Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/522/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ARID1A", "attributes": { "go_molecular_function": [ "nuclear receptor binding", "protein binding", "transcription coactivator activity", "DNA binding" ], "pathway_id": [ "R-HSA-8878171", "R-HSA-4839726", "kegg_path:hsa05225", "R-HSA-74160", "kegg_path:hsa04714", "R-HSA-3214858", "R-HSA-212436", "R-HSA-3247509", "R-HSA-73857", "R-HSA-8939243" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O14497", "ensembl_id": "ENSG00000117713", "entrez_id": "8289", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.737431" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1530" }, { "type": "SmallVariant", "id": "1584" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ARID1A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ARID1A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "491" }, { "type": "GeneCombination", "id": "510" }, { "type": "GeneCombination", "id": "522" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ARID1A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ARID1A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ARID1A/?format=api" } }, { "type": "Gene", "id": "NKX2-8", "attributes": { "go_molecular_function": [ "DNA-binding transcription activator activity, RNA polymerase II-specific", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "sequence-specific double-stranded DNA binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "sequence-specific DNA binding", "DNA binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O15522", "ensembl_id": "ENSG00000136327", "entrez_id": "26257", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.668422" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1620" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NKX2-8/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NKX2-8/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "522" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NKX2-8/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NKX2-8/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NKX2-8/?format=api" } }, { "type": "Gene", "id": "PCYT1A", "attributes": { "go_molecular_function": [ "transferase activity", "phosphatidylcholine binding", "catalytic activity", "nucleotidyltransferase activity", "choline-phosphate cytidylyltransferase activity" ], "pathway_id": [ "R-HSA-1483257", "kegg_path:hsa05231", "kegg_path:hsa00564", "kegg_path:hsa01100", "R-HSA-556833", "kegg_path:hsa00440", "R-HSA-1483206", "R-HSA-1430728", "R-HSA-1483191" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P49585", "ensembl_id": "ENSG00000161217", "entrez_id": "5130", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.439275" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1509" }, { "type": "SmallVariant", "id": "1621" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PCYT1A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PCYT1A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "485" }, { "type": "GeneCombination", "id": "522" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PCYT1A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PCYT1A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PCYT1A/?format=api" } }, { "type": "Gene", "id": "SETD2", "attributes": { "go_molecular_function": [ "protein binding", "histone methyltransferase activity (H3-K36 specific)", "protein-lysine N-methyltransferase activity", "alpha-tubulin binding", "histone-lysine N-methyltransferase activity" ], "pathway_id": [ "R-HSA-4839726", "R-HSA-3214841", "kegg_path:hsa01100", "kegg_path:hsa00310", "R-HSA-3247509" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9BYW2", "ensembl_id": "ENSG00000181555", "entrez_id": "29072", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.783115" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1661" }, { "type": "SmallVariant", "id": "1547" }, { "type": "SmallVariant", "id": "1622" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SETD2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SETD2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "496" }, { "type": "GeneCombination", "id": "522" }, { "type": "GeneCombination", "id": "540" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SETD2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SETD2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SETD2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }