Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/874/genes/?format=api
{ "data": [ { "type": "Gene", "id": "NOD2", "attributes": { "go_molecular_function": [ "['muramyl dipeptide binding', 'enzyme binding', 'pattern recognition receptor activity', 'protein kinase binding', 'peptidoglycan binding', 'protein binding', 'CARD domain binding', 'protein-containing complex binding', 'actin binding', 'Hsp70 protein binding', 'Hsp90 protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa04621", "kegg_path:hsa04668", "kegg_path:hsa05152", "kegg_path:hsa05321", "R-HSA-1280215", "R-HSA-166016", "R-HSA-166058", "R-HSA-166166", "R-HSA-168138", "R-HSA-168142", "R-HSA-168164", "R-HSA-168176", "R-HSA-168179", "R-HSA-168181", "R-HSA-168188", "R-HSA-168249", "R-HSA-168256", "R-HSA-168638", "R-HSA-168643", "R-HSA-168898", "R-HSA-181438", "R-HSA-392499", "R-HSA-445989", "R-HSA-446652", "R-HSA-448424", "R-HSA-449147", "R-HSA-450294", "R-HSA-450302", "R-HSA-450321", "R-HSA-5688426", "R-HSA-5689896", "R-HSA-597592", "R-HSA-9020702", "R-HSA-937061", "R-HSA-975138", "R-HSA-975155", "R-HSA-975871" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9HC29", "ensembl_id": "None", "entrez_id": "ENSG00000167207", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.336498" }, "relationships": { "variant_set": { "meta": { "count": 15 }, "data": [ { "type": "SmallVariant", "id": "269" }, { "type": "SmallVariant", "id": "2628" }, { "type": "SmallVariant", "id": "3714" }, { "type": "SmallVariant", "id": "3716" }, { "type": "SmallVariant", "id": "3718" }, { "type": "SmallVariant", "id": "3719" }, { "type": "SmallVariant", "id": "3724" }, { "type": "SmallVariant", "id": "3725" }, { "type": "SmallVariant", "id": "3726" }, { "type": "SmallVariant", "id": "3728" }, { "type": "SmallVariant", "id": "3731" }, { "type": "SmallVariant", "id": "3735" }, { "type": "SmallVariant", "id": "3738" }, { "type": "SmallVariant", "id": "3740" }, { "type": "SmallVariant", "id": "3741" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOD2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOD2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 12 }, "data": [ { "type": "GeneCombination", "id": "97" }, { "type": "GeneCombination", "id": "874" }, { "type": "GeneCombination", "id": "1266" }, { "type": "GeneCombination", "id": "1265" }, { "type": "GeneCombination", "id": "1264" }, { "type": "GeneCombination", "id": "1263" }, { "type": "GeneCombination", "id": "1262" }, { "type": "GeneCombination", "id": "1261" }, { "type": "GeneCombination", "id": "1259" }, { "type": "GeneCombination", "id": "1260" }, { "type": "GeneCombination", "id": "1258" }, { "type": "GeneCombination", "id": "1257" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOD2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOD2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOD2/?format=api" } }, { "type": "Gene", "id": "NPC1", "attributes": { "go_molecular_function": [ "['signaling receptor activity', 'transmembrane signaling receptor activity', 'sterol transporter activity', 'protein binding', 'virus receptor activity', 'cholesterol binding']" ], "pathway_id": [ "kegg_path:hsa04142", "kegg_path:hsa04979", "R-HSA-174824", "R-HSA-382551", "R-HSA-8964038", "R-HSA-8964043" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O15118", "ensembl_id": "None", "entrez_id": "ENSG00000141458", "chromosome_number": "18", "lastmodified": "2022-08-04T14:14:59.966987" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2006" }, { "type": "SmallVariant", "id": "2629" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NPC1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NPC1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "691" }, { "type": "GeneCombination", "id": "874" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NPC1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NPC1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NPC1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }