Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/646/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FEZ1", "attributes": { "go_molecular_function": [ "protein binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q99689", "ensembl_id": "ENSG00000149557", "entrez_id": "9638", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.368679" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1918" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FEZ1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FEZ1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "646" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FEZ1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FEZ1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FEZ1/?format=api" } }, { "type": "Gene", "id": "IGF1", "attributes": { "go_molecular_function": [ "insulin-like growth factor receptor binding", "integrin binding" ], "pathway_id": [ "kegg_path:hsa04935", "R-HSA-2428924", "kegg_path:hsa04151", "R-HSA-381426", "R-HSA-2428933", "kegg_path:hsa05410", "R-HSA-9006934", "R-HSA-76002", "kegg_path:hsa04150", "R-HSA-109582", "kegg_path:hsa04015", "kegg_path:hsa04114", "kegg_path:hsa04914", "R-HSA-114608", "kegg_path:hsa04730", "kegg_path:hsa05224", "kegg_path:hsa05200", "kegg_path:hsa04152", "kegg_path:hsa04750", "kegg_path:hsa05414", "kegg_path:hsa04010", "R-HSA-162582", "kegg_path:hsa05214", "R-HSA-76005", "kegg_path:hsa04550", "kegg_path:hsa05215", "kegg_path:hsa01522", "kegg_path:hsa05205", "R-HSA-422085", "kegg_path:hsa04014", "kegg_path:hsa04115", "kegg_path:hsa04960", "kegg_path:hsa04066", "R-HSA-2428928", "kegg_path:hsa05202", "R-HSA-2980736", "R-HSA-392499", "kegg_path:hsa04211", "kegg_path:hsa04913", "kegg_path:hsa04068", "kegg_path:hsa01521", "R-HSA-2404192", "kegg_path:hsa04510", "kegg_path:hsa04213", "kegg_path:hsa05218" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P05019", "ensembl_id": "ENSG00000017427", "entrez_id": "3479", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.282328" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1904" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IGF1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IGF1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "638" }, { "type": "GeneCombination", "id": "645" }, { "type": "GeneCombination", "id": "646" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IGF1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IGF1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IGF1/?format=api" } }, { "type": "Gene", "id": "PAX6", "attributes": { "go_molecular_function": [ "protein kinase binding", "histone acetyltransferase binding" ], "pathway_id": [ "R-HSA-400511", "R-HSA-2980736", "R-HSA-392499", "kegg_path:hsa04550", "kegg_path:hsa04950", "R-HSA-5619507", "R-HSA-400508", "R-HSA-381771", "R-HSA-1266738", "kegg_path:hsa04550", "kegg_path:hsa04950", "R-HSA-5617472", "R-HSA-186712", "R-HSA-210745" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P26367", "ensembl_id": "ENSG00000007372", "entrez_id": "5080", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.236412" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1917" }, { "type": "SmallVariant", "id": "1928" }, { "type": "SmallVariant", "id": "1933" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PAX6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PAX6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "645" }, { "type": "GeneCombination", "id": "646" }, { "type": "GeneCombination", "id": "651" }, { "type": "GeneCombination", "id": "653" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PAX6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PAX6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PAX6/?format=api" } }, { "type": "Gene", "id": "PLXNB1", "attributes": { "go_molecular_function": [ "semaphorin receptor activity", "GTPase activator activity", "protein binding" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-416482", "R-HSA-9675108", "R-HSA-373755", "R-HSA-416572", "R-HSA-422475", "R-HSA-400685", "R-HSA-388396", "kegg_path:hsa04360", "R-HSA-416550", "R-HSA-162582", "R-HSA-372790" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O43157", "ensembl_id": "ENSG00000164050", "entrez_id": "5364", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.887426" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1900" }, { "type": "SmallVariant", "id": "1915" }, { "type": "SmallVariant", "id": "1919" }, { "type": "SmallVariant", "id": "1935" }, { "type": "SmallVariant", "id": "1953" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PLXNB1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PLXNB1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "644" }, { "type": "GeneCombination", "id": "636" }, { "type": "GeneCombination", "id": "646" }, { "type": "GeneCombination", "id": "651" }, { "type": "GeneCombination", "id": "654" }, { "type": "GeneCombination", "id": "655" }, { "type": "GeneCombination", "id": "665" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PLXNB1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PLXNB1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PLXNB1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }