Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1208/genes/?format=api
{ "data": [ { "type": "Gene", "id": "IDUA", "attributes": { "go_molecular_function": [ "['hydrolase activity, hydrolyzing O-glycosyl compounds', 'signaling receptor binding', 'L-iduronidase activity']" ], "pathway_id": [ "kegg_path:hsa00531", "kegg_path:hsa01100", "kegg_path:hsa04142", "R-HSA-1430728", "R-HSA-1630316", "R-HSA-1638091", "R-HSA-1643685", "R-HSA-1793185", "R-HSA-2024096", "R-HSA-2024101", "R-HSA-2206281", "R-HSA-2206302", "R-HSA-5663084", "R-HSA-5668914", "R-HSA-71387" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P35475", "ensembl_id": "None", "entrez_id": "ENSG00000127415", "chromosome_number": "4", "lastmodified": "2024-02-29T15:02:20.565955" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "3548" }, { "type": "SmallVariant", "id": "3557" }, { "type": "SmallVariant", "id": "3563" }, { "type": "SmallVariant", "id": "3589" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IDUA/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IDUA/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "1194" }, { "type": "GeneCombination", "id": "1197" }, { "type": "GeneCombination", "id": "1200" }, { "type": "GeneCombination", "id": "1208" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IDUA/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IDUA/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IDUA/?format=api" } }, { "type": "Gene", "id": "LOXL1", "attributes": { "go_molecular_function": [ "['protein-lysine 6-oxidase activity', 'protein binding', 'copper ion binding']" ], "pathway_id": [ "R-HSA-1474244", "R-HSA-1474290", "R-HSA-1566948", "R-HSA-2022090", "R-HSA-2243919" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q08397", "ensembl_id": "None", "entrez_id": "ENSG00000129038", "chromosome_number": "15", "lastmodified": "2024-02-29T15:02:20.651033" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3590" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LOXL1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LOXL1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1208" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LOXL1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LOXL1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LOXL1/?format=api" } }, { "type": "Gene", "id": "ZNF469", "attributes": { "go_molecular_function": [ "['DNA binding', 'metal ion binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96JG9", "ensembl_id": "None", "entrez_id": "ENSG00000225614", "chromosome_number": "16", "lastmodified": "2024-02-29T15:02:20.468522" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3514" }, { "type": "SmallVariant", "id": "3525" }, { "type": "SmallVariant", "id": "3588" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZNF469/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZNF469/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "1185" }, { "type": "GeneCombination", "id": "1189" }, { "type": "GeneCombination", "id": "1208" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZNF469/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZNF469/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZNF469/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }