Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/518/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ALX1", "attributes": { "go_molecular_function": [ "protein binding", "DNA binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "sequence-specific double-stranded DNA binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15699", "ensembl_id": "ENSG00000180318", "entrez_id": "8092", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.526993" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1561" }, { "type": "SmallVariant", "id": "1576" }, { "type": "SmallVariant", "id": "1610" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALX1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALX1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "502" }, { "type": "GeneCombination", "id": "507" }, { "type": "GeneCombination", "id": "518" }, { "type": "GeneCombination", "id": "533" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALX1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALX1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ALX1/?format=api" } }, { "type": "Gene", "id": "BRD2", "attributes": { "go_molecular_function": [ "protein serine/threonine kinase activity", "lysine-acetylated histone binding", "protein binding", "chromatin binding" ], "pathway_id": [ "R-HSA-8878159", "R-HSA-73857", "R-HSA-212436", "R-HSA-74160", "R-HSA-8951936", "R-HSA-8878159", "R-HSA-74160", "R-HSA-8878159", "R-HSA-74160", "R-HSA-8951936", "R-HSA-73857", "R-HSA-212436", "R-HSA-212436", "R-HSA-8878159", "R-HSA-8951936", "R-HSA-73857", "R-HSA-73857", "R-HSA-8951936", "R-HSA-212436", "R-HSA-74160" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P25440", "ensembl_id": "ENSG00000204256", "entrez_id": "6046", "chromosome_number": "6", "lastmodified": "2021-10-18T11:00:44.843602" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1614" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BRD2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BRD2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "518" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BRD2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BRD2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/BRD2/?format=api" } }, { "type": "Gene", "id": "CELSR3", "attributes": { "go_molecular_function": [ "['G protein-coupled receptor activity', 'calcium ion binding', 'protein binding']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NYQ7", "ensembl_id": "None", "entrez_id": "ENSG00000008300", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.329047" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1528" }, { "type": "SmallVariant", "id": "1566" }, { "type": "SmallVariant", "id": "1611" }, { "type": "SmallVariant", "id": "1612" }, { "type": "SmallVariant", "id": "3115" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "490" }, { "type": "GeneCombination", "id": "503" }, { "type": "GeneCombination", "id": "518" }, { "type": "GeneCombination", "id": "526" }, { "type": "GeneCombination", "id": "1043" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR3/?format=api" } }, { "type": "Gene", "id": "CUBN", "attributes": { "go_molecular_function": [ "signaling receptor activity", "cobalamin binding", "cargo receptor activity", "calcium ion binding", "metal ion binding" ], "pathway_id": [ "R-HSA-174824", "R-HSA-382551", "R-HSA-1430728", "R-HSA-3359462", "R-HSA-556833", "R-HSA-3359463", "R-HSA-3296482", "R-HSA-1643685", "R-HSA-196849", "kegg_path:hsa04977", "R-HSA-196854", "R-HSA-8964011", "R-HSA-196741", "R-HSA-3296469", "R-HSA-5668914", "R-HSA-8957322", "R-HSA-8964043", "R-HSA-196791" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O60494", "ensembl_id": "ENSG00000107611", "entrez_id": "8029", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.733343" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "1516" }, { "type": "SmallVariant", "id": "1524" }, { "type": "SmallVariant", "id": "1563" }, { "type": "SmallVariant", "id": "1601" }, { "type": "SmallVariant", "id": "1609" }, { "type": "SmallVariant", "id": "1677" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CUBN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CUBN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "487" }, { "type": "GeneCombination", "id": "489" }, { "type": "GeneCombination", "id": "503" }, { "type": "GeneCombination", "id": "515" }, { "type": "GeneCombination", "id": "518" }, { "type": "GeneCombination", "id": "547" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CUBN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CUBN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CUBN/?format=api" } }, { "type": "Gene", "id": "SHROOM3", "attributes": { "go_molecular_function": [ "actin filament binding", "actin binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8TF72", "ensembl_id": "ENSG00000138771", "entrez_id": "57619", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.265166" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1521" }, { "type": "SmallVariant", "id": "1613" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHROOM3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "488" }, { "type": "GeneCombination", "id": "518" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHROOM3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }