Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/917/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GBA", "attributes": { "go_molecular_function": [ "['glucosyltransferase activity', 'steryl-beta-glucosidase activity', 'protein binding', 'glucosylceramidase activity', 'signaling receptor binding', 'scavenger receptor binding']" ], "pathway_id": [ "kegg_path:hsa00511", "kegg_path:hsa00600", "kegg_path:hsa01100", "kegg_path:hsa04142", "kegg_path:hsa00511", "kegg_path:hsa00600", "kegg_path:hsa01100", "kegg_path:hsa04142", "R-HSA-1430728", "R-HSA-1660662", "R-HSA-390466", "R-HSA-390471", "R-HSA-391251", "R-HSA-392499", "R-HSA-428157", "R-HSA-556833", "kegg_path:hsa00511", "kegg_path:hsa00600", "kegg_path:hsa01100", "kegg_path:hsa04142", "kegg_path:hsa00511", "kegg_path:hsa00600", "kegg_path:hsa01100", "kegg_path:hsa04142", "R-HSA-1430728", "R-HSA-1660662", "R-HSA-390466", "R-HSA-390471", "R-HSA-391251", "R-HSA-392499", "R-HSA-428157", "R-HSA-556833" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "A0A0G2JLB3", "ensembl_id": "None", "entrez_id": "None", "chromosome_number": "1", "lastmodified": "2023-05-16T12:02:32.731054" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2751" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GBA/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GBA/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "916" }, { "type": "GeneCombination", "id": "917" }, { "type": "GeneCombination", "id": "918" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GBA/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GBA/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GBA/?format=api" } }, { "type": "Gene", "id": "PRKN", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'kinase binding', 'actin binding', 'protein binding', 'transcription corepressor activity', 'identical protein binding', 'ubiquitin protein ligase activity', 'SH3 domain binding', 'tubulin binding', 'ubiquitin binding', 'chaperone binding', 'cullin family protein binding', 'ubiquitin conjugating enzyme binding', 'heat shock protein binding', 'Hsp70 protein binding', 'G protein-coupled receptor binding', 'F-box domain binding', 'beta-catenin binding', 'PDZ domain binding', 'phospholipase binding', 'ubiquitin protein ligase binding', 'ubiquitin-protein transferase activity', 'protein kinase binding', 'enzyme binding', 'protein-containing complex binding', 'ubiquitin-specific protease binding', 'histone deacetylase binding']" ], "pathway_id": [ "kegg_path:hsa04120", "kegg_path:hsa04137", "kegg_path:hsa04141", "kegg_path:hsa05012", "kegg_path:hsa05014", "kegg_path:hsa05022", "R-HSA-1280218", "R-HSA-1632852", "R-HSA-168256", "R-HSA-392499", "R-HSA-5205647", "R-HSA-5205685", "R-HSA-5688426", "R-HSA-5689877", "R-HSA-597592", "R-HSA-9612973", "R-HSA-9646399", "R-HSA-9663891", "R-HSA-977225", "R-HSA-983168", "R-HSA-983169" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O60260", "ensembl_id": "None", "entrez_id": "ENSG00000185345", "chromosome_number": "6", "lastmodified": "2021-10-18T11:00:44.312064" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "266" }, { "type": "CopyNumberVariant", "id": "445" }, { "type": "CopyNumberVariant", "id": "446" }, { "type": "SmallVariant", "id": "262" }, { "type": "SmallVariant", "id": "265" }, { "type": "SmallVariant", "id": "268" }, { "type": "SmallVariant", "id": "440" }, { "type": "SmallVariant", "id": "442" }, { "type": "SmallVariant", "id": "2752" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PRKN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PRKN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "96" }, { "type": "GeneCombination", "id": "917" }, { "type": "GeneCombination", "id": "918" }, { "type": "GeneCombination", "id": "919" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PRKN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PRKN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PRKN/?format=api" } }, { "type": "Gene", "id": "TARDBP", "attributes": { "go_molecular_function": [ "['RNA polymerase II cis-regulatory region sequence-specific DNA binding', \"mRNA 3'-UTR binding\", 'pre-mRNA intronic binding', 'double-stranded DNA binding', 'protein binding', 'RNA binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa05014", "kegg_path:hsa05022" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13148", "ensembl_id": "None", "entrez_id": "ENSG00000120948", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.778821" }, "relationships": { "variant_set": { "meta": { "count": 12 }, "data": [ { "type": "SmallVariant", "id": "540" }, { "type": "SmallVariant", "id": "871" }, { "type": "SmallVariant", "id": "932" }, { "type": "SmallVariant", "id": "1430" }, { "type": "SmallVariant", "id": "1695" }, { "type": "SmallVariant", "id": "1704" }, { "type": "SmallVariant", "id": "2750" }, { "type": "SmallVariant", "id": "3060" }, { "type": "SmallVariant", "id": "3416" }, { "type": "SmallVariant", "id": "3440" }, { "type": "SmallVariant", "id": "3444" }, { "type": "SmallVariant", "id": "3607" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TARDBP/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TARDBP/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 13 }, "data": [ { "type": "GeneCombination", "id": "183" }, { "type": "GeneCombination", "id": "271" }, { "type": "GeneCombination", "id": "295" }, { "type": "GeneCombination", "id": "452" }, { "type": "GeneCombination", "id": "916" }, { "type": "GeneCombination", "id": "917" }, { "type": "GeneCombination", "id": "919" }, { "type": "GeneCombination", "id": "553" }, { "type": "GeneCombination", "id": "1027" }, { "type": "GeneCombination", "id": "1128" }, { "type": "GeneCombination", "id": "1146" }, { "type": "GeneCombination", "id": "1155" }, { "type": "GeneCombination", "id": "1157" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TARDBP/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TARDBP/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TARDBP/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }