Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1192/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ARG1", "attributes": { "go_molecular_function": [ "['arginase activity', 'identical protein binding', 'protein binding', 'manganese ion binding']" ], "pathway_id": [ "kegg_path:hsa00220", "kegg_path:hsa00330", "kegg_path:hsa01100", "kegg_path:hsa01230", "kegg_path:hsa05146", "R-HSA-1430728", "R-HSA-168249", "R-HSA-168256", "R-HSA-6798695", "R-HSA-70635", "R-HSA-71291" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P05089", "ensembl_id": "None", "entrez_id": "ENSG00000118520", "chromosome_number": "6", "lastmodified": "2024-02-29T15:02:20.529497" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3538" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ARG1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ARG1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1192" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ARG1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ARG1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ARG1/?format=api" } }, { "type": "Gene", "id": "COL23A1", "attributes": { "go_molecular_function": [ "['extracellular matrix structural constituent conferring tensile strength', 'heparin binding', 'protein binding', 'identical protein binding', 'extracellular matrix structural constituent']" ], "pathway_id": [ "kegg_path:hsa04974", "R-HSA-1442490", "R-HSA-1474228", "R-HSA-1474244", "R-HSA-1474290", "R-HSA-1650814", "R-HSA-216083", "R-HSA-8948216" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q86Y22", "ensembl_id": "None", "entrez_id": "ENSG00000050767", "chromosome_number": "5", "lastmodified": "2024-02-29T15:02:20.525633" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3537" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL23A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL23A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1192" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL23A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL23A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COL23A1/?format=api" } }, { "type": "Gene", "id": "COL4A2", "attributes": { "go_molecular_function": [ "['protein binding', 'extracellular matrix structural constituent conferring tensile strength', 'extracellular matrix structural constituent']" ], "pathway_id": [ "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa04926", "kegg_path:hsa04933", "kegg_path:hsa04974", "kegg_path:hsa05146", "kegg_path:hsa05165", "kegg_path:hsa05200", "kegg_path:hsa05222", "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa04926", "kegg_path:hsa04933", "kegg_path:hsa04974", "kegg_path:hsa05146", "kegg_path:hsa05165", "kegg_path:hsa05200", "kegg_path:hsa05222", "R-HSA-1266738", "R-HSA-1442490", "R-HSA-1474228", "R-HSA-1474244", "R-HSA-1474290", "R-HSA-162582", "R-HSA-1650814", "R-HSA-186797", "R-HSA-2022090", "R-HSA-216083", "R-HSA-2173782", "R-HSA-2214320", "R-HSA-2243919", "R-HSA-3000157", "R-HSA-3000171", "R-HSA-3000178", "R-HSA-3000480", "R-HSA-375165", "R-HSA-419037", "R-HSA-422475", "R-HSA-5653656", "R-HSA-8948216", "R-HSA-9006934", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P08572", "ensembl_id": "None", "entrez_id": "ENSG00000134871", "chromosome_number": "13", "lastmodified": "2024-02-29T15:02:20.522203" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3536" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL4A2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL4A2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1192" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL4A2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL4A2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COL4A2/?format=api" } }, { "type": "Gene", "id": "DUXA", "attributes": { "go_molecular_function": [ "['sequence-specific double-stranded DNA binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "A6NLW8", "ensembl_id": "None", "entrez_id": "ENSG00000258873", "chromosome_number": "19", "lastmodified": "2024-02-29T15:02:20.533114" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3539" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DUXA/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DUXA/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1192" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DUXA/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DUXA/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DUXA/?format=api" } }, { "type": "Gene", "id": "HSPG2", "attributes": { "go_molecular_function": [ "['extracellular matrix structural constituent conferring compression resistance', 'calcium ion binding', 'low-density lipoprotein particle receptor binding', 'protein C-terminus binding', 'protein binding', 'amyloid-beta binding']" ], "pathway_id": [ "kegg_path:hsa04512", "kegg_path:hsa05161", "kegg_path:hsa05205", "R-HSA-1430728", "R-HSA-1474228", "R-HSA-1474244", "R-HSA-162582", "R-HSA-1630316", "R-HSA-1638091", "R-HSA-1643685", "R-HSA-1793185", "R-HSA-196854", "R-HSA-1971475", "R-HSA-2022928", "R-HSA-2024096", "R-HSA-216083", "R-HSA-2187338", "R-HSA-3000157", "R-HSA-3000171", "R-HSA-3000178", "R-HSA-3560782", "R-HSA-3560783", "R-HSA-3560801", "R-HSA-3656237", "R-HSA-3656253", "R-HSA-372790", "R-HSA-3781865", "R-HSA-388396", "R-HSA-392499", "R-HSA-418594", "R-HSA-4420332", "R-HSA-5668914", "R-HSA-6806667", "R-HSA-71387", "R-HSA-975634", "R-HSA-977225" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P98160", "ensembl_id": "None", "entrez_id": "ENSG00000142798", "chromosome_number": "1", "lastmodified": "2022-08-04T14:14:58.093638" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "2224" }, { "type": "SmallVariant", "id": "2225" }, { "type": "SmallVariant", "id": "3527" }, { "type": "SmallVariant", "id": "3535" }, { "type": "SmallVariant", "id": "3553" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSPG2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSPG2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "753" }, { "type": "GeneCombination", "id": "1189" }, { "type": "GeneCombination", "id": "1192" }, { "type": "GeneCombination", "id": "1196" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSPG2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSPG2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HSPG2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }