Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/316/genes/?format=api
{ "data": [ { "type": "Gene", "id": "C19orf12", "attributes": { "go_molecular_function": [], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9NSK7", "ensembl_id": "ENSG00000131943", "entrez_id": "83636", "chromosome_number": "19", "lastmodified": "2021-10-18T11:00:44.757142" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "983" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/C19orf12/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/C19orf12/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "316" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/C19orf12/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/C19orf12/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/C19orf12/?format=api" } }, { "type": "Gene", "id": "CP", "attributes": { "go_molecular_function": [ "copper ion binding", "chaperone binding", "ferroxidase activity", "metal ion binding", "oxidoreductase activity" ], "pathway_id": [ "R-HSA-425410", "R-HSA-5619102", "R-HSA-382551", "kegg_path:hsa04216", "R-HSA-5619115", "kegg_path:hsa00860", "R-HSA-425366", "kegg_path:hsa04216", "R-HSA-597592", "kegg_path:hsa00860", "R-HSA-1643685", "R-HSA-381426", "R-HSA-425407", "R-HSA-392499", "R-HSA-5619060", "R-HSA-917937", "R-HSA-5619049", "R-HSA-8957275" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P00450", "ensembl_id": "ENSG00000047457", "entrez_id": "1356", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.535743" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "984" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CP/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CP/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "316" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CP/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CP/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CP/?format=api" } }, { "type": "Gene", "id": "PLA2G6", "attributes": { "go_molecular_function": [ "palmitoyl-CoA hydrolase activity", "lysophospholipase activity", "hydrolase activity", "1-alkyl-2-acetylglycerophosphocholine esterase activity", "calcium-independent phospholipase A2 activity", "calmodulin binding" ], "pathway_id": [ "R-HSA-8856688", "R-HSA-168249", "kegg_path:hsa00591", "kegg_path:hsa04270", "R-HSA-1483257", "kegg_path:hsa00565", "R-HSA-1482798", "R-HSA-6811436", "R-HSA-168256", "R-HSA-1483206", "R-HSA-1430728", "kegg_path:hsa00592", "R-HSA-1482788", "kegg_path:hsa00590", "R-HSA-199991", "kegg_path:hsa00564", "kegg_path:hsa01100", "R-HSA-2029480", "R-HSA-556833", "kegg_path:hsa04014", "kegg_path:hsa04666", "R-HSA-5653656", "R-HSA-6811442", "R-HSA-2029485", "kegg_path:hsa04750", "R-HSA-1482839" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O60733", "ensembl_id": "ENSG00000184381", "entrez_id": "8398", "chromosome_number": "22", "lastmodified": "2021-10-18T11:00:44.912199" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "CopyNumberVariant", "id": "986" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PLA2G6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PLA2G6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "316" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PLA2G6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PLA2G6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PLA2G6/?format=api" } }, { "type": "Gene", "id": "TPP1", "attributes": { "go_molecular_function": [ "protein binding", "tripeptidyl-peptidase activity", "serine-type endopeptidase activity", "sulfatide binding", "peptidase activity", "hydrolase activity", "serine-type peptidase activity", "lysophosphatidic acid binding", "endopeptidase activity", "metal ion binding" ], "pathway_id": [ "R-HSA-381119", "kegg_path:hsa04142", "R-HSA-381070", "R-HSA-392499", "R-HSA-381038" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O14773", "ensembl_id": "ENSG00000166340", "entrez_id": "1200", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.847725" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "651" }, { "type": "SmallVariant", "id": "985" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TPP1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TPP1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "316" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TPP1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TPP1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TPP1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }