Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1076/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AKR1C3", "attributes": { "go_molecular_function": [ "['geranylgeranyl reductase activity', '15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity', 'ketosteroid monooxygenase activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity', 'androsterone dehydrogenase activity', '17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'ketoreductase activity', 'steroid dehydrogenase activity', 'D-threo-aldose 1-dehydrogenase activity', 'oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor', 'prostaglandin-F synthase activity', '17-beta-hydroxysteroid dehydrogenase (NAD+) activity', 'dihydrotestosterone 17-beta-dehydrogenase activity', 'phenanthrene 9,10-monooxygenase activity', 'prostaglandin H2 endoperoxidase reductase activity', 'delta4-3-oxosteroid 5beta-reductase activity', '5alpha-androstane-3beta,17beta-diol dehydrogenase activity', 'NAD-retinol dehydrogenase activity', 'bile acid binding', 'alditol:NADP+ 1-oxidoreductase activity', 'retinal dehydrogenase activity', 'NADP-retinol dehydrogenase activity', 'testosterone dehydrogenase (NAD+) activity', 'prostaglandin D2 11-ketoreductase activity', 'aldo-keto reductase (NADP) activity', 'androstan-3-alpha,17-beta-diol dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa00590", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa04913", "kegg_path:hsa00140", "kegg_path:hsa00590", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa04913", "R-HSA-1430728", "R-HSA-162582", "R-HSA-192105", "R-HSA-193368", "R-HSA-193775", "R-HSA-193807", "R-HSA-194068", "R-HSA-196854", "R-HSA-2142753", "R-HSA-2162123", "R-HSA-2187338", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-5362517", "R-HSA-5365859", "R-HSA-556833", "R-HSA-6806667", "R-HSA-8957322", "R-HSA-8978868", "R-HSA-9006931", "R-HSA-975634", "kegg_path:hsa00140", "kegg_path:hsa00590", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa04913", "kegg_path:hsa00140", "kegg_path:hsa00590", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa04913", "R-HSA-1430728", "R-HSA-162582", "R-HSA-192105", "R-HSA-193368", "R-HSA-193775", "R-HSA-193807", "R-HSA-194068", "R-HSA-196854", "R-HSA-2142753", "R-HSA-2162123", "R-HSA-2187338", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-5362517", "R-HSA-5365859", "R-HSA-556833", "R-HSA-6806667", "R-HSA-8957322", "R-HSA-8978868", "R-HSA-9006931", "R-HSA-975634" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P42330", "ensembl_id": "None", "entrez_id": "ENSG00000196139", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.479228" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1200" }, { "type": "SmallVariant", "id": "3220" }, { "type": "SmallVariant", "id": "3245" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKR1C3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "1076" }, { "type": "GeneCombination", "id": "1087" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKR1C3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C3/?format=api" } }, { "type": "Gene", "id": "BBS7", "attributes": { "go_molecular_function": [ "['RNA polymerase II-specific DNA-binding transcription factor binding', 'protein binding']" ], "pathway_id": [ "R-HSA-1852241", "R-HSA-5617833", "R-HSA-5620920", "R-HSA-5620922" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q8IWZ6", "ensembl_id": "None", "entrez_id": "ENSG00000138686", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.514609" }, "relationships": { "variant_set": { "meta": { "count": 16 }, "data": [ { "type": "CopyNumberVariant", "id": "1363" }, { "type": "SmallVariant", "id": "122" }, { "type": "SmallVariant", "id": "198" }, { "type": "SmallVariant", "id": "199" }, { "type": "SmallVariant", "id": "201" }, { "type": "SmallVariant", "id": "1357" }, { "type": "SmallVariant", "id": "1361" }, { "type": "SmallVariant", "id": "1365" }, { "type": "SmallVariant", "id": "2423" }, { "type": "SmallVariant", "id": "3030" }, { "type": "SmallVariant", "id": "3044" }, { "type": "SmallVariant", "id": "3045" }, { "type": "SmallVariant", "id": "3218" }, { "type": "SmallVariant", "id": "3303" }, { "type": "SmallVariant", "id": "3509" }, { "type": "SmallVariant", "id": "3511" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BBS7/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BBS7/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 12 }, "data": [ { "type": "GeneCombination", "id": "72" }, { "type": "GeneCombination", "id": "73" }, { "type": "GeneCombination", "id": "108" }, { "type": "GeneCombination", "id": "423" }, { "type": "GeneCombination", "id": "425" }, { "type": "GeneCombination", "id": "426" }, { "type": "GeneCombination", "id": "1076" }, { "type": "GeneCombination", "id": "1111" }, { "type": "GeneCombination", "id": "1182" }, { "type": "GeneCombination", "id": "1183" }, { "type": "GeneCombination", "id": "1020" }, { "type": "GeneCombination", "id": "43" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BBS7/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BBS7/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/BBS7/?format=api" } }, { "type": "Gene", "id": "GHR", "attributes": { "go_molecular_function": [ "['peptide hormone binding', 'proline-rich region binding', 'SH2 domain binding', 'growth hormone receptor activity', 'protein kinase binding', 'cytokine binding', 'protein phosphatase binding', 'protein binding', 'growth factor binding', 'protein homodimerization activity', 