Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/492/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ALDH1L1", "attributes": { "go_molecular_function": [ "hydroxymethyl-, formyl- and related transferase activity", "protein binding", "catalytic activity", "formyltetrahydrofolate dehydrogenase activity", "aldehyde dehydrogenase (NAD+) activity", "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor", "oxidoreductase activity" ], "pathway_id": [ "R-HSA-196849", "R-HSA-196854", "R-HSA-196757", "kegg_path:hsa00670", "R-HSA-1430728" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O75891", "ensembl_id": "ENSG00000144908", "entrez_id": "10840", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.811028" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1496" }, { "type": "SmallVariant", "id": "1505" }, { "type": "SmallVariant", "id": "1508" }, { "type": "SmallVariant", "id": "1534" }, { "type": "SmallVariant", "id": "1638" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALDH1L1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALDH1L1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "479" }, { "type": "GeneCombination", "id": "483" }, { "type": "GeneCombination", "id": "485" }, { "type": "GeneCombination", "id": "492" }, { "type": "GeneCombination", "id": "530" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALDH1L1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALDH1L1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ALDH1L1/?format=api" } }, { "type": "Gene", "id": "FTCD", "attributes": { "go_molecular_function": [ "protein binding", "transferase activity", "microtubule binding", "folic acid binding", "catalytic activity", "lyase activity", "formimidoyltetrahydrofolate cyclodeaminase activity", "glutamate formimidoyltransferase activity" ], "pathway_id": [ "R-HSA-1430728", "R-HSA-71291", "kegg_path:hsa01100", "R-HSA-70921", "kegg_path:hsa00340", "kegg_path:hsa00670" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O95954", "ensembl_id": "ENSG00000160282", "entrez_id": "10841", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.283350" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1533" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FTCD/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FTCD/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "492" }, { "type": "GeneCombination", "id": "513" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FTCD/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FTCD/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FTCD/?format=api" } }, { "type": "Gene", "id": "SALL2", "attributes": { "go_molecular_function": [ "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "protein binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "DNA binding", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "metal ion binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9Y467", "ensembl_id": "ENSG00000165821", "entrez_id": "6297", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.473370" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1532" }, { "type": "SmallVariant", "id": "1590" }, { "type": "SmallVariant", "id": "1653" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SALL2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SALL2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "492" }, { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "521" }, { "type": "GeneCombination", "id": "537" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SALL2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SALL2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SALL2/?format=api" } }, { "type": "Gene", "id": "SCRIB", "attributes": { "go_molecular_function": [], "pathway_id": [ "kegg_path:hsa05203", "R-HSA-4086400", "kegg_path:hsa04390", "kegg_path:hsa05165", "R-HSA-3858494", "kegg_path:hsa04530", "R-HSA-4608870", "kegg_path:hsa05165", "kegg_path:hsa04390", "kegg_path:hsa04390", "kegg_path:hsa05165", "kegg_path:hsa05203", "kegg_path:hsa04530", "R-HSA-195721", "R-HSA-162582", "kegg_path:hsa04530", "R-HSA-195721", "R-HSA-162582", "kegg_path:hsa05165", "kegg_path:hsa04390", "kegg_path:hsa05203", "R-HSA-4086400", "kegg_path:hsa04530", "R-HSA-4608870", "R-HSA-3858494", "kegg_path:hsa05203" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q14160", "ensembl_id": "ENSG00000180900", "entrez_id": "23513", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.361258" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "1074" }, { "type": "SmallVariant", "id": "1076" }, { "type": "SmallVariant", "id": "1078" }, { "type": "SmallVariant", "id": "1082" }, { "type": "SmallVariant", "id": "1535" }, { "type": "SmallVariant", "id": "1588" }, { "type": "SmallVariant", "id": "1592" }, { "type": "SmallVariant", "id": "1616" }, { "type": "SmallVariant", "id": "1682" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SCRIB/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SCRIB/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "351" }, { "type": "GeneCombination", "id": "353" }, { "type": "GeneCombination", "id": "492" }, { "type": "GeneCombination", "id": "511" }, { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "519" }, { "type": "GeneCombination", "id": "547" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SCRIB/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SCRIB/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SCRIB/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }