Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/545/genes/?format=api
{ "data": [ { "type": "Gene", "id": "COBL", "attributes": { "go_molecular_function": [ "actin monomer binding", "actin binding", "protein binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O75128", "ensembl_id": "ENSG00000106078", "entrez_id": "23242", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.994636" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1554" }, { "type": "SmallVariant", "id": "1604" }, { "type": "SmallVariant", "id": "1659" }, { "type": "SmallVariant", "id": "1674" }, { "type": "SmallVariant", "id": "1681" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COBL/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COBL/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "499" }, { "type": "GeneCombination", "id": "515" }, { "type": "GeneCombination", "id": "539" }, { "type": "GeneCombination", "id": "545" }, { "type": "GeneCombination", "id": "547" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COBL/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COBL/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COBL/?format=api" } }, { "type": "Gene", "id": "NOG", "attributes": { "go_molecular_function": [ "protein binding" ], "pathway_id": [ "R-HSA-201451", "R-HSA-9006936", "kegg_path:hsa04350", "R-HSA-162582" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13253", "ensembl_id": "ENSG00000183691", "entrez_id": "9241", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.248132" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1565" }, { "type": "SmallVariant", "id": "1651" }, { "type": "SmallVariant", "id": "1672" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOG/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOG/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "503" }, { "type": "GeneCombination", "id": "536" }, { "type": "GeneCombination", "id": "545" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOG/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOG/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOG/?format=api" } }, { "type": "Gene", "id": "ZNRF3", "attributes": { "go_molecular_function": [ "['ubiquitin-protein transferase activity', 'frizzled binding', 'protein binding', 'metal ion binding', 'ubiquitin protein ligase activity']" ], "pathway_id": [ "kegg_path:hsa04310", "R-HSA-162582", "R-HSA-195721", "R-HSA-201681", "R-HSA-4641263" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9ULT6", "ensembl_id": "None", "entrez_id": "ENSG00000183579", "chromosome_number": "22", "lastmodified": "2021-10-18T11:00:44.653587" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "1541" }, { "type": "SmallVariant", "id": "1555" }, { "type": "SmallVariant", "id": "1642" }, { "type": "SmallVariant", "id": "1673" }, { "type": "SmallVariant", "id": "3203" }, { "type": "SmallVariant", "id": "3235" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZNRF3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZNRF3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "494" }, { "type": "GeneCombination", "id": "500" }, { "type": "GeneCombination", "id": "533" }, { "type": "GeneCombination", "id": "545" }, { "type": "GeneCombination", "id": "1070" }, { "type": "GeneCombination", "id": "1075" }, { "type": "GeneCombination", "id": "1083" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZNRF3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZNRF3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZNRF3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }