Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/735/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FKBP10", "attributes": { "go_molecular_function": [ "peptidyl-prolyl cis-trans isomerase activity", "calcium ion binding", "protein binding", "FK506 binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "None", "ensembl_id": "ENSG00000141756", "entrez_id": "60681", "chromosome_number": "17", "lastmodified": "2022-08-04T14:14:58.218796" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2135" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FKBP10/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FKBP10/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "735" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FKBP10/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FKBP10/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FKBP10/?format=api" } }, { "type": "Gene", "id": "NBAS", "attributes": { "go_molecular_function": [ "protein binding", "SNARE binding" ], "pathway_id": [ "R-HSA-6811434", "R-HSA-199991", "R-HSA-5653656", "R-HSA-6811442", "R-HSA-8856688" ], "essential_gene": null, "status": "CU", "uniprot_acc": "A2RRP1", "ensembl_id": "ENSG00000151779", "entrez_id": "51594", "chromosome_number": "2", "lastmodified": "2022-08-04T14:14:58.285633" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2137" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NBAS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NBAS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "735" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NBAS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NBAS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NBAS/?format=api" } }, { "type": "Gene", "id": "NEK1", "attributes": { "go_molecular_function": [ "['protein tyrosine kinase activity', 'protein serine kinase activity', 'protein serine/threonine/tyrosine kinase activity', 'protein binding', 'protein kinase activity', 'protein serine/threonine kinase activity', '14-3-3 protein binding', 'metal ion binding', 'kinase activity', 'ATP binding']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q96PY6", "ensembl_id": "None", "entrez_id": "ENSG00000137601", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.841783" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "976" }, { "type": "SmallVariant", "id": "1369" }, { "type": "SmallVariant", "id": "1814" }, { "type": "SmallVariant", "id": "2052" }, { "type": "SmallVariant", "id": "2056" }, { "type": "SmallVariant", "id": "2062" }, { "type": "SmallVariant", "id": "2085" }, { "type": "SmallVariant", "id": "2096" }, { "type": "SmallVariant", "id": "2132" }, { "type": "SmallVariant", "id": "2138" }, { "type": "SmallVariant", "id": "2188" }, { "type": "SmallVariant", "id": "2190" }, { "type": "SmallVariant", "id": "2191" }, { "type": "SmallVariant", "id": "2193" }, { "type": "SmallVariant", "id": "2194" }, { "type": "SmallVariant", "id": "2196" }, { "type": "SmallVariant", "id": "2198" }, { "type": "SmallVariant", "id": "3352" }, { "type": "SmallVariant", "id": "3414" }, { "type": "SmallVariant", "id": "3425" }, { "type": "SmallVariant", "id": "3427" }, { "type": "SmallVariant", "id": "3430" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NEK1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NEK1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "748" }, { "type": "GeneCombination", "id": "749" }, { "type": "GeneCombination", "id": "313" }, { "type": "GeneCombination", "id": "428" }, { "type": "GeneCombination", "id": "599" }, { "type": "GeneCombination", "id": "600" }, { "type": "GeneCombination", "id": "707" }, { "type": "GeneCombination", "id": "708" }, { "type": "GeneCombination", "id": "711" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "734" }, { "type": "GeneCombination", "id": "747" }, { "type": "GeneCombination", "id": "735" }, { "type": "GeneCombination", "id": "1128" }, { "type": "GeneCombination", "id": "1145" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NEK1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NEK1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NEK1/?format=api" } }, { "type": "Gene", "id": "TBX5", "attributes": { "go_molecular_function": [ "protein binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "DNA binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "DNA-binding transcription factor activity", "RNA polymerase II-specific DNA-binding transcription factor binding", "sequence-specific DNA binding", "RNA polymerase II cis-regulatory region sequence-specific DNA binding" ], "pathway_id": [ "R-HSA-397014", "R-HSA-212436", "R-HSA-5578768", "R-HSA-2032785", "R-HSA-73857", "R-HSA-5576891", "R-HSA-74160" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q99593", "ensembl_id": "ENSG00000089225", "entrez_id": "6910", "chromosome_number": "12", "lastmodified": "2022-08-04T14:15:00.033669" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2139" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TBX5/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TBX5/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "735" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TBX5/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TBX5/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TBX5/?format=api" } }, { "type": "Gene", "id": "TRIP11", "attributes": { "go_molecular_function": [ "protein binding", "transcription coactivator activity", "small GTPase binding" ], "pathway_id": [ "R-HSA-1643685", "R-HSA-5617833", "R-HSA-1852241", "R-HSA-5663202", "R-HSA-5620924", "R-HSA-5653656", "R-HSA-6811442", "R-HSA-6811438", "R-HSA-9682385", "R-HSA-9703465", "R-HSA-199991" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15643", "ensembl_id": "ENSG00000100815", "entrez_id": "9321", "chromosome_number": "14", "lastmodified": "2022-08-04T14:14:59.319997" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2136" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TRIP11/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TRIP11/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "735" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TRIP11/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TRIP11/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TRIP11/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }