Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/669/genes/?format=api
{ "data": [ { "type": "Gene", "id": "EGF", "attributes": { "go_molecular_function": [ "calcium ion binding", "protein binding", "epidermal growth factor receptor binding", "transmembrane receptor protein tyrosine kinase activator activity", "growth factor activity", "guanyl-nucleotide exchange factor activity" ], "pathway_id": [ "R-HSA-1236382", "R-HSA-5663202", "kegg_path:hsa05200", "kegg_path:hsa04540", "R-HSA-9665348", "R-HSA-179812", "kegg_path:hsa04020", "R-HSA-162582", "R-HSA-1963642", "R-HSA-9013507", "R-HSA-2219530", "R-HSA-182971", "kegg_path:hsa04012", "R-HSA-9006934", "R-HSA-157118", "R-HSA-76002", "kegg_path:hsa05235", "R-HSA-109582", "R-HSA-8848021", "R-HSA-9664565", "kegg_path:hsa04015", "R-HSA-199418", "R-HSA-5653656", "R-HSA-1251932", "kegg_path:hsa05210", "R-HSA-5673001", "kegg_path:hsa05219", "R-HSA-1250196", "R-HSA-1227986", "R-HSA-1236394", "R-HSA-1257604", "R-HSA-9006925", "R-HSA-177929", "kegg_path:hsa05214", "R-HSA-1227990", "R-HSA-5638303", "R-HSA-5637812", "R-HSA-76005", "R-HSA-8863795", "kegg_path:hsa05165", "kegg_path:hsa05215", "R-HSA-6811558", "kegg_path:hsa04014", "R-HSA-5683057", "kegg_path:hsa04066", "R-HSA-1643713", "R-HSA-5637810", "kegg_path:hsa04810", "kegg_path:hsa05231", "R-HSA-2219528", "R-HSA-180292", "R-HSA-180336", "kegg_path:hsa04068", "R-HSA-1963640", "R-HSA-8939211", "kegg_path:hsa01521", "R-HSA-6785631", "R-HSA-8856825", "kegg_path:hsa04510", "R-HSA-5637815", "kegg_path:hsa05226", "R-HSA-9006927", "R-HSA-9634638", "kegg_path:hsa05218", "kegg_path:hsa04072", "R-HSA-114608", "R-HSA-8856828", "kegg_path:hsa05224", "R-HSA-9012852", "R-HSA-212718", "kegg_path:hsa04010", "kegg_path:hsa05213", "kegg_path:hsa05223", "R-HSA-5684996", "R-HSA-9009391", "kegg_path:hsa04630", "kegg_path:hsa05160", "R-HSA-5638302", "R-HSA-9665686", "R-HSA-199991", "R-HSA-8847993", "R-HSA-9006931", "kegg_path:hsa05212", "kegg_path:hsa04151", "R-HSA-1643685" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P01133", "ensembl_id": "ENSG00000138798", "entrez_id": "1950", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.414266" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1850" }, { "type": "SmallVariant", "id": "1883" }, { "type": "SmallVariant", "id": "1909" }, { "type": "SmallVariant", "id": "1956" }, { "type": "SmallVariant", "id": "2161" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EGF/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EGF/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "614" }, { "type": "GeneCombination", "id": "627" }, { "type": "GeneCombination", "id": "641" }, { "type": "GeneCombination", "id": "669" }, { "type": "GeneCombination", "id": "676" }, { "type": "GeneCombination", "id": "736" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EGF/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EGF/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/EGF/?format=api" } }, { "type": "Gene", "id": "GHR", "attributes": { "go_molecular_function": [ "['peptide hormone binding', 'proline-rich region binding', 'SH2 domain binding', 'growth hormone receptor activity', 'protein kinase binding', 'cytokine binding', 'protein phosphatase binding', 'protein binding', 'growth factor binding', 'protein homodimerization activity', 'cytokine receptor activity', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04060", "kegg_path:hsa04080", "kegg_path:hsa04151", "kegg_path:hsa04630", "kegg_path:hsa04935", "R-HSA-1170546", "R-HSA-1280215", "R-HSA-168256", "R-HSA-982772" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10912", "ensembl_id": "None", "entrez_id": "ENSG00000112964", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.556257" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "1957" }, { "type": "SmallVariant", "id": "1967" }, { "type": "SmallVariant", "id": "3219" }, { "type": "SmallVariant", "id": "3222" }, { "type": "SmallVariant", "id": "3232" }, { "type": "SmallVariant", "id": "3249" }, { "type": "SmallVariant", "id": "3269" }, { "type": "SmallVariant", "id": "3279" }, { "type": "SmallVariant", "id": "3330" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 10 }, "data": [ { "type": "GeneCombination", "id": "669" }, { "type": "GeneCombination", "id": "674" }, { "type": "GeneCombination", "id": "1076" }, { "type": "GeneCombination", "id": "1077" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1089" }, { "type": "GeneCombination", "id": "1099" }, { "type": "GeneCombination", "id": "1103" }, { "type": "GeneCombination", "id": "1123" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/?format=api" } }, { "type": "Gene", "id": "MET", "attributes": { "go_molecular_function": [ "protein tyrosine kinase activity", "protein binding" ], "pathway_id": [ "kegg_path:hsa05226", "R-HSA-8851805", "R-HSA-2219530", "kegg_path:hsa05202", "kegg_path:hsa01521", "kegg_path:hsa05206", "kegg_path:hsa05211", "kegg_path:hsa05100", "R-HSA-9006934", "kegg_path:hsa04015", "R-HSA-199418", "R-HSA-5663202", "kegg_path:hsa05200", "kegg_path:hsa04010", "kegg_path:hsa05223", "R-HSA-5684996", "R-HSA-8874081", "R-HSA-8875555", "R-HSA-162582", "kegg_path:hsa04020", "R-HSA-8865999", "kegg_path:hsa04014", "R-HSA-1266738", "kegg_path:hsa05205", "R-HSA-5663205", "R-HSA-8876384", "R-HSA-6807004", "kegg_path:hsa05202", "R-HSA-2219528", "R-HSA-400685", "R-HSA-8851907", "kegg_path:hsa01521", "kegg_path:hsa05206", "kegg_path:hsa05230", "kegg_path:hsa05211", "kegg_path:hsa05225", "kegg_path:hsa04151", "kegg_path:hsa04360", "kegg_path:hsa05226", "kegg_path:hsa05120", "kegg_path:hsa04510", "R-HSA-73857", "R-HSA-8986944", "R-HSA-9022699", "kegg_path:hsa04015", "R-HSA-8875513", "kegg_path:hsa04520", "kegg_path:hsa05100", "kegg_path:hsa05218", "kegg_path:hsa04010", "kegg_path:hsa05223", "R-HSA-5673001", "R-HSA-416550", "kegg_path:hsa04020", "R-HSA-8875878", "R-HSA-6806942", "kegg_path:hsa05144", "R-HSA-8875656", "R-HSA-9006925", "kegg_path:hsa05200", "R-HSA-1257604", "R-HSA-8875360", "kegg_path:hsa05205", "R-HSA-8875791", "R-HSA-212436", "R-HSA-6811558", "R-HSA-422475", "kegg_path:hsa04014", "R-HSA-5683057", "R-HSA-9675108", "kegg_path:hsa04151", "kegg_path:hsa04360", "R-HSA-1643685", "kegg_path:hsa04510", "kegg_path:hsa05120", "kegg_path:hsa05230", "kegg_path:hsa05225", "kegg_path:hsa04520", "kegg_path:hsa05218", "R-HSA-6806834", "R-HSA-373755", "R-HSA-74160", "kegg_path:hsa05144" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P08581", "ensembl_id": "ENSG00000105976", "entrez_id": "4233", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.557330" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1062" }, { "type": "SmallVariant", "id": "1873" }, { "type": "SmallVariant", "id": "1958" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MET/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MET/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "346" }, { "type": "GeneCombination", "id": "622" }, { "type": "GeneCombination", "id": "669" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MET/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MET/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MET/?format=api" } }, { "type": "Gene", "id": "MTOR", "attributes": { "go_molecular_function": [ "['protein kinase activity', 'RNA polymerase III type 1 promoter sequence-specific DNA binding', 'identical protein binding', 'protein serine/threonine kinase activity', 'TFIIIC-class transcription factor complex binding', 'ATP binding', 'protein serine kinase activity', 'phosphoprotein binding', 'kinase activity', 'RNA polymerase III type 2 promoter sequence-specific DNA binding', 'protein binding', 'ribosome binding', 'RNA polymerase III type 3 promoter sequence-specific DNA binding', 'protein serine/threonine/tyrosine kinase activity']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa01522", "kegg_path:hsa04012", "kegg_path:hsa04066", "kegg_path:hsa04072", "kegg_path:hsa04136", "kegg_path:hsa04140", "kegg_path:hsa04150", "kegg_path:hsa04151", "kegg_path:hsa04152", "kegg_path:hsa04211", "kegg_path:hsa04213", "kegg_path:hsa04218", "kegg_path:hsa04371", "kegg_path:hsa04613", "kegg_path:hsa04630", "kegg_path:hsa04659", "kegg_path:hsa04714", "kegg_path:hsa04910", "kegg_path:hsa04919", "kegg_path:hsa04920", "kegg_path:hsa04930", "kegg_path:hsa04931", "kegg_path:hsa04935", "kegg_path:hsa05010", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05017", "kegg_path:hsa05022", "kegg_path:hsa05131", "kegg_path:hsa05163", "kegg_path:hsa05165", "kegg_path:hsa05167", "kegg_path:hsa05168", "kegg_path:hsa05170", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05206", "kegg_path:hsa05210", "kegg_path:hsa05212", "kegg_path:hsa05214", "kegg_path:hsa05215", "kegg_path:hsa05221", "kegg_path:hsa05224", "kegg_path:hsa05225", "kegg_path:hsa05226", "kegg_path:hsa05230", "kegg_path:hsa05231", "kegg_path:hsa05235", "R-HSA-1257604", "R-HSA-1280218", "R-HSA-162582", "R-HSA-1632852", "R-HSA-1643685", "R-HSA-165159", "R-HSA-166208", "R-HSA-168256", "R-HSA-194138", "R-HSA-212436", "R-HSA-2219528", "R-HSA-2262752", "R-HSA-3371556", "R-HSA-3371571", "R-HSA-3700989", "R-HSA-380972", "R-HSA-388841", "R-HSA-389356", "R-HSA-389357", "R-HSA-4420097", "R-HSA-5218920", "R-HSA-5628897", "R-HSA-5633007", "R-HSA-5663202", "R-HSA-5674400", "R-HSA-6804757", "R-HSA-6806003", "R-HSA-6807070", "R-HSA-73857", "R-HSA-74160", "R-HSA-8943724", "R-HSA-8953897", "R-HSA-9006925", "R-HSA-9006934", "R-HSA-9612973", "R-HSA-9639288" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P42345", "ensembl_id": "None", "entrez_id": "ENSG00000198793", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.474959" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1881" }, { "type": "SmallVariant", "id": "1913" }, { "type": "SmallVariant", "id": "1959" }, { "type": "SmallVariant", "id": "2621" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTOR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTOR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "626" }, { "type": "GeneCombination", "id": "643" }, { "type": "GeneCombination", "id": "669" }, { "type": "GeneCombination", "id": "871" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTOR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTOR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MTOR/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }