Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/759/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ANAPC1", "attributes": { "go_molecular_function": [ "molecular adaptor activity" ], "pathway_id": [ "R-HSA-69618", "R-HSA-174084", "R-HSA-2467813", "R-HSA-176409", "R-HSA-1640170", "R-HSA-174143", "R-HSA-212436", "R-HSA-983169", "R-HSA-168256", "R-HSA-174048", "R-HSA-69278", "R-HSA-141405", "R-HSA-2559583", "kegg_path:hsa04110", "kegg_path:hsa04120", "R-HSA-1280218", "R-HSA-453276", "R-HSA-174178", "R-HSA-68882", "R-HSA-1643685", "R-HSA-68886", "R-HSA-176408", "R-HSA-176412", "R-HSA-176814", "R-HSA-69620", "kegg_path:hsa04114", "kegg_path:hsa04914", "R-HSA-2555396", "R-HSA-69242", "R-HSA-73857", "R-HSA-69239", "R-HSA-8853884", "R-HSA-174184", "R-HSA-2559582", "R-HSA-69052", "R-HSA-8953897", "R-HSA-141430", "R-HSA-176407", "R-HSA-9687139", "R-HSA-74160", "R-HSA-9687136", "R-HSA-2262752", "R-HSA-9675126", "R-HSA-69306", "R-HSA-179419", "R-HSA-179409", "kegg_path:hsa05166", "R-HSA-69017", "R-HSA-174154", "R-HSA-983168" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9H1A4", "ensembl_id": "ENSG00000153107", "entrez_id": "64682", "chromosome_number": "2", "lastmodified": "2022-08-04T14:14:59.494952" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2250" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ANAPC1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ANAPC1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "759" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ANAPC1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ANAPC1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ANAPC1/?format=api" } }, { "type": "Gene", "id": "ATR", "attributes": { "go_molecular_function": [ "MutSalpha complex binding", "protein binding", "protein serine/threonine kinase activity", "DNA binding", "MutLalpha complex binding", "protein serine/threonine/tyrosine kinase activity", "protein kinase activity", "ATP binding", "protein serine kinase activity" ], "pathway_id": [ "R-HSA-3371556", "R-HSA-6783310", "kegg_path:hsa03460", "R-HSA-5685938", "R-HSA-5693532", "R-HSA-6796648", "R-HSA-1500620", "R-HSA-5693616", "R-HSA-8953897", "R-HSA-5633007", "kegg_path:hsa05165", "kegg_path:hsa05166", "R-HSA-5693607", "kegg_path:hsa04115", "R-HSA-69481", "R-HSA-1640170", "R-HSA-3371453", "kegg_path:hsa04218", "R-HSA-212436", "R-HSA-3700989", "R-HSA-5685942", "R-HSA-1474165", "kegg_path:hsa04110", "R-HSA-69473", "R-HSA-73894", "R-HSA-5693579", "R-HSA-6804756", "R-HSA-1221632", "R-HSA-176187", "kegg_path:hsa05170", "R-HSA-5693538", "R-HSA-73857", "R-HSA-5693567", "R-HSA-69620", "R-HSA-2262752", "R-HSA-74160" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13535", "ensembl_id": "ENSG00000175054", "entrez_id": "545", "chromosome_number": "3", "lastmodified": "2022-08-04T14:14:57.634607" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2251" }, { "type": "SmallVariant", "id": "2304" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "759" }, { "type": "GeneCombination", "id": "773" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ATR/?format=api" } }, { "type": "Gene", "id": "LARS2", "attributes": { "go_molecular_function": [ "leucine-tRNA ligase activity", "aminoacyl-tRNA editing activity", "ATP binding" ], "pathway_id": [ "R-HSA-392499", "R-HSA-379726", "R-HSA-72766", "R-HSA-379724", "kegg_path:hsa00970" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q15031", "ensembl_id": "ENSG00000011376", "entrez_id": "23395", "chromosome_number": "3", "lastmodified": "2022-08-04T14:14:58.977947" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "2246" }, { "type": "SmallVariant", "id": "2247" }, { "type": "SmallVariant", "id": "2290" }, { "type": "SmallVariant", "id": "2309" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LARS2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LARS2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "759" }, { "type": "GeneCombination", "id": "769" }, { "type": "GeneCombination", "id": "775" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LARS2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LARS2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LARS2/?format=api" } }, { "type": "Gene", "id": "MLH3", "attributes": { "go_molecular_function": [ "protein binding", "ATP hydrolysis activity", "satellite DNA binding", "chromatin binding", "centromeric DNA binding", "ATP binding", "mismatched DNA binding" ], "pathway_id": [ "R-HSA-1500620", "R-HSA-1474165", "R-HSA-912446", "kegg_path:hsa03430", "R-HSA-1640170" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9UHC1", "ensembl_id": "ENSG00000119684", "entrez_id": "27030", "chromosome_number": "14", "lastmodified": "2022-08-04T14:14:59.094856" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2248" }, { "type": "SmallVariant", "id": "2337" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MLH3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MLH3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "759" }, { "type": "GeneCombination", "id": "788" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MLH3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MLH3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MLH3/?format=api" } }, { "type": "Gene", "id": "POLE", "attributes": { "go_molecular_function": [ "single-stranded DNA 3'-5' exodeoxyribonuclease activity", "protein binding", "DNA-directed DNA polymerase activity", "4 iron, 4 sulfur cluster binding", "DNA binding", "nucleotide binding", "chromatin binding", "zinc ion binding" ], "pathway_id": [ "R-HSA-453279", "R-HSA-6781827", "R-HSA-73884", "R-HSA-5656169", "R-HSA-5696397", "R-HSA-73933", "R-HSA-69278", "R-HSA-73894", "R-HSA-5696398", "R-HSA-69239", "R-HSA-5693538", "R-HSA-69242", "kegg_path:hsa03420", "R-HSA-5696399", "R-HSA-5693567", "kegg_path:hsa03030", "R-HSA-69002", "R-HSA-110373", "R-HSA-110314", "R-HSA-5693532", "R-HSA-69206", "R-HSA-68962", "R-HSA-110313", "R-HSA-6782135", "R-HSA-68952", "R-HSA-5651801", "R-HSA-73893", "R-HSA-5696400", "R-HSA-6782210", "R-HSA-1640170", "R-HSA-69306", "kegg_path:hsa03410", "R-HSA-5685942" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q07864", "ensembl_id": "ENSG00000177084", "entrez_id": "5426", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:58.293972" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2249" }, { "type": "SmallVariant", "id": "2444" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POLE/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POLE/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "759" }, { "type": "GeneCombination", "id": "823" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POLE/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POLE/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/POLE/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }