Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/760/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ADAMTS16", "attributes": { "go_molecular_function": [ "['metalloendopeptidase activity', 'metal ion binding']" ], "pathway_id": [ "R-HSA-1474228", "R-HSA-1474244", "R-HSA-1643685", "R-HSA-3781865", "R-HSA-3906995", "R-HSA-392499", "R-HSA-5083635", "R-HSA-5173105", "R-HSA-5173214", "R-HSA-5668914", "R-HSA-597592" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q8TE57", "ensembl_id": "None", "entrez_id": "ENSG00000145536", "chromosome_number": "5", "lastmodified": "2022-08-04T14:14:58.302365" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2255" }, { "type": "SmallVariant", "id": "3701" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADAMTS16/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADAMTS16/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "760" }, { "type": "GeneCombination", "id": "1252" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADAMTS16/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADAMTS16/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ADAMTS16/?format=api" } }, { "type": "Gene", "id": "ATM", "attributes": { "go_molecular_function": [ "DNA-dependent protein kinase activity", "protein binding", "identical protein binding", "protein serine/threonine kinase activity", "DNA binding", "1-phosphatidylinositol-3-kinase activity", "protein serine/threonine/tyrosine kinase activity", "protein N-terminus binding", "ATP binding", "protein serine kinase activity", "protein-containing complex binding" ], "pathway_id": [ "kegg_path:hsa04210", "R-HSA-2559583", "kegg_path:hsa05202", "kegg_path:hsa05206", "R-HSA-1474165", "kegg_path:hsa01524", "R-HSA-5693565", "R-HSA-5693568", "kegg_path:hsa04064", "kegg_path:hsa04068", "R-HSA-5693537", "kegg_path:hsa05170", "R-HSA-73857", "R-HSA-69580", "kegg_path:hsa05165", "R-HSA-5693616", "R-HSA-9663891", "R-HSA-5685938", "R-HSA-912446", "kegg_path:hsa04115", "R-HSA-6803204", "R-HSA-6803207", "R-HSA-3371556", "R-HSA-5693606", "R-HSA-212436", "R-HSA-1640170", "R-HSA-3371453", "kegg_path:hsa04115", "R-HSA-5693548", "R-HSA-349425", "R-HSA-5693607", "kegg_path:hsa05165", "R-HSA-5633007", "R-HSA-5693554", "R-HSA-6804757", "R-HSA-69615", "R-HSA-6804756", "R-HSA-73894", "R-HSA-6806003", "kegg_path:hsa04110", "R-HSA-5693571", "R-HSA-6804760", "R-HSA-69541", "R-HSA-9664873", "kegg_path:hsa04110", "R-HSA-2559586", "R-HSA-5693538", "R-HSA-69563", "kegg_path:hsa05166", "R-HSA-8953897", "R-HSA-1500620", "R-HSA-5633008", "R-HSA-5693532", "R-HSA-6796648", "R-HSA-74160", "kegg_path:hsa04218", "kegg_path:hsa03440", "kegg_path:hsa05131", "R-HSA-2262752", "kegg_path:hsa04218", "R-HSA-3700989", "R-HSA-5685942", "kegg_path:hsa05131", "kegg_path:hsa03440", "R-HSA-1632852", "R-HSA-69481", "kegg_path:hsa05166", "R-HSA-9612973", "R-HSA-5693579", "kegg_path:hsa05170", "R-HSA-69473", "kegg_path:hsa04064", "kegg_path:hsa04068", "kegg_path:hsa05206", "R-HSA-69620", "kegg_path:hsa01524", "R-HSA-5693567", "kegg_path:hsa05202", "kegg_path:hsa04210" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q13315", "ensembl_id": "ENSG00000149311", "entrez_id": "472", "chromosome_number": "11", "lastmodified": "2022-08-04T14:14:58.235652" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2253" }, { "type": "SmallVariant", "id": "2294" }, { "type": "SmallVariant", "id": "2313" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATM/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATM/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "760" }, { "type": "GeneCombination", "id": "770" }, { "type": "GeneCombination", "id": "777" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATM/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATM/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ATM/?format=api" } }, { "type": "Gene", "id": "BLM", "attributes": { "go_molecular_function": [ "protein homodimerization activity", "telomeric D-loop binding", "bubble DNA binding", "3'-5' DNA helicase activity", "helicase activity", "single-stranded DNA binding", "protein binding", "identical protein binding", "Y-form DNA binding", "forked DNA-dependent helicase activity", "p53 binding", "DNA binding", "four-way junction helicase activity", "DNA helicase activity", "ATP-dependent activity, acting on DNA", "telomeric G-quadruplex DNA binding", "DNA/DNA annealing activity", "ATP hydrolysis activity", "8-hydroxy-2'-deoxyguanosine DNA binding", "four-way junction DNA binding", "G-quadruplex DNA binding", "ATP binding", "zinc ion binding" ], "pathway_id": [ "R-HSA-174414", "R-HSA-5693538", "R-HSA-73857", "R-HSA-174417", "R-HSA-6804756", "R-HSA-157579", "R-HSA-5693579", "R-HSA-69473", "R-HSA-73894", "R-HSA-3108214", "R-HSA-392499", "R-HSA-1474165", "R-HSA-5693568", "R-HSA-212436", "R-HSA-3700989", "R-HSA-5685942", "kegg_path:hsa03440", "R-HSA-1640170", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-69481", "R-HSA-73886", "R-HSA-5693607", "R-HSA-5633007", "R-HSA-5693554", "R-HSA-5693616", "R-HSA-1500620", "R-HSA-5685938", "R-HSA-5693532", "kegg_path:hsa03460", "R-HSA-74160", "R-HSA-912446", "R-HSA-180786", "R-HSA-597592", "R-HSA-69620", "R-HSA-5693537", "R-HSA-5693567" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P54132", "ensembl_id": "ENSG00000197299", "entrez_id": "641", "chromosome_number": "15", "lastmodified": "2022-08-04T14:14:58.652783" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2254" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BLM/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BLM/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "760" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BLM/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BLM/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/BLM/?format=api" } }, { "type": "Gene", "id": "CYP21A2", "attributes": { "go_molecular_function": [ "iron ion binding", "steroid binding", "steroid 21-monooxygenase activity", "steroid hydroxylase activity", "17-hydroxyprogesterone 21-hydroxylase activity", "heme binding", "progesterone 21-hydroxylase activity" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa04934", "kegg_path:hsa04927", "R-HSA-5579021", "R-HSA-8957322", "kegg_path:hsa04925", "kegg_path:hsa00140", "R-HSA-193993", "R-HSA-1430728", "R-HSA-211945", "kegg_path:hsa01100", "R-HSA-211859", "kegg_path:hsa04925", "R-HSA-5668914", "kegg_path:hsa04934", "kegg_path:hsa00140", "R-HSA-211976", "R-HSA-211897", "kegg_path:hsa01100", "kegg_path:hsa04934", "kegg_path:hsa01100", "kegg_path:hsa04927", "R-HSA-211897", "R-HSA-1643685", "R-HSA-5579029", "R-HSA-211976", "kegg_path:hsa00140", "kegg_path:hsa04925", "kegg_path:hsa04934", "R-HSA-556833", "kegg_path:hsa04927", "R-HSA-5668914", "kegg_path:hsa04934", "R-HSA-1643685", "R-HSA-5579029", "kegg_path:hsa04927", "R-HSA-194002", "kegg_path:hsa04934", "kegg_path:hsa01100", "kegg_path:hsa00140", "kegg_path:hsa04927", "R-HSA-5668914", "R-HSA-556833", "R-HSA-556833", "kegg_path:hsa04925", "kegg_path:hsa01100", "R-HSA-194002", "R-HSA-211897", "kegg_path:hsa04927", "R-HSA-211976", "kegg_path:hsa01100", "kegg_path:hsa04934", "R-HSA-1430728", "R-HSA-196071", "R-HSA-8957322", "kegg_path:hsa04925", "R-HSA-5579021", "R-HSA-211859", "kegg_path:hsa04925", "kegg_path:hsa00140", "kegg_path:hsa01100", "kegg_path:hsa04934", "kegg_path:hsa04934", "kegg_path:hsa00140", "R-HSA-211859", "kegg_path:hsa04925", "R-HSA-5579021", "R-HSA-211945", "kegg_path:hsa04927", "kegg_path:hsa00140", "R-HSA-193993", "R-HSA-8957322", "R-HSA-1430728", "R-HSA-196071", "kegg_path:hsa01100", "R-HSA-211945", "kegg_path:hsa00140", "R-HSA-193993", "kegg_path:hsa04925", "R-HSA-196071", "kegg_path:hsa04927", "kegg_path:hsa04927", "kegg_path:hsa01100", "kegg_path:hsa04925", "R-HSA-1643685", "R-HSA-5579029", "R-HSA-194002" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q16874", "ensembl_id": "ENSG00000231852", "entrez_id": "1589", "chromosome_number": "6", "lastmodified": "2022-08-04T14:14:57.592960" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2252" }, { "type": "SmallVariant", "id": "2339" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYP21A2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYP21A2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "760" }, { "type": "GeneCombination", "id": "789" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYP21A2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYP21A2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CYP21A2/?format=api" } }, { "type": "Gene", "id": "FSHR", "attributes": { "go_molecular_function": [ "['follicle-stimulating hormone receptor activity', 'G protein-coupled peptide receptor activity', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa04024", "kegg_path:hsa04080", "kegg_path:hsa04913", "kegg_path:hsa04024", "kegg_path:hsa04080", "kegg_path:hsa04913", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373076", "R-HSA-375281", "R-HSA-388396", "R-HSA-418555", "R-HSA-500792", "R-HSA-5663205", "R-HSA-9658195", "R-HSA-9660821", "R-HSA-9662851", "R-HSA-9664433" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "A0A1D5RMN4", "ensembl_id": "None", "entrez_id": "ENSG00000170820", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.419525" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1202" }, { "type": "SmallVariant", "id": "2256" }, { "type": "SmallVariant", "id": "2284" }, { "type": "SmallVariant", "id": "3657" }, { "type": "SmallVariant", "id": "3658" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FSHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FSHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "760" }, { "type": "GeneCombination", "id": "767" }, { "type": "GeneCombination", "id": "1230" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FSHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FSHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FSHR/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }