Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/485/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ALDH1L1", "attributes": { "go_molecular_function": [ "hydroxymethyl-, formyl- and related transferase activity", "protein binding", "catalytic activity", "formyltetrahydrofolate dehydrogenase activity", "aldehyde dehydrogenase (NAD+) activity", "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor", "oxidoreductase activity" ], "pathway_id": [ "R-HSA-196849", "R-HSA-196854", "R-HSA-196757", "kegg_path:hsa00670", "R-HSA-1430728" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O75891", "ensembl_id": "ENSG00000144908", "entrez_id": "10840", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.811028" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1496" }, { "type": "SmallVariant", "id": "1505" }, { "type": "SmallVariant", "id": "1508" }, { "type": "SmallVariant", "id": "1534" }, { "type": "SmallVariant", "id": "1638" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALDH1L1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALDH1L1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "479" }, { "type": "GeneCombination", "id": "483" }, { "type": "GeneCombination", "id": "485" }, { "type": "GeneCombination", "id": "492" }, { "type": "GeneCombination", "id": "530" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALDH1L1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALDH1L1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ALDH1L1/?format=api" } }, { "type": "Gene", "id": "FAT4", "attributes": { "go_molecular_function": [ "protein binding", "calcium ion binding" ], "pathway_id": [ "kegg_path:hsa04392" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q6V0I7", "ensembl_id": "ENSG00000196159", "entrez_id": "79633", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.536840" }, "relationships": { "variant_set": { "meta": { "count": 12 }, "data": [ { "type": "SmallVariant", "id": "1507" }, { "type": "SmallVariant", "id": "1510" }, { "type": "SmallVariant", "id": "1511" }, { "type": "SmallVariant", "id": "1549" }, { "type": "SmallVariant", "id": "1556" }, { "type": "SmallVariant", "id": "1558" }, { "type": "SmallVariant", "id": "1559" }, { "type": "SmallVariant", "id": "1626" }, { "type": "SmallVariant", "id": "1643" }, { "type": "SmallVariant", "id": "1648" }, { "type": "SmallVariant", "id": "1675" }, { "type": "SmallVariant", "id": "1689" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FAT4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FAT4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 9 }, "data": [ { "type": "GeneCombination", "id": "497" }, { "type": "GeneCombination", "id": "484" }, { "type": "GeneCombination", "id": "485" }, { "type": "GeneCombination", "id": "500" }, { "type": "GeneCombination", "id": "501" }, { "type": "GeneCombination", "id": "524" }, { "type": "GeneCombination", "id": "533" }, { "type": "GeneCombination", "id": "535" }, { "type": "GeneCombination", "id": "546" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FAT4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FAT4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FAT4/?format=api" } }, { "type": "Gene", "id": "PCYT1A", "attributes": { "go_molecular_function": [ "transferase activity", "phosphatidylcholine binding", "catalytic activity", "nucleotidyltransferase activity", "choline-phosphate cytidylyltransferase activity" ], "pathway_id": [ "R-HSA-1483257", "kegg_path:hsa05231", "kegg_path:hsa00564", "kegg_path:hsa01100", "R-HSA-556833", "kegg_path:hsa00440", "R-HSA-1483206", "R-HSA-1430728", "R-HSA-1483191" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P49585", "ensembl_id": "ENSG00000161217", "entrez_id": "5130", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.439275" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1509" }, { "type": "SmallVariant", "id": "1621" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PCYT1A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PCYT1A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "485" }, { "type": "GeneCombination", "id": "522" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PCYT1A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PCYT1A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PCYT1A/?format=api" } }, { "type": "Gene", "id": "PTCH1", "attributes": { "go_molecular_function": [ "['cyclin binding', 'patched binding', 'smoothened binding', 'protein-containing complex binding', 'hedgehog family protein binding', 'protein binding', 'heparin binding', 'cholesterol binding', 'hedgehog receptor activity']" ], "pathway_id": [ "kegg_path:hsa04024", "kegg_path:hsa04340", "kegg_path:hsa04360", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05217", "R-HSA-162582", "R-HSA-372790", "R-HSA-373080", "R-HSA-500792", "R-HSA-5358351", "R-HSA-5610787", "R-HSA-5632681", "R-HSA-5632684", "R-HSA-5635838" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13635", "ensembl_id": "None", "entrez_id": "ENSG00000185920", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.300396" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "1471" }, { "type": "SmallVariant", "id": "1502" }, { "type": "SmallVariant", "id": "1512" }, { "type": "SmallVariant", "id": "3316" }, { "type": "SmallVariant", "id": "3317" }, { "type": "SmallVariant", "id": "3318" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PTCH1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PTCH1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "470" }, { "type": "GeneCombination", "id": "481" }, { "type": "GeneCombination", "id": "485" }, { "type": "GeneCombination", "id": "1116" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PTCH1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PTCH1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PTCH1/?format=api" } }, { "type": "Gene", "id": "ZIC3", "attributes": { "go_molecular_function": [ "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "protein binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "sequence-specific double-stranded DNA binding", "DNA-binding transcription factor activity" ], "pathway_id": [ "R-HSA-2892247", "R-HSA-452723", "R-HSA-1266738", "kegg_path:hsa04550" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O60481", "ensembl_id": "ENSG00000156925", "entrez_id": "7547", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.879577" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "304" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZIC3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZIC3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "110" }, { "type": "GeneCombination", "id": "112" }, { "type": "GeneCombination", "id": "485" }, { "type": "GeneCombination", "id": "502" }, { "type": "GeneCombination", "id": "511" }, { "type": "GeneCombination", "id": "548" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZIC3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZIC3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZIC3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }