Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1180/genes/?format=api
{ "data": [ { "type": "Gene", "id": "BBS1", "attributes": { "go_molecular_function": [ "['protein binding', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'smoothened binding', 'patched binding']" ], "pathway_id": [ "R-HSA-1852241", "R-HSA-5617833", "R-HSA-5620920", "R-HSA-5620922" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8NFJ9", "ensembl_id": "None", "entrez_id": "ENSG00000174483", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.590671" }, "relationships": { "variant_set": { "meta": { "count": 32 }, "data": [ { "type": "SmallVariant", "id": "129" }, { "type": "SmallVariant", "id": "181" }, { "type": "CopyNumberVariant", "id": "1358" }, { "type": "CopyNumberVariant", "id": "1359" }, { "type": "CopyNumberVariant", "id": "1360" }, { "type": "SmallVariant", "id": "2416" }, { "type": "SmallVariant", "id": "79" }, { "type": "SmallVariant", "id": "80" }, { "type": "SmallVariant", "id": "82" }, { "type": "SmallVariant", "id": "121" }, { "type": "SmallVariant", "id": "124" }, { "type": "SmallVariant", "id": "159" }, { "type": "SmallVariant", "id": "163" }, { "type": "SmallVariant", "id": "183" }, { "type": "SmallVariant", "id": "288" }, { "type": "SmallVariant", "id": "300" }, { "type": "SmallVariant", "id": "628" }, { "type": "SmallVariant", "id": "629" }, { "type": "SmallVariant", "id": "630" }, { "type": "SmallVariant", "id": "2409" }, { "type": "SmallVariant", "id": "2410" }, { "type": "SmallVariant", "id": "2411" }, { "type": "SmallVariant", "id": "2412" }, { "type": "SmallVariant", "id": "2420" }, { "type": "SmallVariant", "id": "2467" }, { "type": "SmallVariant", "id": "3021" }, { "type": "SmallVariant", "id": "3023" }, { "type": "SmallVariant", "id": "3024" }, { "type": "SmallVariant", "id": "3025" }, { "type": "SmallVariant", "id": "3026" }, { "type": "SmallVariant", "id": "3033" }, { "type": "SmallVariant", "id": "3502" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BBS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BBS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 20 }, "data": [ { "type": "GeneCombination", "id": "32" }, { "type": "GeneCombination", "id": "44" }, { "type": "GeneCombination", "id": "46" }, { "type": "GeneCombination", "id": "57" }, { "type": "GeneCombination", "id": "58" }, { "type": "GeneCombination", "id": "64" }, { "type": "GeneCombination", "id": "104" }, { "type": "GeneCombination", "id": "105" }, { "type": "GeneCombination", "id": "213" }, { "type": "GeneCombination", "id": "423" }, { "type": "GeneCombination", "id": "1010" }, { "type": "GeneCombination", "id": "1011" }, { "type": "GeneCombination", "id": "45" }, { "type": "GeneCombination", "id": "1014" }, { "type": "GeneCombination", "id": "1013" }, { "type": "GeneCombination", "id": "1180" }, { "type": "GeneCombination", "id": "1012" }, { "type": "GeneCombination", "id": "424" }, { "type": "GeneCombination", "id": "43" }, { "type": "GeneCombination", "id": "834" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BBS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BBS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/BBS1/?format=api" } }, { "type": "Gene", "id": "IFT172", "attributes": { "go_molecular_function": [], "pathway_id": [ "R-HSA-162582", "R-HSA-1852241", "R-HSA-5358351", "R-HSA-5610787", "R-HSA-5617833", "R-HSA-5620924" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9UG01", "ensembl_id": "None", "entrez_id": "ENSG00000138002", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.331851" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "1482" }, { "type": "SmallVariant", "id": "2002" }, { "type": "SmallVariant", "id": "2005" }, { "type": "SmallVariant", "id": "3028" }, { "type": "SmallVariant", "id": "3029" }, { "type": "SmallVariant", "id": "3041" }, { "type": "SmallVariant", "id": "3477" }, { "type": "SmallVariant", "id": "3499" }, { "type": "SmallVariant", "id": "3504" }, { "type": "SmallVariant", "id": "3692" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IFT172/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IFT172/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 9 }, "data": [ { "type": "GeneCombination", "id": "474" }, { "type": "GeneCombination", "id": "691" }, { "type": "GeneCombination", "id": "690" }, { "type": "GeneCombination", "id": "1010" }, { "type": "GeneCombination", "id": "1018" }, { "type": "GeneCombination", "id": "1168" }, { "type": "GeneCombination", "id": "1178" }, { "type": "GeneCombination", "id": "1180" }, { "type": "GeneCombination", "id": "1248" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IFT172/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IFT172/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IFT172/?format=api" } }, { "type": "Gene", "id": "TRIM32", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'ubiquitin binding', 'ubiquitin-protein transferase activity', 'protein self-association', 'translation initiation factor binding', 'protein binding', 'RNA binding', 'transcription coactivator activity', 'myosin binding', 'ubiquitin protein ligase activity', 'Tat protein binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04120", "kegg_path:hsa04120", "R-HSA-1280218", "R-HSA-168249", "R-HSA-168256", "R-HSA-1834949", "R-HSA-3134975", "R-HSA-983168", "R-HSA-983169" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q13049", "ensembl_id": "None", "entrez_id": "ENSG00000119401", "chromosome_number": "9", "lastmodified": "2022-08-04T14:14:59.119875" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2442" }, { "type": "SmallVariant", "id": "3053" }, { "type": "SmallVariant", "id": "3503" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TRIM32/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TRIM32/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "822" }, { "type": "GeneCombination", "id": "1023" }, { "type": "GeneCombination", "id": "1180" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TRIM32/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TRIM32/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TRIM32/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }