Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/547/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ADGRA3", "attributes": { "go_molecular_function": [ "G protein-coupled receptor activity", "protein binding", "transmembrane signaling receptor activity" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8IWK6", "ensembl_id": "ENSG00000152990", "entrez_id": "166647", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:45.000925" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1598" }, { "type": "SmallVariant", "id": "1633" }, { "type": "SmallVariant", "id": "1679" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADGRA3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADGRA3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "514" }, { "type": "GeneCombination", "id": "528" }, { "type": "GeneCombination", "id": "547" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADGRA3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADGRA3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ADGRA3/?format=api" } }, { "type": "Gene", "id": "CELSR1", "attributes": { "go_molecular_function": [ "['G protein-coupled receptor activity', 'calcium ion binding']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NYQ6", "ensembl_id": "None", "entrez_id": "ENSG00000075275", "chromosome_number": "22", "lastmodified": "2021-10-18T11:00:44.610366" }, "relationships": { "variant_set": { "meta": { "count": 18 }, "data": [ { "type": "SmallVariant", "id": "3114" }, { "type": "SmallVariant", "id": "1073" }, { "type": "SmallVariant", "id": "1075" }, { "type": "SmallVariant", "id": "1077" }, { "type": "SmallVariant", "id": "1081" }, { "type": "SmallVariant", "id": "1481" }, { "type": "SmallVariant", "id": "1486" }, { "type": "SmallVariant", "id": "1517" }, { "type": "SmallVariant", "id": "1552" }, { "type": "SmallVariant", "id": "1630" }, { "type": "SmallVariant", "id": "1678" }, { "type": "SmallVariant", "id": "3103" }, { "type": "SmallVariant", "id": "3105" }, { "type": "SmallVariant", "id": "3107" }, { "type": "SmallVariant", "id": "3109" }, { "type": "SmallVariant", "id": "3111" }, { "type": "SmallVariant", "id": "3112" }, { "type": "SmallVariant", "id": "3116" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 13 }, "data": [ { "type": "GeneCombination", "id": "351" }, { "type": "GeneCombination", "id": "352" }, { "type": "GeneCombination", "id": "473" }, { "type": "GeneCombination", "id": "475" }, { "type": "GeneCombination", "id": "487" }, { "type": "GeneCombination", "id": "499" }, { "type": "GeneCombination", "id": "527" }, { "type": "GeneCombination", "id": "538" }, { "type": "GeneCombination", "id": "547" }, { "type": "GeneCombination", "id": "1040" }, { "type": "GeneCombination", "id": "1041" }, { "type": "GeneCombination", "id": "1043" }, { "type": "GeneCombination", "id": "1042" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR1/?format=api" } }, { "type": "Gene", "id": "COBL", "attributes": { "go_molecular_function": [ "actin monomer binding", "actin binding", "protein binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O75128", "ensembl_id": "ENSG00000106078", "entrez_id": "23242", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.994636" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1554" }, { "type": "SmallVariant", "id": "1604" }, { "type": "SmallVariant", "id": "1659" }, { "type": "SmallVariant", "id": "1674" }, { "type": "SmallVariant", "id": "1681" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COBL/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COBL/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "499" }, { "type": "GeneCombination", "id": "515" }, { "type": "GeneCombination", "id": "539" }, { "type": "GeneCombination", "id": "545" }, { "type": "GeneCombination", "id": "547" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COBL/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COBL/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COBL/?format=api" } }, { "type": "Gene", "id": "CUBN", "attributes": { "go_molecular_function": [ "signaling receptor activity", "cobalamin binding", "cargo receptor activity", "calcium ion binding", "metal ion binding" ], "pathway_id": [ "R-HSA-174824", "R-HSA-382551", "R-HSA-1430728", "R-HSA-3359462", "R-HSA-556833", "R-HSA-3359463", "R-HSA-3296482", "R-HSA-1643685", "R-HSA-196849", "kegg_path:hsa04977", "R-HSA-196854", "R-HSA-8964011", "R-HSA-196741", "R-HSA-3296469", "R-HSA-5668914", "R-HSA-8957322", "R-HSA-8964043", "R-HSA-196791" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O60494", "ensembl_id": "ENSG00000107611", "entrez_id": "8029", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.733343" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "1516" }, { "type": "SmallVariant", "id": "1524" }, { "type": "SmallVariant", "id": "1563" }, { "type": "SmallVariant", "id": "1601" }, { "type": "SmallVariant", "id": "1609" }, { "type": "SmallVariant", "id": "1677" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CUBN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CUBN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "487" }, { "type": "GeneCombination", "id": "489" }, { "type": "GeneCombination", "id": "503" }, { "type": "GeneCombination", "id": "515" }, { "type": "GeneCombination", "id": "518" }, { "type": "GeneCombination", "id": "547" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CUBN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CUBN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CUBN/?format=api" } }, { "type": "Gene", "id": "SCRIB", "attributes": { "go_molecular_function": [], "pathway_id": [ "kegg_path:hsa05203", "R-HSA-4086400", "kegg_path:hsa04390", "kegg_path:hsa05165", "R-HSA-3858494", "kegg_path:hsa04530", "R-HSA-4608870", "kegg_path:hsa05165", "kegg_path:hsa04390", "kegg_path:hsa04390", "kegg_path:hsa05165", "kegg_path:hsa05203", "kegg_path:hsa04530", "R-HSA-195721", "R-HSA-162582", "kegg_path:hsa04530", "R-HSA-195721", "R-HSA-162582", "kegg_path:hsa05165", "kegg_path:hsa04390", "kegg_path:hsa05203", "R-HSA-4086400", "kegg_path:hsa04530", "R-HSA-4608870", "R-HSA-3858494", "kegg_path:hsa05203" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q14160", "ensembl_id": "ENSG00000180900", "entrez_id": "23513", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.361258" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "1074" }, { "type": "SmallVariant", "id": "1076" }, { "type": "SmallVariant", "id": "1078" }, { "type": "SmallVariant", "id": "1082" }, { "type": "SmallVariant", "id": "1535" }, { "type": "SmallVariant", "id": "1588" }, { "type": "SmallVariant", "id": "1592" }, { "type": "SmallVariant", "id": "1616" }, { "type": "SmallVariant", "id": "1682" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SCRIB/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SCRIB/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "351" }, { "type": "GeneCombination", "id": "353" }, { "type": "GeneCombination", "id": "492" }, { "type": "GeneCombination", "id": "511" }, { "type": "GeneCombination", "id": "512" }, { "type": "GeneCombination", "id": "519" }, { "type": "GeneCombination", "id": "547" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SCRIB/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SCRIB/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SCRIB/?format=api" } }, { "type": "Gene", "id": "SNX13", "attributes": { "go_molecular_function": [ "phosphatidylinositol binding", "lipid binding", "phosphatidylinositol-3-phosphate binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9Y5W8", "ensembl_id": "ENSG00000071189", "entrez_id": "23161", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.761516" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1596" }, { "type": "SmallVariant", "id": "1680" }, { "type": "SmallVariant", "id": "1692" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SNX13/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SNX13/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "513" }, { "type": "GeneCombination", "id": "547" }, { "type": "GeneCombination", "id": "551" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SNX13/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SNX13/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SNX13/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 6 } }