'cytokine receptor activity', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04060", "kegg_path:hsa04080", "kegg_path:hsa04151", "kegg_path:hsa04630", "kegg_path:hsa04935", "R-HSA-1170546", "R-HSA-1280215", "R-HSA-168256", "R-HSA-982772" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10912", "ensembl_id": "None", "entrez_id": "ENSG00000112964", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.556257" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "1957" }, { "type": "SmallVariant", "id": "1967" }, { "type": "SmallVariant", "id": "3219" }, { "type": "SmallVariant", "id": "3222" }, { "type": "SmallVariant", "id": "3232" }, { "type": "SmallVariant", "id": "3249" }, { "type": "SmallVariant", "id": "3269" }, { "type": "SmallVariant", "id": "3279" }, { "type": "SmallVariant", "id": "3330" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 10 }, "data": [ { "type": "GeneCombination", "id": "669" }, { "type": "GeneCombination", "id": "674" }, { "type": "GeneCombination", "id": "1076" }, { "type": "GeneCombination", "id": "1077" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1089" }, { "type": "GeneCombination", "id": "1099" }, { "type": "GeneCombination", "id": "1103" }, { "type": "GeneCombination", "id": "1123" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/?format=api" } }, { "type": "Gene", "id": "GNRHR", "attributes": { "go_molecular_function": [ "['peptide binding', 'G protein-coupled receptor activity', 'gonadotropin-releasing hormone receptor activity']" ], "pathway_id": [ "kegg_path:hsa04080", "kegg_path:hsa04912", "R-HSA-162582", "R-HSA-372790", "R-HSA-373076", "R-HSA-375281", "R-HSA-388396", "R-HSA-416476", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P30968", "ensembl_id": "None", "entrez_id": "ENSG00000109163", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.928979" }, "relationships": { "variant_set": { "meta": { "count": 21 }, "data": [ { "type": "SmallVariant", "id": "330" }, { "type": "SmallVariant", "id": "380" }, { "type": "SmallVariant", "id": "381" }, { "type": "SmallVariant", "id": "387" }, { "type": "SmallVariant", "id": "391" }, { "type": "SmallVariant", "id": "401" }, { "type": "SmallVariant", "id": "915" }, { "type": "SmallVariant", "id": "1716" }, { "type": "SmallVariant", "id": "2504" }, { "type": "SmallVariant", "id": "2505" }, { "type": "SmallVariant", "id": "2507" }, { "type": "SmallVariant", "id": "2508" }, { "type": "SmallVariant", "id": "2685" }, { "type": "SmallVariant", "id": "2690" }, { "type": "SmallVariant", "id": "2905" }, { "type": "SmallVariant", "id": "2909" }, { "type": "SmallVariant", "id": "3364" }, { "type": "SmallVariant", "id": "3365" }, { "type": "SmallVariant", "id": "3369" }, { "type": "SmallVariant", "id": "3370" }, { "type": "SmallVariant", "id": "3383" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GNRHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GNRHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 26 }, "data": [ { "type": "GeneCombination", "id": "133" }, { "type": "GeneCombination", "id": "116" }, { "type": "GeneCombination", "id": "287" }, { "type": "GeneCombination", "id": "563" }, { "type": "GeneCombination", "id": "619" }, { "type": "GeneCombination", "id": "633" }, { "type": "GeneCombination", "id": "659" }, { "type": "GeneCombination", "id": "665" }, { "type": "GeneCombination", "id": "1076" }, { "type": "GeneCombination", "id": "849" }, { "type": "GeneCombination", "id": "872" }, { "type": "GeneCombination", "id": "130" }, { "type": "GeneCombination", "id": "894" }, { "type": "GeneCombination", "id": "895" }, { "type": "GeneCombination", "id": "905" }, { "type": "GeneCombination", "id": "909" }, { "type": "GeneCombination", "id": "955" }, { "type": "GeneCombination", "id": "957" }, { "type": "GeneCombination", "id": "963" }, { "type": "GeneCombination", "id": "965" }, { "type": "GeneCombination", "id": "980" }, { "type": "GeneCombination", "id": "1062" }, { "type": "GeneCombination", "id": "850" }, { "type": "GeneCombination", "id": "848" }, { "type": "GeneCombination", "id": "1130" }, { "type": "GeneCombination", "id": "1134" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GNRHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GNRHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GNRHR/?format=api" } }, { "type": "Gene", "id": "PLXNA3", "attributes": { "go_molecular_function": [ "['semaphorin receptor activity', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa04360", "R-HSA-1266738", "R-HSA-373755", "R-HSA-399954", "R-HSA-399955", "R-HSA-399956", "R-HSA-422475", "R-HSA-9675108", "kegg_path:hsa04360", "R-HSA-1266738", "R-HSA-373755", "R-HSA-399954", "R-HSA-399955", "R-HSA-399956", "R-HSA-422475", "R-HSA-9675108" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P51805", "ensembl_id": "None", "entrez_id": "ENSG00000130827", "chromosome_number": "X", "lastmodified": "2023-05-16T12:02:33.541810" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3176" }, { "type": "SmallVariant", "id": "3211" }, { "type": "SmallVariant", "id": "3217" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PLXNA3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PLXNA3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1073" }, { "type": "GeneCombination", "id": "1076" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PLXNA3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PLXNA3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PLXNA3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }