Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/761/genes/?format=api
{ "data": [ { "type": "Gene", "id": "MCM9", "attributes": { "go_molecular_function": [ "DNA helicase activity", "single-stranded DNA binding", "MutSalpha complex binding", "protein binding", "ATP hydrolysis activity", "enzyme binding", "MutLbeta complex binding", "MutSbeta complex binding", "chromatin binding", "single-stranded DNA helicase activity", "ATP binding", "protein-containing complex binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NXL9", "ensembl_id": "ENSG00000111877", "entrez_id": "254394", "chromosome_number": "6", "lastmodified": "2021-10-18T11:00:44.520256" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1159" }, { "type": "SmallVariant", "id": "2260" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MCM9/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MCM9/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "371" }, { "type": "GeneCombination", "id": "761" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MCM9/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MCM9/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MCM9/?format=api" } }, { "type": "Gene", "id": "NCOR2", "attributes": { "go_molecular_function": [ "Notch binding", "protein binding", "DNA binding", "glucocorticoid receptor binding", "protein N-terminus binding", "transcription corepressor activity", "histone deacetylase binding", "chromatin binding", "retinoid X receptor binding", "protein-containing complex binding" ], "pathway_id": [ "R-HSA-2644603", "R-HSA-2894858", "R-HSA-157118", "R-HSA-9697154", "R-HSA-2173793", "R-HSA-9029569", "R-HSA-170834", "kegg_path:hsa05169", "R-HSA-1643685", "R-HSA-2173795", "R-HSA-9675151", "R-HSA-3247509", "R-HSA-9022692", "R-HSA-1266738", "R-HSA-3214815", "R-HSA-400206", "R-HSA-212436", "R-HSA-5663205", "R-HSA-9006931", "R-HSA-2122947", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-556833", "R-HSA-9024446", "R-HSA-9005891", "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "R-HSA-9022537", "R-HSA-9609690", "R-HSA-597592", "R-HSA-9006936", "kegg_path:hsa04330", "R-HSA-4839726", "R-HSA-162582", "R-HSA-1980143", "R-HSA-9609646", "R-HSA-383280", "R-HSA-1430728", "R-HSA-73857", "R-HSA-8986944", "R-HSA-1989781", "R-HSA-9623433", "R-HSA-2894862", "R-HSA-9005895", "R-HSA-3899300", "R-HSA-381340", "R-HSA-392499", "R-HSA-2644602", "R-HSA-2644606" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9Y618", "ensembl_id": "ENSG00000196498", "entrez_id": "9612", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:58.085323" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "2122" }, { "type": "SmallVariant", "id": "2258" }, { "type": "SmallVariant", "id": "2270" }, { "type": "SmallVariant", "id": "2295" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NCOR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NCOR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "731" }, { "type": "GeneCombination", "id": "761" }, { "type": "GeneCombination", "id": "763" }, { "type": "GeneCombination", "id": "770" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NCOR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NCOR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NCOR2/?format=api" } }, { "type": "Gene", "id": "RAD52", "attributes": { "go_molecular_function": [ "single-stranded DNA binding", "identical protein binding", "DNA binding", "protein binding" ], "pathway_id": [ "kegg_path:hsa03440", "R-HSA-2990846", "R-HSA-3108232", "kegg_path:hsa03440", "R-HSA-5693567", "R-HSA-5693538", "R-HSA-73894", "R-HSA-5685938", "R-HSA-5693532", "R-HSA-3108214", "R-HSA-392499", "R-HSA-597592" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P43351", "ensembl_id": "ENSG00000002016", "entrez_id": "5893", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:59.103162" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2259" }, { "type": "SmallVariant", "id": "2285" }, { "type": "SmallVariant", "id": "2310" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RAD52/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RAD52/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "761" }, { "type": "GeneCombination", "id": "767" }, { "type": "GeneCombination", "id": "776" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RAD52/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RAD52/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RAD52/?format=api" } }, { "type": "Gene", "id": "RAD54L", "attributes": { "go_molecular_function": [ "DNA helicase activity", "protein binding", "ATP hydrolysis activity", "DNA translocase activity", "metal ion binding", "ATP-dependent DNA/DNA annealing activity", "ATP binding" ], "pathway_id": [ "kegg_path:hsa03440" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q92698", "ensembl_id": "ENSG00000085999", "entrez_id": "8438", "chromosome_number": "1", "lastmodified": "2022-08-04T14:14:59.053107" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2261" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RAD54L/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RAD54L/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "761" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RAD54L/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RAD54L/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RAD54L/?format=api" } }, { "type": "Gene", "id": "RYR3", "attributes": { "go_molecular_function": [ "['calcium-induced calcium release activity', 'calcium ion binding', 'ryanodine-sensitive calcium-release channel activity', 'calcium-release channel activity', 'calmodulin binding']" ], "pathway_id": [ "kegg_path:hsa04020", "kegg_path:hsa04371", "kegg_path:hsa04713", "kegg_path:hsa04921", "kegg_path:hsa04970", "kegg_path:hsa05010", "kegg_path:hsa05012", "kegg_path:hsa05020", "kegg_path:hsa05022", "R-HSA-2672351", "R-HSA-382551", "R-HSA-397014", "R-HSA-5576891", "R-HSA-5578775", "R-HSA-983712" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "A0A0X1KG73", "ensembl_id": "None", "entrez_id": "ENSG00000198838", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.558256" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1733" }, { "type": "SmallVariant", "id": "2257" }, { "type": "SmallVariant", "id": "2265" }, { "type": "SmallVariant", "id": "3071" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RYR3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RYR3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "571" }, { "type": "GeneCombination", "id": "761" }, { "type": "GeneCombination", "id": "762" }, { "type": "GeneCombination", "id": "1030" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RYR3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RYR3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RYR3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }