Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/386/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CACNG4", "attributes": { "go_molecular_function": [ "ionotropic glutamate receptor binding", "voltage-gated calcium channel activity" ], "pathway_id": [ "R-HSA-399721", "R-HSA-5576892", "kegg_path:hsa04261", "R-HSA-112314", "kegg_path:hsa05414", "kegg_path:hsa04010", "kegg_path:hsa05412", "kegg_path:hsa04921", "kegg_path:hsa05410", "kegg_path:hsa05412", "R-HSA-1266738", "R-HSA-5576891", "kegg_path:hsa05410", "kegg_path:hsa04921", "kegg_path:hsa04260", "R-HSA-112315", "R-HSA-112316", "R-HSA-397014", "R-HSA-112308", "R-HSA-5682910", "kegg_path:hsa04260", "R-HSA-5576893", "kegg_path:hsa05414", "kegg_path:hsa04010", "kegg_path:hsa04261", "R-HSA-399719" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9UBN1", "ensembl_id": "ENSG00000075461", "entrez_id": "27092", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.642749" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1207" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CACNG4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CACNG4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "386" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CACNG4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CACNG4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CACNG4/?format=api" } }, { "type": "Gene", "id": "FBLN2", "attributes": { "go_molecular_function": [ "extracellular matrix binding", "extracellular matrix structural constituent", "protein binding", "calcium ion binding" ], "pathway_id": [ "R-HSA-1566948", "R-HSA-2129379", "R-HSA-1474244" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P98095", "ensembl_id": "ENSG00000163520", "entrez_id": "2199", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.617417" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1208" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FBLN2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FBLN2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "386" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FBLN2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FBLN2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FBLN2/?format=api" } }, { "type": "Gene", "id": "NAV1", "attributes": { "go_molecular_function": [ "protein binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q8NEY1", "ensembl_id": "ENSG00000134369", "entrez_id": "89796", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.762511" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1209" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NAV1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NAV1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "386" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NAV1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NAV1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NAV1/?format=api" } }, { "type": "Gene", "id": "NR5A1", "attributes": { "go_molecular_function": [ "['DNA binding', 'chromatin binding', 'zinc ion binding', 'enzyme binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'nuclear receptor activity', 'protein binding', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding', 'sequence-specific DNA binding', 'phospholipid binding', 'transcription coregulator binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04927", "kegg_path:hsa04934", "kegg_path:hsa04927", "kegg_path:hsa04934", "R-HSA-1266738", "R-HSA-212436", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-383280", "R-HSA-392499", "R-HSA-4090294", "R-HSA-452723", "R-HSA-597592", "R-HSA-73857", "R-HSA-74160", "R-HSA-9690406" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13285", "ensembl_id": "None", "entrez_id": "ENSG00000136931", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.221369" }, "relationships": { "variant_set": { "meta": { "count": 19 }, "data": [ { "type": "SmallVariant", "id": "861" }, { "type": "SmallVariant", "id": "863" }, { "type": "SmallVariant", "id": "1197" }, { "type": "SmallVariant", "id": "1199" }, { "type": "SmallVariant", "id": "1206" }, { "type": "SmallVariant", "id": "1214" }, { "type": "SmallVariant", "id": "1442" }, { "type": "SmallVariant", "id": "1445" }, { "type": "SmallVariant", "id": "1697" }, { "type": "SmallVariant", "id": "2169" }, { "type": "SmallVariant", "id": "2269" }, { "type": "SmallVariant", "id": "2278" }, { "type": "SmallVariant", "id": "3160" }, { "type": "SmallVariant", "id": "3257" }, { "type": "SmallVariant", "id": "3272" }, { "type": "SmallVariant", "id": "3275" }, { "type": "SmallVariant", "id": "3411" }, { "type": "SmallVariant", "id": "3413" }, { "type": "SmallVariant", "id": "3667" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR5A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "268" }, { "type": "GeneCombination", "id": "267" }, { "type": "GeneCombination", "id": "384" }, { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "459" }, { "type": "GeneCombination", "id": "460" }, { "type": "GeneCombination", "id": "554" }, { "type": "GeneCombination", "id": "738" }, { "type": "GeneCombination", "id": "766" }, { "type": "GeneCombination", "id": "763" }, { "type": "GeneCombination", "id": "1055" }, { "type": "GeneCombination", "id": "1094" }, { "type": "GeneCombination", "id": "1101" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1144" }, { "type": "GeneCombination", "id": "1235" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR5A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/?format=api" } }, { "type": "Gene", "id": "SMAD6", "attributes": { "go_molecular_function": [ "['chromatin binding', 'R-SMAD binding', 'co-SMAD binding', 'I-SMAD binding', 'transcription cis-regulatory region binding', 'type I activin receptor binding', 'type I transforming growth factor beta receptor binding', 'protein binding', 'metal ion binding', 'transcription regulator inhibitor activity', 'ubiquitin protein ligase binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04350", "R-HSA-162582", "R-HSA-201451", "R-HSA-212436", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8941326", "R-HSA-9006936" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O43541", "ensembl_id": "None", "entrez_id": "ENSG00000137834", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.832989" }, "relationships": { "variant_set": { "meta": { "count": 12 }, "data": [ { "type": "SmallVariant", "id": "1210" }, { "type": "SmallVariant", "id": "2858" }, { "type": "SmallVariant", "id": "2859" }, { "type": "SmallVariant", "id": "2860" }, { "type": "SmallVariant", "id": "2861" }, { "type": "SmallVariant", "id": "2862" }, { "type": "SmallVariant", "id": "2863" }, { "type": "SmallVariant", "id": "2864" }, { "type": "SmallVariant", "id": "2865" }, { "type": "SmallVariant", "id": "2866" }, { "type": "SmallVariant", "id": "2867" }, { "type": "SmallVariant", "id": "2868" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMAD6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMAD6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "951" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMAD6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMAD6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SMAD6/?format=api" } }, { "type": "Gene", "id": "SRA1", "attributes": { "go_molecular_function": [ "['steroid receptor RNA activator RNA binding', 'nuclear receptor coactivator activity', 'transcription coactivator activity', 'DNA binding', 'protein binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9HD15", "ensembl_id": "None", "entrez_id": "ENSG00000213523", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.268998" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "35" }, { "type": "SmallVariant", "id": "1211" }, { "type": "SmallVariant", "id": "1424" }, { "type": "SmallVariant", "id": "2777" }, { "type": "SmallVariant", "id": "3299" }, { "type": "SmallVariant", "id": "3301" }, { "type": "SmallVariant", "id": "3305" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SRA1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SRA1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "14" }, { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "448" }, { "type": "GeneCombination", "id": "928" }, { "type": "GeneCombination", "id": "1109" }, { "type": "GeneCombination", "id": "1110" }, { "type": "GeneCombination", "id": "1112" }, { "type": "GeneCombination", "id": "1124" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SRA1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SRA1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SRA1/?format=api" } }, { "type": "Gene", "id": "ZDHHC11", "attributes": { "go_molecular_function": [ "protein binding", "transferase activity", "protein-cysteine S-palmitoyltransferase activity", "acyltransferase activity", "signaling adaptor activity", "palmitoyltransferase activity" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9H8X9", "ensembl_id": "ENSG00000188818", "entrez_id": "79844", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.880476" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1212" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZDHHC11/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZDHHC11/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "386" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZDHHC11/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZDHHC11/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZDHHC11/?format=api" } }, { "type": "Gene", "id": "ZFPM2", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'transcription coactivator activity', 'DNA binding', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'protein binding', 'transcription corepressor activity']" ], "pathway_id": [ "kegg_path:hsa05206", "R-HSA-109582", "R-HSA-1266738", "R-HSA-9690406", "R-HSA-983231" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8WW38", "ensembl_id": "None", "entrez_id": "ENSG00000169946", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.324439" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "862" }, { "type": "SmallVariant", "id": "1213" }, { "type": "SmallVariant", "id": "1446" }, { "type": "SmallVariant", "id": "3216" }, { "type": "SmallVariant", "id": "3250" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZFPM2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZFPM2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "267" }, { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "689" }, { "type": "GeneCombination", "id": "1075" }, { "type": "GeneCombination", "id": "1090" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZFPM2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZFPM2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZFPM2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 8 } }