Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/620/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ANOS1", "attributes": { "go_molecular_function": [ "['heparin binding', 'extracellular matrix structural constituent', 'serine-type endopeptidase inhibitor activity', 'protein binding']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-190236", "R-HSA-190242", "R-HSA-190373", "R-HSA-5654726", "R-HSA-5654736", "R-HSA-9006934" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P23352", "ensembl_id": "None", "entrez_id": "ENSG00000011201", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.754255" }, "relationships": { "variant_set": { "meta": { "count": 36 }, "data": [ { "type": "CopyNumberVariant", "id": "3399" }, { "type": "CopyNumberVariant", "id": "1795" }, { "type": "CopyNumberVariant", "id": "1867" }, { "type": "SmallVariant", "id": "245" }, { "type": "SmallVariant", "id": "309" }, { "type": "SmallVariant", "id": "399" }, { "type": "SmallVariant", "id": "559" }, { "type": "SmallVariant", "id": "777" }, { "type": "SmallVariant", "id": "849" }, { "type": "SmallVariant", "id": "855" }, { "type": "SmallVariant", "id": "973" }, { "type": "SmallVariant", "id": "975" }, { "type": "SmallVariant", "id": "1083" }, { "type": "SmallVariant", "id": "1832" }, { "type": "SmallVariant", "id": "1833" }, { "type": "SmallVariant", "id": "1863" }, { "type": "SmallVariant", "id": "1876" }, { "type": "SmallVariant", "id": "1927" }, { "type": "SmallVariant", "id": "2202" }, { "type": "SmallVariant", "id": "2395" }, { "type": "SmallVariant", "id": "2405" }, { "type": "SmallVariant", "id": "2710" }, { "type": "SmallVariant", "id": "2727" }, { "type": "SmallVariant", "id": "2731" }, { "type": "SmallVariant", "id": "2767" }, { "type": "SmallVariant", "id": "2827" }, { "type": "SmallVariant", "id": "2916" }, { "type": "SmallVariant", "id": "2947" }, { "type": "SmallVariant", "id": "2957" }, { "type": "SmallVariant", "id": "2962" }, { "type": "SmallVariant", "id": "2966" }, { "type": "SmallVariant", "id": "2987" }, { "type": "SmallVariant", "id": "2988" }, { "type": "SmallVariant", "id": "2993" }, { "type": "SmallVariant", "id": "2997" }, { "type": "SmallVariant", "id": "3158" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ANOS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ANOS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 29 }, "data": [ { "type": "GeneCombination", "id": "191" }, { "type": "GeneCombination", "id": "264" }, { "type": "GeneCombination", "id": "261" }, { "type": "GeneCombination", "id": "354" }, { "type": "GeneCombination", "id": "594" }, { "type": "GeneCombination", "id": "620" }, { "type": "GeneCombination", "id": "623" }, { "type": "GeneCombination", "id": "624" }, { "type": "GeneCombination", "id": "642" }, { "type": "GeneCombination", "id": "651" }, { "type": "GeneCombination", "id": "901" }, { "type": "GeneCombination", "id": "907" }, { "type": "GeneCombination", "id": "312" }, { "type": "GeneCombination", "id": "90" }, { "type": "GeneCombination", "id": "243" }, { "type": "GeneCombination", "id": "968" }, { "type": "GeneCombination", "id": "969" }, { "type": "GeneCombination", "id": "975" }, { "type": "GeneCombination", "id": "981" }, { "type": "GeneCombination", "id": "984" }, { "type": "GeneCombination", "id": "986" }, { "type": "GeneCombination", "id": "988" }, { "type": "GeneCombination", "id": "992" }, { "type": "GeneCombination", "id": "997" }, { "type": "GeneCombination", "id": "998" }, { "type": "GeneCombination", "id": "1000" }, { "type": "GeneCombination", "id": "1001" }, { "type": "GeneCombination", "id": "1054" }, { "type": "GeneCombination", "id": "1088" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ANOS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ANOS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ANOS1/?format=api" } }, { "type": "Gene", "id": "NOS1", "attributes": { "go_molecular_function": [ "calcium-dependent protein binding", "FMN binding", "nitric-oxide synthase activity", "flavin adenine dinucleotide binding", "calmodulin binding", "oxidoreductase activity" ], "pathway_id": [ "kegg_path:hsa01100", "kegg_path:hsa04730", "kegg_path:hsa00330", "kegg_path:hsa04713", "kegg_path:hsa04970", "R-HSA-5578775", "kegg_path:hsa00220", "kegg_path:hsa04926", "kegg_path:hsa05014", "kegg_path:hsa04713", "kegg_path:hsa04970", "kegg_path:hsa00330", "kegg_path:hsa01100", "kegg_path:hsa04730", "kegg_path:hsa00220", "kegg_path:hsa05022", "kegg_path:hsa04371", "kegg_path:hsa04145", "kegg_path:hsa05010", "kegg_path:hsa04926", "kegg_path:hsa05014", "R-HSA-109582", "R-HSA-397014", "R-HSA-1222556", "kegg_path:hsa04020", "kegg_path:hsa01100", "kegg_path:hsa04730", "R-HSA-168249", "kegg_path:hsa04020", "kegg_path:hsa00330", "kegg_path:hsa04713", "kegg_path:hsa04970", "kegg_path:hsa04926", "kegg_path:hsa05014", "R-HSA-168256", "kegg_path:hsa04371", "kegg_path:hsa05022", "kegg_path:hsa00220", "R-HSA-5576891", "kegg_path:hsa05010", "kegg_path:hsa04145", "kegg_path:hsa04371", "R-HSA-392154", "R-HSA-418346", "kegg_path:hsa05022", "kegg_path:hsa04145", "kegg_path:hsa05010", "kegg_path:hsa04020" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P29475", "ensembl_id": "ENSG00000089250", "entrez_id": "4842", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.332724" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "907" }, { "type": "SmallVariant", "id": "1666" }, { "type": "SmallVariant", "id": "1866" }, { "type": "SmallVariant", "id": "1925" }, { "type": "SmallVariant", "id": "1947" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "283" }, { "type": "GeneCombination", "id": "542" }, { "type": "GeneCombination", "id": "620" }, { "type": "GeneCombination", "id": "650" }, { "type": "GeneCombination", "id": "660" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOS1/?format=api" } }, { "type": "Gene", "id": "STS", "attributes": { "go_molecular_function": [ "sulfuric ester hydrolase activity", "steryl-sulfatase activity", "hydrolase activity", "catalytic activity", "arylsulfatase activity", "metal ion binding" ], "pathway_id": [ "R-HSA-392499", "R-HSA-163841", "R-HSA-597592", "R-HSA-1663150", "R-HSA-1430728", "R-HSA-1660662", "R-HSA-428157", "kegg_path:hsa00140", "R-HSA-556833" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P08842", "ensembl_id": "ENSG00000101846", "entrez_id": "412", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.760452" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "CopyNumberVariant", "id": "1868" }, { "type": "SmallVariant", "id": "1961" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/STS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/STS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "620" }, { "type": "GeneCombination", "id": "670" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/STS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/STS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/STS/?format=api" } }, { "type": "Gene", "id": "TACR3", "attributes": { "go_molecular_function": [ "['tachykinin receptor activity', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa04020", "kegg_path:hsa04080", "R-HSA-162582", "R-HSA-372790", "R-HSA-373076", "R-HSA-375276", "R-HSA-380095", "R-HSA-388396", "R-HSA-416476", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P29371", "ensembl_id": "None", "entrez_id": "ENSG00000169836", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.399598" }, "relationships": { "variant_set": { "meta": { "count": 12 }, "data": [ { "type": "SmallVariant", "id": "2694" }, { "type": "SmallVariant", "id": "819" }, { "type": "SmallVariant", "id": "851" }, { "type": "SmallVariant", "id": "852" }, { "type": "SmallVariant", "id": "1085" }, { "type": "SmallVariant", "id": "1865" }, { "type": "SmallVariant", "id": "2693" }, { "type": "SmallVariant", "id": "2701" }, { "type": "SmallVariant", "id": "2703" }, { "type": "SmallVariant", "id": "2712" }, { "type": "SmallVariant", "id": "2714" }, { "type": "SmallVariant", "id": "2929" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TACR3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TACR3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 10 }, "data": [ { "type": "GeneCombination", "id": "262" }, { "type": "GeneCombination", "id": "264" }, { "type": "GeneCombination", "id": "258" }, { "type": "GeneCombination", "id": "355" }, { "type": "GeneCombination", "id": "620" }, { "type": "GeneCombination", "id": "896" }, { "type": "GeneCombination", "id": "897" }, { "type": "GeneCombination", "id": "899" }, { "type": "GeneCombination", "id": "973" }, { "type": "GeneCombination", "id": "1133" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TACR3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TACR3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TACR3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }