Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1218/genes/?format=api
{ "data": [ { "type": "Gene", "id": "KMT2C", "attributes": { "go_molecular_function": [ "['DNA binding', 'histone binding', 'protein binding', 'RNA binding', 'transcription coactivator activity', 'histone methyltransferase activity (H3-K4 specific)', 'acyltransferase activity', 'metal ion binding', 'histone methyltransferase activity']" ], "pathway_id": [ "kegg_path:hsa00310", "kegg_path:hsa01100", "R-HSA-1266738", "R-HSA-212436", "R-HSA-3214841", "R-HSA-3247509", "R-HSA-4839726", "R-HSA-5617472", "R-HSA-5619507", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878171", "R-HSA-8936459" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q8NEZ4", "ensembl_id": "None", "entrez_id": "ENSG00000055609", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.497998" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "683" }, { "type": "SmallVariant", "id": "3622" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KMT2C/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KMT2C/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "221" }, { "type": "GeneCombination", "id": "1218" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KMT2C/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KMT2C/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/KMT2C/?format=api" } }, { "type": "Gene", "id": "KMT5A", "attributes": { "go_molecular_function": [ "['histone-lysine N-methyltransferase activity', 'lysine N-methyltransferase activity', 'p53 binding', 'protein binding', 'transcription corepressor activity', 'protein-lysine N-methyltransferase activity', 'histone methyltransferase activity (H4-K20 specific)']" ], "pathway_id": [ "kegg_path:hsa00310", "kegg_path:hsa01100", "R-HSA-1640170", "R-HSA-212436", "R-HSA-2299718", "R-HSA-3214841", "R-HSA-3247509", "R-HSA-3700989", "R-HSA-4839726", "R-HSA-5633007", "R-HSA-6804760", "R-HSA-68875", "R-HSA-68886", "R-HSA-69278", "R-HSA-73857", "R-HSA-74160" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NQR1", "ensembl_id": "None", "entrez_id": "ENSG00000183955", "chromosome_number": "12", "lastmodified": "2024-02-29T15:02:20.740084" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3623" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KMT5A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KMT5A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1218" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KMT5A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KMT5A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/KMT5A/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }