Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/589/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CACNA1S", "attributes": { "go_molecular_function": [ "metal ion binding", "protein binding", "voltage-gated ion channel activity", "voltage-gated calcium channel activity", "high voltage-gated calcium channel activity", "ion channel activity", "calcium channel activity", "calmodulin binding" ], "pathway_id": [ "kegg_path:hsa04261", "kegg_path:hsa04911", "kegg_path:hsa04927", "kegg_path:hsa04935", "kegg_path:hsa04270", "kegg_path:hsa04912", "kegg_path:hsa04929", "kegg_path:hsa04260", "kegg_path:hsa05412", "kegg_path:hsa04727", "kegg_path:hsa05410", "kegg_path:hsa05010", "kegg_path:hsa05020", "kegg_path:hsa04921", "kegg_path:hsa04726", "kegg_path:hsa05414", "kegg_path:hsa04010", "kegg_path:hsa04020", "R-HSA-419037", "kegg_path:hsa04723", "kegg_path:hsa04024", "kegg_path:hsa04925", "kegg_path:hsa05022", "kegg_path:hsa04924", "kegg_path:hsa04022", "kegg_path:hsa04725", "R-HSA-375165", "R-HSA-9675108", "R-HSA-422475", "kegg_path:hsa04934", "R-HSA-1266738" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13698", "ensembl_id": "ENSG00000081248", "entrez_id": "779", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.729240" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1193" }, { "type": "SmallVariant", "id": "1782" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA1S/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CACNA1S/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "382" }, { "type": "GeneCombination", "id": "589" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA1S/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CACNA1S/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CACNA1S/?format=api" } }, { "type": "Gene", "id": "HMBS", "attributes": { "go_molecular_function": [ "hydroxymethylbilane synthase activity", "protein binding", "transferase activity" ], "pathway_id": [ "kegg_path:hsa00860", "kegg_path:hsa01100", "R-HSA-189445", "R-HSA-189451", "R-HSA-1430728", "kegg_path:hsa01240" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P08397", "ensembl_id": "ENSG00000256269", "entrez_id": "3145", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.253957" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "335" }, { "type": "SmallVariant", "id": "1775" }, { "type": "SmallVariant", "id": "1781" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HMBS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HMBS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "118" }, { "type": "GeneCombination", "id": "587" }, { "type": "GeneCombination", "id": "589" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HMBS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HMBS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HMBS/?format=api" } }, { "type": "Gene", "id": "NDUFS8", "attributes": { "go_molecular_function": [ "['NADH dehydrogenase (ubiquinone) activity', '4 iron, 4 sulfur cluster binding', 'protein binding', 'metal ion binding', 'NADH dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00190", "kegg_path:hsa01100", "kegg_path:hsa04714", "kegg_path:hsa04723", "kegg_path:hsa04932", "kegg_path:hsa05010", "kegg_path:hsa05012", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05020", "kegg_path:hsa05022", "R-HSA-1428517", "R-HSA-1430728", "R-HSA-163200", "R-HSA-611105", "R-HSA-6799198" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O00217", "ensembl_id": "None", "entrez_id": "ENSG00000110717", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.566766" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1783" }, { "type": "SmallVariant", "id": "1784" }, { "type": "SmallVariant", "id": "3357" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NDUFS8/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NDUFS8/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "589" }, { "type": "GeneCombination", "id": "1129" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NDUFS8/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NDUFS8/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NDUFS8/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }