Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/777/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ATG4C", "attributes": { "go_molecular_function": [ "cysteine-type peptidase activity", "protein binding", "cysteine-type endopeptidase activity" ], "pathway_id": [ "R-HSA-9612973", "R-HSA-1632852", "kegg_path:hsa04136", "kegg_path:hsa04140" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q96DT6", "ensembl_id": "ENSG00000125703", "entrez_id": "84938", "chromosome_number": "1", "lastmodified": "2022-08-04T14:15:00.000411" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2275" }, { "type": "SmallVariant", "id": "2312" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATG4C/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATG4C/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "765" }, { "type": "GeneCombination", "id": "777" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATG4C/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATG4C/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ATG4C/?format=api" } }, { "type": "Gene", "id": "ATM", "attributes": { "go_molecular_function": [ "DNA-dependent protein kinase activity", "protein binding", "identical protein binding", "protein serine/threonine kinase activity", "DNA binding", "1-phosphatidylinositol-3-kinase activity", "protein serine/threonine/tyrosine kinase activity", "protein N-terminus binding", "ATP binding", "protein serine kinase activity", "protein-containing complex binding" ], "pathway_id": [ "kegg_path:hsa04210", "R-HSA-2559583", "kegg_path:hsa05202", "kegg_path:hsa05206", "R-HSA-1474165", "kegg_path:hsa01524", "R-HSA-5693565", "R-HSA-5693568", "kegg_path:hsa04064", "kegg_path:hsa04068", "R-HSA-5693537", "kegg_path:hsa05170", "R-HSA-73857", "R-HSA-69580", "kegg_path:hsa05165", "R-HSA-5693616", "R-HSA-9663891", "R-HSA-5685938", "R-HSA-912446", "kegg_path:hsa04115", "R-HSA-6803204", "R-HSA-6803207", "R-HSA-3371556", "R-HSA-5693606", "R-HSA-212436", "R-HSA-1640170", "R-HSA-3371453", "kegg_path:hsa04115", "R-HSA-5693548", "R-HSA-349425", "R-HSA-5693607", "kegg_path:hsa05165", "R-HSA-5633007", "R-HSA-5693554", "R-HSA-6804757", "R-HSA-69615", "R-HSA-6804756", "R-HSA-73894", "R-HSA-6806003", "kegg_path:hsa04110", "R-HSA-5693571", "R-HSA-6804760", "R-HSA-69541", "R-HSA-9664873", "kegg_path:hsa04110", "R-HSA-2559586", "R-HSA-5693538", "R-HSA-69563", "kegg_path:hsa05166", "R-HSA-8953897", "R-HSA-1500620", "R-HSA-5633008", "R-HSA-5693532", "R-HSA-6796648", "R-HSA-74160", "kegg_path:hsa04218", "kegg_path:hsa03440", "kegg_path:hsa05131", "R-HSA-2262752", "kegg_path:hsa04218", "R-HSA-3700989", "R-HSA-5685942", "kegg_path:hsa05131", "kegg_path:hsa03440", "R-HSA-1632852", "R-HSA-69481", "kegg_path:hsa05166", "R-HSA-9612973", "R-HSA-5693579", "kegg_path:hsa05170", "R-HSA-69473", "kegg_path:hsa04064", "kegg_path:hsa04068", "kegg_path:hsa05206", "R-HSA-69620", "kegg_path:hsa01524", "R-HSA-5693567", "kegg_path:hsa05202", "kegg_path:hsa04210" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q13315", "ensembl_id": "ENSG00000149311", "entrez_id": "472", "chromosome_number": "11", "lastmodified": "2022-08-04T14:14:58.235652" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2253" }, { "type": "SmallVariant", "id": "2294" }, { "type": "SmallVariant", "id": "2313" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATM/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATM/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "760" }, { "type": "GeneCombination", "id": "770" }, { "type": "GeneCombination", "id": "777" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATM/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATM/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ATM/?format=api" } }, { "type": "Gene", "id": "PRIM1", "attributes": { "go_molecular_function": [ "protein binding", "ribonucleotide binding", "magnesium ion binding", "DNA primase activity", "zinc ion binding" ], "pathway_id": [ "R-HSA-453279", "R-HSA-157579", "R-HSA-69278", "R-HSA-69242", "R-HSA-174417", "R-HSA-68952", "R-HSA-69091", "R-HSA-69239", "R-HSA-174430", "R-HSA-69183", "kegg_path:hsa03030", "R-HSA-113501", "R-HSA-1640170", "R-HSA-69190", "R-HSA-69306", "R-HSA-174411", "R-HSA-180786", "R-HSA-69002", "R-HSA-69166", "R-HSA-69186", "R-HSA-68962", "R-HSA-69206", "R-HSA-113510", "R-HSA-69109", "R-HSA-73886" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P49642", "ensembl_id": "ENSG00000198056", "entrez_id": "5557", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:57.433424" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2314" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PRIM1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PRIM1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "777" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PRIM1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PRIM1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PRIM1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }