Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/537/genes/?format=api
{ "data": [ { "type": "Gene", "id": "BRCA1", "attributes": { "go_molecular_function": [ "['DNA binding', 'zinc ion binding', 'ubiquitin-protein transferase activity', 'enzyme binding', 'ubiquitin protein ligase binding', 'tubulin binding', 'RNA polymerase binding', 'damaged DNA binding', 'transcription cis-regulatory region binding', 'RNA binding', 'transcription coactivator activity', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa01524", "kegg_path:hsa03440", "kegg_path:hsa03460", "kegg_path:hsa04120", "kegg_path:hsa04151", "kegg_path:hsa05206", "kegg_path:hsa05224", "R-HSA-1221632", "R-HSA-1474165", "R-HSA-1500620", "R-HSA-1640170", "R-HSA-1643685", "R-HSA-212436", "R-HSA-2990846", "R-HSA-3108214", "R-HSA-3108232", "R-HSA-3700989", "R-HSA-392499", "R-HSA-5633007", "R-HSA-5685938", "R-HSA-5685942", "R-HSA-5688426", "R-HSA-5689901", "R-HSA-5693532", "R-HSA-5693537", "R-HSA-5693538", "R-HSA-5693554", "R-HSA-5693565", "R-HSA-5693567", "R-HSA-5693568", "R-HSA-5693571", "R-HSA-5693579", "R-HSA-5693606", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-597592", "R-HSA-6796648", "R-HSA-6804756", "R-HSA-69473", "R-HSA-69481", "R-HSA-69620", "R-HSA-73857", "R-HSA-73894", "R-HSA-74160", "R-HSA-8953750", "R-HSA-912446", "R-HSA-9663199", "R-HSA-9675135", "R-HSA-9675136", "R-HSA-9699150" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P38398", "ensembl_id": "None", "entrez_id": "ENSG00000012048", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.735442" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1586" }, { "type": "SmallVariant", "id": "1655" }, { "type": "SmallVariant", "id": "3591" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BRCA1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BRCA1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "511" }, { "type": "GeneCombination", "id": "537" }, { "type": "GeneCombination", "id": "1209" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BRCA1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BRCA1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/BRCA1/?format=api" } }, { "type": "Gene", "id": "DLC1", "attributes": { "go_molecular_function": [ "GTPase activator activity", "lipid binding", "protein binding" ], "pathway_id": [ "R-HSA-194315", "R-HSA-194840", "R-HSA-162582" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q96QB1", "ensembl_id": "ENSG00000164741", "entrez_id": "10395", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.699643" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1523" }, { "type": "SmallVariant", "id": "1656" }, { "type": "SmallVariant", "id": "1676" }, { "type": "SmallVariant", "id": "1690" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DLC1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DLC1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "488" }, { "type": "GeneCombination", "id": "537" }, { "type": "GeneCombination", "id": "546" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DLC1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DLC1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DLC1/?format=api" } }, { "type": "Gene", "id": "SALL2", "attributes": { "go_molecular_function": [ "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "protein binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "DNA binding", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "metal ion binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9Y467", "ensembl_id": "ENSG00000165821", "entrez_id": "6297", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.473370" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1532" }, { "type": "SmallVariant", "id": "1590" }, { "type": "SmallVariant", "id": "1653" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SALL2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SALL2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "492" }, { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "521" }, { "type": "GeneCombination", "id": "537" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SALL2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SALL2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SALL2/?format=api" } }, { "type": "Gene", "id": "TMEM231", "attributes": { "go_molecular_function": [ "protein binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9H6L2", "ensembl_id": "ENSG00000205084", "entrez_id": "79583", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.288551" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1654" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TMEM231/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TMEM231/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "537" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TMEM231/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TMEM231/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TMEM231/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }