Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/932/genes/?format=api
{ "data": [ { "type": "Gene", "id": "H2BW2", "attributes": { "go_molecular_function": [ "['DNA binding', 'protein heterodimerization activity']" ], "pathway_id": [ "kegg_path:hsa04613", "kegg_path:hsa05034", "kegg_path:hsa05203", "kegg_path:hsa05322" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P0C1H6", "ensembl_id": "None", "entrez_id": "ENSG00000101812", "chromosome_number": "X", "lastmodified": "2023-05-16T12:02:32.860453" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2789" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/H2BW2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/H2BW2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "932" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/H2BW2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/H2BW2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/H2BW2/?format=api" } }, { "type": "Gene", "id": "KDM6A", "attributes": { "go_molecular_function": [ "['RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'chromatin DNA binding', 'histone demethylase activity', 'protein binding', 'metal ion binding', 'histone H3-tri/di-methyl-lysine-27 demethylase activity']" ], "pathway_id": [ "kegg_path:hsa05202", "R-HSA-1266738", "R-HSA-3214842", "R-HSA-3247509", "R-HSA-4839726", "R-HSA-5617472", "R-HSA-5619507" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O15550", "ensembl_id": "None", "entrez_id": "ENSG00000147050", "chromosome_number": "X", "lastmodified": "2023-05-16T12:02:32.854428" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2788" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KDM6A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KDM6A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "932" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KDM6A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KDM6A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/KDM6A/?format=api" } }, { "type": "Gene", "id": "LRP1B", "attributes": { "go_molecular_function": [ "['calcium ion binding', 'protein binding', 'low-density lipoprotein particle receptor activity']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NZR2", "ensembl_id": "None", "entrez_id": "ENSG00000168702", "chromosome_number": "2", "lastmodified": "2023-05-16T12:02:32.849547" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "2786" }, { "type": "SmallVariant", "id": "2787" }, { "type": "SmallVariant", "id": "3572" }, { "type": "SmallVariant", "id": "3576" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRP1B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRP1B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "932" }, { "type": "GeneCombination", "id": "1203" }, { "type": "GeneCombination", "id": "1204" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRP1B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRP1B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LRP1B/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }