Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1191/genes/?format=api
{ "data": [ { "type": "Gene", "id": "COL2A1", "attributes": { "go_molecular_function": [ "['MHC class II protein binding', 'extracellular matrix structural constituent conferring tensile strength', 'platelet-derived growth factor binding', 'proteoglycan binding', 'metal ion binding', 'identical protein binding', 'extracellular matrix structural constituent']" ], "pathway_id": [ "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa04974", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-1280218", "R-HSA-1442490", "R-HSA-1474228", "R-HSA-1474244", "R-HSA-1474290", "R-HSA-162582", "R-HSA-1650814", "R-HSA-168256", "R-HSA-186797", "R-HSA-198933", "R-HSA-2022090", "R-HSA-216083", "R-HSA-3000171", "R-HSA-3000178", "R-HSA-375165", "R-HSA-419037", "R-HSA-422475", "R-HSA-6806834", "R-HSA-8874081", "R-HSA-8875878", "R-HSA-8948216", "R-HSA-9006934", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P02458", "ensembl_id": "None", "entrez_id": "ENSG00000139219", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.966098" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1466" }, { "type": "SmallVariant", "id": "1470" }, { "type": "SmallVariant", "id": "3533" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL2A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL2A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "468" }, { "type": "GeneCombination", "id": "470" }, { "type": "GeneCombination", "id": "1191" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL2A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL2A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COL2A1/?format=api" } }, { "type": "Gene", "id": "COL4A4", "attributes": { "go_molecular_function": [ "['extracellular matrix structural constituent conferring tensile strength', 'extracellular matrix structural constituent']" ], "pathway_id": [ "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa04926", "kegg_path:hsa04933", "kegg_path:hsa04974", "kegg_path:hsa05146", "kegg_path:hsa05165", "kegg_path:hsa05200", "kegg_path:hsa05222", "R-HSA-1266738", "R-HSA-1442490", "R-HSA-1474228", "R-HSA-1474244", "R-HSA-1474290", "R-HSA-162582", "R-HSA-1650814", "R-HSA-186797", "R-HSA-2022090", "R-HSA-216083", "R-HSA-2214320", "R-HSA-2243919", "R-HSA-3000157", "R-HSA-3000171", "R-HSA-3000178", "R-HSA-375165", "R-HSA-419037", "R-HSA-422475", "R-HSA-8948216", "R-HSA-9006934", "R-HSA-9675108" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P53420", "ensembl_id": "None", "entrez_id": "ENSG00000081052", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.373825" }, "relationships": { "variant_set": { "meta": { "count": 30 }, "data": [ { "type": "SmallVariant", "id": "833" }, { "type": "SmallVariant", "id": "72" }, { "type": "SmallVariant", "id": "74" }, { "type": "SmallVariant", "id": "313" }, { "type": "SmallVariant", "id": "314" }, { "type": "SmallVariant", "id": "317" }, { "type": "SmallVariant", "id": "616" }, { "type": "SmallVariant", "id": "821" }, { "type": "SmallVariant", "id": "823" }, { "type": "SmallVariant", "id": "825" }, { "type": "SmallVariant", "id": "827" }, { "type": "SmallVariant", "id": "829" }, { "type": "SmallVariant", "id": "831" }, { "type": "SmallVariant", "id": "835" }, { "type": "SmallVariant", "id": "837" }, { "type": "SmallVariant", "id": "839" }, { "type": "SmallVariant", "id": "841" }, { "type": "SmallVariant", "id": "842" }, { "type": "SmallVariant", "id": "2106" }, { "type": "SmallVariant", "id": "2108" }, { "type": "SmallVariant", "id": "2110" }, { "type": "SmallVariant", "id": "2112" }, { "type": "SmallVariant", "id": "2641" }, { "type": "SmallVariant", "id": "2878" }, { "type": "SmallVariant", "id": "2880" }, { "type": "SmallVariant", "id": "2882" }, { "type": "SmallVariant", "id": "3460" }, { "type": "SmallVariant", "id": "3464" }, { "type": "SmallVariant", "id": "3466" }, { "type": "SmallVariant", "id": "3532" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL4A4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL4A4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "28" }, { "type": "GeneCombination", "id": "29" }, { "type": "GeneCombination", "id": "210" }, { "type": "GeneCombination", "id": "1191" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL4A4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL4A4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COL4A4/?format=api" } }, { "type": "Gene", "id": "COL6A3", "attributes": { "go_molecular_function": [ "['extracellular matrix structural constituent conferring tensile strength', 'serine-type endopeptidase inhibitor activity']" ], "pathway_id": [ "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa04974", "kegg_path:hsa05165", "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa04974", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-1442490", "R-HSA-1474228", "R-HSA-1474244", "R-HSA-1474290", "R-HSA-162582", "R-HSA-1650814", "R-HSA-186797", "R-HSA-2022090", "R-HSA-216083", "R-HSA-3000178", "R-HSA-375165", "R-HSA-419037", "R-HSA-422475", "R-HSA-8948216", "R-HSA-9006934", "R-HSA-9675108" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P12111", "ensembl_id": "None", "entrez_id": "ENSG00000163359", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.996739" }, "relationships": { "variant_set": { "meta": { "count": 8 }, "data": [ { "type": "SmallVariant", "id": "280" }, { "type": "SmallVariant", "id": "1191" }, { "type": "SmallVariant", "id": "1192" }, { "type": "SmallVariant", "id": "1728" }, { "type": "SmallVariant", "id": "1746" }, { "type": "SmallVariant", "id": "3530" }, { "type": "SmallVariant", "id": "3531" }, { "type": "SmallVariant", "id": "3690" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL6A3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL6A3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "100" }, { "type": "GeneCombination", "id": "382" }, { "type": "GeneCombination", "id": "569" }, { "type": "GeneCombination", "id": "575" }, { "type": "GeneCombination", "id": "1191" }, { "type": "GeneCombination", "id": "1247" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COL6A3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COL6A3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COL6A3/?format=api" } }, { "type": "Gene", "id": "TTN", "attributes": { "go_molecular_function": [ "['enzyme binding', 'calmodulin binding', 'structural constituent of muscle', 'protein serine/threonine/tyrosine kinase activity', 'actinin binding', 'muscle alpha-actinin binding', 'protein kinase binding', 'telethonin binding', 'actin filament binding', 'identical protein binding', 'calcium ion binding', 'structural molecule activity conferring elasticity', 'protein serine kinase activity', 'ATP binding', 'protein tyrosine kinase activity', 'protein self-association', 'protein binding', 'protease binding', 'protein serine/threonine kinase activity']" ], "pathway_id": [ "kegg_path:hsa05410", "kegg_path:hsa05414", "R-HSA-109582", "R-HSA-114608", "R-HSA-390522", "R-HSA-397014", "R-HSA-76002", "R-HSA-76005" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "A0A0A0MTS7", "ensembl_id": "None", "entrez_id": "ENSG00000155657", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.407776" }, "relationships": { "variant_set": { "meta": { "count": 20 }, "data": [ { "type": "SmallVariant", "id": "449" }, { "type": "SmallVariant", "id": "450" }, { "type": "SmallVariant", "id": "452" }, { "type": "SmallVariant", "id": "453" }, { "type": "SmallVariant", "id": "455" }, { "type": "SmallVariant", "id": "462" }, { "type": "SmallVariant", "id": "463" }, { "type": "SmallVariant", "id": "1451" }, { "type": "SmallVariant", "id": "2019" }, { "type": "SmallVariant", "id": "2782" }, { "type": "SmallVariant", "id": "2785" }, { "type": "SmallVariant", "id": "2809" }, { "type": "SmallVariant", "id": "2810" }, { "type": "SmallVariant", "id": "3529" }, { "type": "SmallVariant", "id": "3534" }, { "type": "SmallVariant", "id": "3560" }, { "type": "SmallVariant", "id": "3570" }, { "type": "SmallVariant", "id": "3760" }, { "type": "SmallVariant", "id": "3762" }, { "type": "SmallVariant", "id": "3764" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TTN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TTN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "148" }, { "type": "GeneCombination", "id": "149" }, { "type": "GeneCombination", "id": "150" }, { "type": "GeneCombination", "id": "153" }, { "type": "GeneCombination", "id": "463" }, { "type": "GeneCombination", "id": "695" }, { "type": "GeneCombination", "id": "930" }, { "type": "GeneCombination", "id": "931" }, { "type": "GeneCombination", "id": "937" }, { "type": "GeneCombination", "id": "1190" }, { "type": "GeneCombination", "id": "1191" }, { "type": "GeneCombination", "id": "1198" }, { "type": "GeneCombination", "id": "1202" }, { "type": "GeneCombination", "id": "1272" }, { "type": "GeneCombination", "id": "1273" }, { "type": "GeneCombination", "id": "1274" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TTN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TTN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TTN/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }