Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/542/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CELSR2", "attributes": { "go_molecular_function": [ "G protein-coupled receptor activity", "transmembrane signaling receptor activity", "calcium ion binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9HCU4", "ensembl_id": "ENSG00000143126", "entrez_id": "1952", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.972153" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "1519" }, { "type": "SmallVariant", "id": "1536" }, { "type": "SmallVariant", "id": "1617" }, { "type": "SmallVariant", "id": "1623" }, { "type": "SmallVariant", "id": "1650" }, { "type": "SmallVariant", "id": "1665" }, { "type": "SmallVariant", "id": "1691" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "488" }, { "type": "GeneCombination", "id": "490" }, { "type": "GeneCombination", "id": "493" }, { "type": "GeneCombination", "id": "509" }, { "type": "GeneCombination", "id": "520" }, { "type": "GeneCombination", "id": "523" }, { "type": "GeneCombination", "id": "525" }, { "type": "GeneCombination", "id": "535" }, { "type": "GeneCombination", "id": "536" }, { "type": "GeneCombination", "id": "542" }, { "type": "GeneCombination", "id": "551" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR2/?format=api" } }, { "type": "Gene", "id": "NOS1", "attributes": { "go_molecular_function": [ "calcium-dependent protein binding", "FMN binding", "nitric-oxide synthase activity", "flavin adenine dinucleotide binding", "calmodulin binding", "oxidoreductase activity" ], "pathway_id": [ "kegg_path:hsa01100", "kegg_path:hsa04730", "kegg_path:hsa00330", "kegg_path:hsa04713", "kegg_path:hsa04970", "R-HSA-5578775", "kegg_path:hsa00220", "kegg_path:hsa04926", "kegg_path:hsa05014", "kegg_path:hsa04713", "kegg_path:hsa04970", "kegg_path:hsa00330", "kegg_path:hsa01100", "kegg_path:hsa04730", "kegg_path:hsa00220", "kegg_path:hsa05022", "kegg_path:hsa04371", "kegg_path:hsa04145", "kegg_path:hsa05010", "kegg_path:hsa04926", "kegg_path:hsa05014", "R-HSA-109582", "R-HSA-397014", "R-HSA-1222556", "kegg_path:hsa04020", "kegg_path:hsa01100", "kegg_path:hsa04730", "R-HSA-168249", "kegg_path:hsa04020", "kegg_path:hsa00330", "kegg_path:hsa04713", "kegg_path:hsa04970", "kegg_path:hsa04926", "kegg_path:hsa05014", "R-HSA-168256", "kegg_path:hsa04371", "kegg_path:hsa05022", "kegg_path:hsa00220", "R-HSA-5576891", "kegg_path:hsa05010", "kegg_path:hsa04145", "kegg_path:hsa04371", "R-HSA-392154", "R-HSA-418346", "kegg_path:hsa05022", "kegg_path:hsa04145", "kegg_path:hsa05010", "kegg_path:hsa04020" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P29475", "ensembl_id": "ENSG00000089250", "entrez_id": "4842", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.332724" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "907" }, { "type": "SmallVariant", "id": "1666" }, { "type": "SmallVariant", "id": "1866" }, { "type": "SmallVariant", "id": "1925" }, { "type": "SmallVariant", "id": "1947" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "283" }, { "type": "GeneCombination", "id": "542" }, { "type": "GeneCombination", "id": "620" }, { "type": "GeneCombination", "id": "650" }, { "type": "GeneCombination", "id": "660" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOS1/?format=api" } }, { "type": "Gene", "id": "SHROOM2", "attributes": { "go_molecular_function": [ "protein binding", "actin filament binding", "beta-catenin binding", "ligand-gated sodium channel activity", "actin binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q13796", "ensembl_id": "ENSG00000146950", "entrez_id": "357", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.447214" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1594" }, { "type": "SmallVariant", "id": "1636" }, { "type": "SmallVariant", "id": "1667" }, { "type": "SmallVariant", "id": "2232" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHROOM2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "529" }, { "type": "GeneCombination", "id": "542" }, { "type": "GeneCombination", "id": "757" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHROOM2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }