Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/514/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ADGRA3", "attributes": { "go_molecular_function": [ "G protein-coupled receptor activity", "protein binding", "transmembrane signaling receptor activity" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8IWK6", "ensembl_id": "ENSG00000152990", "entrez_id": "166647", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:45.000925" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1598" }, { "type": "SmallVariant", "id": "1633" }, { "type": "SmallVariant", "id": "1679" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADGRA3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADGRA3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "514" }, { "type": "GeneCombination", "id": "528" }, { "type": "GeneCombination", "id": "547" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADGRA3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADGRA3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ADGRA3/?format=api" } }, { "type": "Gene", "id": "GART", "attributes": { "go_molecular_function": [ "phosphoribosylglycinamide formyltransferase activity", "transferase activity", "nucleotide binding", "ligase activity", "catalytic activity", "phosphoribosylformylglycinamidine cyclo-ligase activity", "phosphoribosylamine-glycine ligase activity", "metal ion binding" ], "pathway_id": [ "R-HSA-73817", "kegg_path:hsa01100", "kegg_path:hsa01523", "R-HSA-15869", "R-HSA-8956320", "R-HSA-1430728", "kegg_path:hsa00670", "kegg_path:hsa00230" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P22102", "ensembl_id": "ENSG00000159131", "entrez_id": "2618", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.738512" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1600" }, { "type": "SmallVariant", "id": "1640" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GART/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GART/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "514" }, { "type": "GeneCombination", "id": "531" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GART/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GART/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GART/?format=api" } }, { "type": "Gene", "id": "TXN2", "attributes": { "go_molecular_function": [ "protein binding", "protein-disulfide reductase activity" ], "pathway_id": [ "R-HSA-1614558", "kegg_path:hsa05132", "R-HSA-71291", "R-HSA-1614635", "R-HSA-1430728", "kegg_path:hsa05012", "R-HSA-3299685", "kegg_path:hsa04621", "kegg_path:hsa05418", "R-HSA-8953897", "R-HSA-2262752" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q99757", "ensembl_id": "ENSG00000100348", "entrez_id": "25828", "chromosome_number": "22", "lastmodified": "2021-10-18T11:00:44.746690" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1599" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TXN2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TXN2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "514" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TXN2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TXN2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TXN2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }