Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1214/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ALS2", "attributes": { "go_molecular_function": [ "['protein homodimerization activity', 'small GTPase binding', 'guanyl-nucleotide exchange factor activity', 'protein binding', 'protein serine/threonine kinase activator activity', 'identical protein binding', 'GTPase activator activity']" ], "pathway_id": [ "kegg_path:hsa05014", "kegg_path:hsa05022", "R-HSA-199991", "R-HSA-5653656", "R-HSA-8876198", "R-HSA-9007101" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q96Q42", "ensembl_id": "None", "entrez_id": "ENSG00000003393", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.982160" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1706" }, { "type": "SmallVariant", "id": "1713" }, { "type": "SmallVariant", "id": "2064" }, { "type": "SmallVariant", "id": "3611" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALS2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALS2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "558" }, { "type": "GeneCombination", "id": "562" }, { "type": "GeneCombination", "id": "712" }, { "type": "GeneCombination", "id": "1214" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALS2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALS2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ALS2/?format=api" } }, { "type": "Gene", "id": "NEFH", "attributes": { "go_molecular_function": [ "['structural constituent of cytoskeleton', 'protein-macromolecule adaptor activity', 'protein kinase binding', 'kinesin binding', 'microtubule binding', 'protein binding', 'structural constituent of postsynaptic intermediate filament cytoskeleton', 'dynein complex binding']" ], "pathway_id": [ "kegg_path:hsa05014", "kegg_path:hsa05022" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P12036", "ensembl_id": "None", "entrez_id": "ENSG00000100285", "chromosome_number": "22", "lastmodified": "2021-10-18T11:00:44.660683" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "939" }, { "type": "SmallVariant", "id": "931" }, { "type": "SmallVariant", "id": "1816" }, { "type": "SmallVariant", "id": "3428" }, { "type": "SmallVariant", "id": "3449" }, { "type": "SmallVariant", "id": "3613" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NEFH/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NEFH/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "294" }, { "type": "GeneCombination", "id": "299" }, { "type": "GeneCombination", "id": "601" }, { "type": "GeneCombination", "id": "1150" }, { "type": "GeneCombination", "id": "1159" }, { "type": "GeneCombination", "id": "1214" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NEFH/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NEFH/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NEFH/?format=api" } }, { "type": "Gene", "id": "SPG11", "attributes": { "go_molecular_function": [ "['protein binding']" ], "pathway_id": [ "kegg_path:hsa05014", "kegg_path:hsa05022" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96JI7", "ensembl_id": "None", "entrez_id": "ENSG00000104133", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:45.010383" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "515" }, { "type": "SmallVariant", "id": "691" }, { "type": "SmallVariant", "id": "1377" }, { "type": "SmallVariant", "id": "2042" }, { "type": "SmallVariant", "id": "2043" }, { "type": "SmallVariant", "id": "2091" }, { "type": "SmallVariant", "id": "2097" }, { "type": "SmallVariant", "id": "2098" }, { "type": "SmallVariant", "id": "3062" }, { "type": "SmallVariant", "id": "3612" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SPG11/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SPG11/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "170" }, { "type": "GeneCombination", "id": "222" }, { "type": "GeneCombination", "id": "433" }, { "type": "GeneCombination", "id": "703" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "1027" }, { "type": "GeneCombination", "id": "1214" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SPG11/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SPG11/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SPG11/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }