Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/533/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ALX1", "attributes": { "go_molecular_function": [ "protein binding", "DNA binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "sequence-specific double-stranded DNA binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15699", "ensembl_id": "ENSG00000180318", "entrez_id": "8092", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.526993" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1561" }, { "type": "SmallVariant", "id": "1576" }, { "type": "SmallVariant", "id": "1610" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALX1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALX1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "502" }, { "type": "GeneCombination", "id": "507" }, { "type": "GeneCombination", "id": "518" }, { "type": "GeneCombination", "id": "533" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALX1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALX1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ALX1/?format=api" } }, { "type": "Gene", "id": "FAT4", "attributes": { "go_molecular_function": [ "protein binding", "calcium ion binding" ], "pathway_id": [ "kegg_path:hsa04392" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q6V0I7", "ensembl_id": "ENSG00000196159", "entrez_id": "79633", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.536840" }, "relationships": { "variant_set": { "meta": { "count": 12 }, "data": [ { "type": "SmallVariant", "id": "1507" }, { "type": "SmallVariant", "id": "1510" }, { "type": "SmallVariant", "id": "1511" }, { "type": "SmallVariant", "id": "1549" }, { "type": "SmallVariant", "id": "1556" }, { "type": "SmallVariant", "id": "1558" }, { "type": "SmallVariant", "id": "1559" }, { "type": "SmallVariant", "id": "1626" }, { "type": "SmallVariant", "id": "1643" }, { "type": "SmallVariant", "id": "1648" }, { "type": "SmallVariant", "id": "1675" }, { "type": "SmallVariant", "id": "1689" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FAT4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FAT4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 9 }, "data": [ { "type": "GeneCombination", "id": "497" }, { "type": "GeneCombination", "id": "484" }, { "type": "GeneCombination", "id": "485" }, { "type": "GeneCombination", "id": "500" }, { "type": "GeneCombination", "id": "501" }, { "type": "GeneCombination", "id": "524" }, { "type": "GeneCombination", "id": "533" }, { "type": "GeneCombination", "id": "535" }, { "type": "GeneCombination", "id": "546" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FAT4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FAT4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FAT4/?format=api" } }, { "type": "Gene", "id": "FZD1", "attributes": { "go_molecular_function": [ "Wnt-protein binding", "G protein-coupled receptor activity", "transmembrane signaling receptor activity", "Wnt-activated receptor activity" ], "pathway_id": [ "kegg_path:hsa05217", "kegg_path:hsa05225", "R-HSA-201681", "R-HSA-4641262", "kegg_path:hsa05226", "kegg_path:hsa04390", "kegg_path:hsa04934", "kegg_path:hsa05010", "kegg_path:hsa04550", "kegg_path:hsa05165", "R-HSA-4086400", "kegg_path:hsa04150", "R-HSA-3858494", "kegg_path:hsa05205", "kegg_path:hsa05224", "R-HSA-4608870", "kegg_path:hsa04916", "kegg_path:hsa05022", "kegg_path:hsa05200", "R-HSA-500792", "kegg_path:hsa04310", "R-HSA-195721", "R-HSA-373080", "R-HSA-162582", "R-HSA-372790" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9UP38", "ensembl_id": "ENSG00000157240", "entrez_id": "8321", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.508613" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1644" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FZD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FZD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "533" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FZD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FZD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FZD1/?format=api" } }, { "type": "Gene", "id": "ZNRF3", "attributes": { "go_molecular_function": [ "['ubiquitin-protein transferase activity', 'frizzled binding', 'protein binding', 'metal ion binding', 'ubiquitin protein ligase activity']" ], "pathway_id": [ "kegg_path:hsa04310", "R-HSA-162582", "R-HSA-195721", "R-HSA-201681", "R-HSA-4641263" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9ULT6", "ensembl_id": "None", "entrez_id": "ENSG00000183579", "chromosome_number": "22", "lastmodified": "2021-10-18T11:00:44.653587" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "1541" }, { "type": "SmallVariant", "id": "1555" }, { "type": "SmallVariant", "id": "1642" }, { "type": "SmallVariant", "id": "1673" }, { "type": "SmallVariant", "id": "3203" }, { "type": "SmallVariant", "id": "3235" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZNRF3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZNRF3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "494" }, { "type": "GeneCombination", "id": "500" }, { "type": "GeneCombination", "id": "533" }, { "type": "GeneCombination", "id": "545" }, { "type": "GeneCombination", "id": "1070" }, { "type": "GeneCombination", "id": "1075" }, { "type": "GeneCombination", "id": "1083" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZNRF3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZNRF3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZNRF3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }