Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1079/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AKR1C4", "attributes": { "go_molecular_function": [ "['electron transfer activity', 'ketosteroid monooxygenase activity', 'chlordecone reductase activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity', 'androsterone dehydrogenase activity', '17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'steroid dehydrogenase activity', 'D-threo-aldose 1-dehydrogenase activity', 'oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor', '17-beta-hydroxysteroid dehydrogenase (NAD+) activity', 'dihydrotestosterone 17-beta-dehydrogenase activity', 'bile acid transmembrane transporter activity', '5alpha-androstane-3beta,17beta-diol dehydrogenase activity', 'bile acid binding', 'alditol:NADP+ 1-oxidoreductase activity', 'retinal dehydrogenase activity', 'testosterone dehydrogenase (NAD+) activity', 'aldo-keto reductase (NADP) activity', 'androstan-3-alpha,17-beta-diol dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00120", "kegg_path:hsa00140", "kegg_path:hsa01100", "R-HSA-1430728", "R-HSA-162582", "R-HSA-192105", "R-HSA-193368", "R-HSA-193775", "R-HSA-193807", "R-HSA-194068", "R-HSA-196854", "R-HSA-2187338", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-556833", "R-HSA-6806667", "R-HSA-8957322", "R-HSA-975634", "kegg_path:hsa00120", "kegg_path:hsa00140", "kegg_path:hsa01100", "R-HSA-1430728", "R-HSA-162582", "R-HSA-192105", "R-HSA-193368", "R-HSA-193775", "R-HSA-193807", "R-HSA-194068", "R-HSA-196854", "R-HSA-2187338", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-556833", "R-HSA-6806667", "R-HSA-8957322", "R-HSA-975634" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P17516", "ensembl_id": "None", "entrez_id": "ENSG00000198610", "chromosome_number": "10", "lastmodified": "2023-05-16T12:02:33.621158" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3228" }, { "type": "SmallVariant", "id": "3244" }, { "type": "SmallVariant", "id": "3291" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKR1C4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "1079" }, { "type": "GeneCombination", "id": "1087" }, { "type": "GeneCombination", "id": "1107" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKR1C4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C4/?format=api" } }, { "type": "Gene", "id": "CYB5A", "attributes": { "go_molecular_function": [ "['enzyme binding', 'heme binding', 'protein binding', 'metal ion binding', 'cytochrome-c oxidase activity']" ], "pathway_id": [ "R-HSA-1430728", "R-HSA-196836", "R-HSA-196849", "R-HSA-196854" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P00167", "ensembl_id": "None", "entrez_id": "ENSG00000166347", "chromosome_number": "18", "lastmodified": "2023-05-16T12:02:33.617165" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3226" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYB5A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYB5A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1079" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYB5A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYB5A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CYB5A/?format=api" } }, { "type": "Gene", "id": "FLRT3", "attributes": { "go_molecular_function": [ "['protein homodimerization activity', 'protein-macromolecule adaptor activity', 'protein binding', 'fibroblast growth factor receptor binding', 'chemorepellent activity']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-162582", "R-HSA-190236", "R-HSA-376176", "R-HSA-422475", "R-HSA-5654687", "R-HSA-5654736", "R-HSA-9006934", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NZU0", "ensembl_id": "None", "entrez_id": "ENSG00000125848", "chromosome_number": "20", "lastmodified": "2021-10-18T11:00:44.905326" }, "relationships": { "variant_set": { "meta": { "count": 11 }, "data": [ { "type": "SmallVariant", "id": "805" }, { "type": "SmallVariant", "id": "806" }, { "type": "SmallVariant", "id": "815" }, { "type": "SmallVariant", "id": "2682" }, { "type": "SmallVariant", "id": "2695" }, { "type": "SmallVariant", "id": "2730" }, { "type": "SmallVariant", "id": "3194" }, { "type": "SmallVariant", "id": "3225" }, { "type": "SmallVariant", "id": "3234" }, { "type": "SmallVariant", "id": "3258" }, { "type": "SmallVariant", "id": "3474" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLRT3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLRT3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 9 }, "data": [ { "type": "GeneCombination", "id": "252" }, { "type": "GeneCombination", "id": "256" }, { "type": "GeneCombination", "id": "897" }, { "type": "GeneCombination", "id": "909" }, { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1079" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1094" }, { "type": "GeneCombination", "id": "1166" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLRT3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLRT3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FLRT3/?format=api" } }, { "type": "Gene", "id": "HSD17B6", "attributes": { "go_molecular_function": [ "['17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'androstan-3-alpha,17-beta-diol dehydrogenase activity', '5alpha-androstane-3beta,17beta-diol dehydrogenase activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity', 'testosterone dehydrogenase (NAD+) activity', '17-beta-hydroxysteroid dehydrogenase (NAD+) activity', 'NAD-retinol dehydrogenase activity', 'electron transfer activity', 'oxidoreductase activity', 'catalytic activity', 'androsterone dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa00830", "kegg_path:hsa01100", "kegg_path:hsa01240", "kegg_path:hsa00140", "kegg_path:hsa00830", "kegg_path:hsa01100", "kegg_path:hsa01240", "R-HSA-162582", "R-HSA-2187338", "R-HSA-2453902", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O14756", "ensembl_id": "None", "entrez_id": "ENSG00000025423", "chromosome_number": "12", "lastmodified": "2023-05-16T12:02:33.587797" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3207" }, { "type": "SmallVariant", "id": "3227" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "1072" }, { "type": "GeneCombination", "id": "1079" }, { "type": "GeneCombination", "id": "1098" }, { "type": "GeneCombination", "id": "1101" }, { "type": "GeneCombination", "id": "1116" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B6/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }