "SmallVariant", "id": "3551" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CDH23/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CDH23/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 17 }, "data": [ { "type": "GeneCombination", "id": "81" }, { "type": "GeneCombination", "id": "75" }, { "type": "GeneCombination", "id": "79" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "171" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "345" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "814" }, { "type": "GeneCombination", "id": "813" }, { "type": "GeneCombination", "id": "812" }, { "type": "GeneCombination", "id": "810" }, { "type": "GeneCombination", "id": "1193" }, { "type": "GeneCombination", "id": "1195" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CDH23/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CDH23/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CDH23/?format=api" } }, { "type": "Gene", "id": "EVC", "attributes": { "go_molecular_function": [], "pathway_id": [ "kegg_path:hsa04340", "R-HSA-162582", "R-HSA-5358351", "R-HSA-5632684", "R-HSA-5635838" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000072840", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.537890" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "764" }, { "type": "SmallVariant", "id": "765" }, { "type": "SmallVariant", "id": "1270" }, { "type": "SmallVariant", "id": "1277" }, { "type": "SmallVariant", "id": "1311" }, { "type": "SmallVariant", "id": "2635" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EVC/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EVC/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "878" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EVC/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EVC/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/EVC/?format=api" } }, { "type": "Gene", "id": "FLNA", "attributes": { "go_molecular_function": [ "['RNA binding', 'Fc-gamma receptor I complex binding', 'small GTPase binding', 'actin filament binding', 'protein kinase C binding', 'transmembrane transporter binding', 'cadherin binding', 'potassium channel regulator activity', 'kinase binding', 'G protein-coupled receptor binding', 'protein binding', 'GTPase binding', 'protein homodimerization activity', 'DNA-binding transcription factor binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "R-HSA-109582", "R-HSA-114608", "R-HSA-1169410", "R-HSA-1280215", "R-HSA-1500931", "R-HSA-162582", "R-HSA-168256", "R-HSA-194315", "R-HSA-195258", "R-HSA-430116", "R-HSA-446353", "R-HSA-446728", "R-HSA-5627123", "R-HSA-76002", "R-HSA-76005", "R-HSA-8983711", "R-HSA-913531", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "R-HSA-109582", "R-HSA-114608", "R-HSA-1169410", "R-HSA-1280215", "R-HSA-1500931", "R-HSA-162582", "R-HSA-168256", "R-HSA-194315", "R-HSA-195258", "R-HSA-430116", "R-HSA-446353", "R-HSA-446728", "R-HSA-5627123", "R-HSA-76002", "R-HSA-76005", "R-HSA-8983711", "R-HSA-913531", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205", "kegg_path:hsa04010", "kegg_path:hsa04510", "kegg_path:hsa05132", "kegg_path:hsa05205" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P21333", "ensembl_id": "None", "entrez_id": "ENSG00000196924", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.390873" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "767" }, { "type": "SmallVariant", "id": "1298" }, { "type": "SmallVariant", "id": "3177" }, { "type": "SmallVariant", "id": "3241" }, { "type": "SmallVariant", "id": "3277" }, { "type": "SmallVariant", "id": "3314" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLNA/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLNA/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1086" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLNA/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLNA/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FLNA/?format=api" } }, { "type": "Gene", "id": "FRAS1", "attributes": { "go_molecular_function": [ "extracellular matrix structural constituent", "metal ion binding" ], "pathway_id": [ "kegg_path:hsa04512" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q86XX4", "ensembl_id": "ENSG00000138759", "entrez_id": "80144", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.949161" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "709" }, { "type": "SmallVariant", "id": "740" }, { "type": "SmallVariant", "id": "750" }, { "type": "SmallVariant", "id": "751" }, { "type": "SmallVariant", "id": "756" }, { "type": "SmallVariant", "id": "766" }, { "type": "SmallVariant", "id": "1299" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FRAS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FRAS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "227" }, { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FRAS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FRAS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FRAS1/?format=api" } }, { "type": "Gene", "id": "MAML2", "attributes": { "go_molecular_function": [ "transcription coactivator activity" ], "pathway_id": [ "kegg_path:hsa04658", "R-HSA-2197563", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-212436", "R-HSA-9013694", "R-HSA-2122947", "R-HSA-9013695", "R-HSA-1980145", "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "R-HSA-9013508", "kegg_path:hsa04330", "R-HSA-8878159", "R-HSA-162582", "R-HSA-1980143", "R-HSA-1912408", "R-HSA-210744", "R-HSA-2644603", "R-HSA-2894858", "R-HSA-186712", "R-HSA-73857", "R-HSA-157118", "R-HSA-1912422", "R-HSA-2894862", "R-HSA-9012852", "R-HSA-8941856", "R-HSA-1643685", "R-HSA-2644602", "R-HSA-2644606" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q8IZL2", "ensembl_id": "ENSG00000184384", "entrez_id": "84441", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.549023" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "760" }, { "type": "SmallVariant", "id": "1292" }, { "type": "SmallVariant", "id": "1322" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "412" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAML2/?format=api" } }, { "type": "Gene", "id": "MAMLD1", "attributes": { "go_molecular_function": [ "['molecular_function']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695", "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q13495", "ensembl_id": "None", "entrez_id": "ENSG00000013619", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.997839" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "581" }, { "type": "SmallVariant", "id": "717" }, { "type": "SmallVariant", "id": "722" }, { "type": "SmallVariant", "id": "729" }, { "type": "SmallVariant", "id": "733" }, { "type": "SmallVariant", "id": "736" }, { "type": "SmallVariant", "id": "742" }, { "type": "SmallVariant", "id": "745" }, { "type": "SmallVariant", "id": "752" }, { "type": "SmallVariant", "id": "757" }, { "type": "SmallVariant", "id": "1268" }, { "type": "SmallVariant", "id": "1278" }, { "type": "SmallVariant", "id": "1280" }, { "type": "SmallVariant", "id": "1283" }, { "type": "SmallVariant", "id": "1294" }, { "type": "SmallVariant", "id": "1310" }, { "type": "SmallVariant", "id": "1316" }, { "type": "SmallVariant", "id": "3192" }, { "type": "SmallVariant", "id": "3200" }, { "type": "SmallVariant", "id": "3252" }, { "type": "SmallVariant", "id": "3259" }, { "type": "SmallVariant", "id": "3325" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 26 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "237" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "406" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1095" }, { "type": "GeneCombination", "id": "1120" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/?format=api" } }, { "type": "Gene", "id": "MYO7A", "attributes": { "go_molecular_function": [ "['calmodulin binding', 'spectrin binding', 'protein binding', 'protein domain specific binding', 'microfilament motor activity', 'actin filament binding', 'ATP binding']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-2187338", "R-HSA-2453902", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-162582", "R-HSA-2187338", "R-HSA-2453902", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q13402", "ensembl_id": "None", "entrez_id": "ENSG00000137474", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.573189" }, "relationships": { "variant_set": { "meta": { "count": 28 }, "data": [ { "type": "SmallVariant", "id": "509" }, { "type": "SmallVariant", "id": "206" }, { "type": "SmallVariant", "id": "207" }, { "type": "SmallVariant", "id": "211" }, { "type": "SmallVariant", "id": "213" }, { "type": "SmallVariant", "id": "218" }, { "type": "SmallVariant", "id": "221" }, { "type": "SmallVariant", "id": "503" }, { "type": "SmallVariant", "id": "507" }, { "type": "SmallVariant", "id": "720" }, { "type": "SmallVariant", "id": "727" }, { "type": "SmallVariant", "id": "728" }, { "type": "SmallVariant", "id": "737" }, { "type": "SmallVariant", "id": "747" }, { "type": "SmallVariant", "id": "748" }, { "type": "SmallVariant", "id": "759" }, { "type": "SmallVariant", "id": "1323" }, { "type": "SmallVariant", "id": "1324" }, { "type": "SmallVariant", "id": "1975" }, { "type": "SmallVariant", "id": "2233" }, { "type": "SmallVariant", "id": "2235" }, { "type": "SmallVariant", "id": "2237" }, { "type": "SmallVariant", "id": "2239" }, { "type": "SmallVariant", "id": "2241" }, { "type": "SmallVariant", "id": "2243" }, { "type": "SmallVariant", "id": "2245" }, { "type": "SmallVariant", "id": "3704" }, { "type": "SmallVariant", "id": "3712" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYO7A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYO7A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "75" }, { "type": "GeneCombination", "id": "76" }, { "type": "GeneCombination", "id": "77" }, { "type": "GeneCombination", "id": "78" }, { "type": "GeneCombination", "id": "80" }, { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "168" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "758" }, { "type": "GeneCombination", "id": "757" }, { "type": "GeneCombination", "id": "1256" }, { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYO7A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYO7A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MYO7A/?format=api" } }, { "type": "Gene", "id": "NOTCH2", "attributes": { "go_molecular_function": [ "calcium ion binding", "protein binding", "enzyme binding", "NF-kappaB binding", "signaling receptor activity" ], "pathway_id": [ "R-HSA-1912399", "R-HSA-1912408", "R-HSA-162582", "kegg_path:hsa04330", "kegg_path:hsa04919", "kegg_path:hsa05200", "kegg_path:hsa05206", "R-HSA-350054", "R-HSA-74160", "R-HSA-1980145", "kegg_path:hsa05224", "kegg_path:hsa01522", "R-HSA-9013695", "R-HSA-212436", "R-HSA-9013694", "kegg_path:hsa05165", "R-HSA-3906995", "kegg_path:hsa04658", "R-HSA-2197563", "R-HSA-5668914", 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