Gene Combination Instance
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genecombinations/380/?format=api
{ "data": { "type": "GeneCombination", "id": "380", "attributes": { "gene_relationship": [ "Directly interacting", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(PTPN11, SOS1)" ], "common_pathways": [ "MAPK family signaling cascades", "Downstream signaling of activated FGFR3", "Signaling by FLT3 ITD and TKD mutants", "signaling and aggregation", "Proteoglycans in cancer", "Chronic myeloid leukemia", "Downstream signaling of activated FGFR4", "Axon guidance", "Hemostasis", "Signaling by Receptor Tyrosine Kinases", "Signaling by FGFR", "Insulin receptor signalling cascade", "FRS-mediated FGFR1 signaling", "IRS-related events triggered by IGF1R", "Cell surface interactions at the vascular wall", "Ras signaling pathway", "Downstream signaling of activated FGFR1", "Signaling by PDGF", "Signaling by EGFR", "Interleukin-3", "RET signaling", "JAK-STAT signaling pathway", "IGF1R signaling cascade", "Signaling by FGFR2", "Interleukin-5 and GM-CSF signaling", "Developmental Biology", "Renal cell carcinoma", "Downstream signal transduction", "Signaling by NTRK2 (TRKB)", "Signaling by SCF-KIT", "Platelet activation", "MAPK1/MAPK3 signaling", "Activated NTRK2 signals through FRS2 and FRS3", "Nervous system development", "Signaling by FGFR3", "Natural killer cell mediated cytotoxicity", "Immune System", "Signaling by FGFR1", "Phospholipase D signaling pathway", "Adaptive Immune System", "Neurotrophin signaling pathway", "FRS-mediated FGFR3 signaling", "Cytokine Signaling in Immune system", "Innate Immune System", "FRS-mediated FGFR4 signaling", "FLT3 signaling in disease", "Signaling by Interleukins", "Disease", "Signaling by MET", "Signaling by FGFR4", "Tie2 Signaling", "Downstream signaling of activated FGFR2", "Diseases of signal transduction by growth factor receptors and second messengers", "FLT3 Signaling", "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "Signaling by Insulin receptor", "IRS-mediated signalling", "FRS-mediated FGFR2 signaling", "Signal Transduction", "Signaling by NTRKs" ], "genecomb_metascore": 2, "lastmodified": "2021-10-18T11:01:05.430286" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI568" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/380/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/380/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "PTPN11" }, { "type": "Gene", "id": "SOS1" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/380/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/380/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/380/?format=api" } } }