Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/269/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ALMS1", "attributes": { "go_molecular_function": [ "['molecular_function', 'microtubule binding']" ], "pathway_id": [ "R-HSA-1640170", "R-HSA-1852241", "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380287", "R-HSA-380320", "R-HSA-453274", "R-HSA-5617833", "R-HSA-5620912", "R-HSA-68877", "R-HSA-68886", "R-HSA-69275", "R-HSA-69278", "R-HSA-8854518" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000116127", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.597776" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "CopyNumberVariant", "id": "1352" }, { "type": "SmallVariant", "id": "865" }, { "type": "SmallVariant", "id": "3031" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALMS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALMS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "269" }, { "type": "GeneCombination", "id": "421" }, { "type": "GeneCombination", "id": "1011" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALMS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALMS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ALMS1/?format=api" } }, { "type": "Gene", "id": "BMP4", "attributes": { "go_molecular_function": [ "['growth factor activity', 'BMP receptor binding', 'protein binding', 'chemoattractant activity', 'heparin binding', 'co-receptor binding', 'cytokine activity']" ], "pathway_id": [ "kegg_path:hsa04060", "kegg_path:hsa04350", "kegg_path:hsa04390", "kegg_path:hsa04550", "kegg_path:hsa04919", "kegg_path:hsa05200", "kegg_path:hsa05217", "kegg_path:hsa05418", "R-HSA-1474244", "R-HSA-1566948", "R-HSA-2129379", "R-HSA-381426", "R-HSA-392499", "R-HSA-597592", "R-HSA-8957275", "kegg_path:hsa04060", "kegg_path:hsa04350", "kegg_path:hsa04390", "kegg_path:hsa04550", "kegg_path:hsa04919", "kegg_path:hsa05200", "kegg_path:hsa05217", "kegg_path:hsa05418" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P12644", "ensembl_id": "None", "entrez_id": "ENSG00000125378", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.362577" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "864" }, { "type": "SmallVariant", "id": "1383" }, { "type": "SmallVariant", "id": "2165" }, { "type": "SmallVariant", "id": "2775" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BMP4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BMP4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "269" }, { "type": "GeneCombination", "id": "436" }, { "type": "GeneCombination", "id": "737" }, { "type": "GeneCombination", "id": "928" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BMP4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BMP4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/BMP4/?format=api" } }, { "type": "Gene", "id": "E2F4", "attributes": { "go_molecular_function": [ "protein dimerization activity", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "promoter-specific chromatin binding", "DNA-binding transcription factor activity", "DNA binding" ], "pathway_id": [ "R-HSA-1362300", "R-HSA-6804114", "kegg_path:hsa04110", "R-HSA-453279", "R-HSA-69656", "kegg_path:hsa04350", "R-HSA-69278", "R-HSA-69202", "R-HSA-69231", "R-HSA-69242", "R-HSA-73857", "R-HSA-1362277", "R-HSA-2173793", "kegg_path:hsa04218", "R-HSA-212436", "R-HSA-3700989", "R-HSA-6791312", "R-HSA-1640170", "R-HSA-170834", "R-HSA-2173796", "R-HSA-74160", "R-HSA-69205", "R-HSA-1538133", "R-HSA-9006936", "R-HSA-69236", "R-HSA-162582", "R-HSA-69206" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q16254", "ensembl_id": "ENSG00000205250", "entrez_id": "1874", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.510478" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "867" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/E2F4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/E2F4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "269" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/E2F4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/E2F4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/E2F4/?format=api" } }, { "type": "Gene", "id": "SMAD4", "attributes": { "go_molecular_function": [ "transcription coactivator binding", "protein homodimerization activity", "I-SMAD binding", "filamin binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "collagen binding", "protein binding", "identical protein binding", "chromatin binding", "sulfate binding", "RNA polymerase II-specific DNA-binding transcription factor binding", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "transcription cis-regulatory region binding", "DNA binding", "metal ion binding", "R-SMAD binding", "DNA-binding transcription factor activity", "sequence-specific DNA binding" ], "pathway_id": [ "kegg_path:hsa04390", "kegg_path:hsa04933", "kegg_path:hsa05220", "R-HSA-2173793", "kegg_path:hsa05212", "R-HSA-8941855", "R-HSA-170834", "kegg_path:hsa04110", "kegg_path:hsa05161", "R-HSA-452723", "kegg_path:hsa05161", "kegg_path:hsa04110", "R-HSA-1643685", "kegg_path:hsa05212", "R-HSA-2173795", "R-HSA-8952158", "kegg_path:hsa05220", "kegg_path:hsa04390", "kegg_path:hsa04933", "R-HSA-201451", "kegg_path:hsa05166", "R-HSA-3315487", "R-HSA-5689880", "R-HSA-1266738", "kegg_path:hsa05200", "R-HSA-9615017", "kegg_path:hsa04371", "kegg_path:hsa04371", "R-HSA-5663202", "R-HSA-74160", "R-HSA-8878166", "kegg_path:hsa05200", "R-HSA-9006936", "kegg_path:hsa05166", "R-HSA-1502540", "R-HSA-162582", "R-HSA-3304347", "kegg_path:hsa04350", "kegg_path:hsa05226", "R-HSA-73857", "R-HSA-5688426", "kegg_path:hsa04068", "kegg_path:hsa05225", "kegg_path:hsa04520", "kegg_path:hsa04659", "R-HSA-392499", "R-HSA-9614085", "kegg_path:hsa04659", "kegg_path:hsa04520", "kegg_path:hsa04068", "kegg_path:hsa05225", "R-HSA-9617828", "R-HSA-3304351", "R-HSA-3311021", "kegg_path:hsa04350", "kegg_path:hsa05226", "R-HSA-1181150", "kegg_path:hsa04310", "kegg_path:hsa04550", "R-HSA-212436", "R-HSA-2173796", "kegg_path:hsa05210", "kegg_path:hsa05210", "R-HSA-3304349", "R-HSA-8941326", "R-HSA-2173789", "R-HSA-597592", "kegg_path:hsa04550", "R-HSA-8878159", "kegg_path:hsa04310" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13485", "ensembl_id": "ENSG00000141646", "entrez_id": "4089", "chromosome_number": "18", "lastmodified": "2021-10-18T11:00:44.651786" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "866" }, { "type": "SmallVariant", "id": "2465" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMAD4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMAD4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "269" }, { "type": "GeneCombination", "id": "833" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMAD4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMAD4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SMAD4/?format=api" } }, { "type": "Gene", "id": "TSHZ1", "attributes": { "go_molecular_function": [ "metal ion binding", "DNA binding", "DNA-binding transcription factor activity, RNA polymerase II-specific" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q6ZSZ6", "ensembl_id": "ENSG00000179981", "entrez_id": "10194", "chromosome_number": "18", "lastmodified": "2021-10-18T11:00:44.842688" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "868" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TSHZ1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TSHZ1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "269" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TSHZ1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TSHZ1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TSHZ1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }