Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/369/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FGF4", "attributes": { "go_molecular_function": [ "fibroblast growth factor receptor binding", "heparin binding", "growth factor activity" ], "pathway_id": [ "R-HSA-5654741", "kegg_path:hsa04151", "R-HSA-1643685", "R-HSA-190239", "R-HSA-1839130", "R-HSA-190236", "kegg_path:hsa04020", "R-HSA-74752", "R-HSA-162582", "kegg_path:hsa04010", "R-HSA-5654219", "R-HSA-5655302", "R-HSA-5684996", "kegg_path:hsa05200", "R-HSA-5654227", "R-HSA-1839124", "R-HSA-190241", "R-HSA-190322", "R-HSA-5654726", "R-HSA-5654736", "R-HSA-5654716", "R-HSA-5663202", "R-HSA-190373", "R-HSA-190375", "R-HSA-2033514", "R-HSA-5654221", "R-HSA-5654733", "R-HSA-5654689", "R-HSA-5654696", "R-HSA-112399", "R-HSA-74751", "kegg_path:hsa05226", "R-HSA-1839122", "R-HSA-190242", "R-HSA-5654712", "R-HSA-109704", "R-HSA-2404192", "R-HSA-5654688", "R-HSA-5654732", "kegg_path:hsa04810", "R-HSA-2219528", "R-HSA-1226099", "R-HSA-5654695", "R-HSA-5654699", "kegg_path:hsa05224", "R-HSA-5654727", "kegg_path:hsa05218", "R-HSA-5654720", "R-HSA-5654719", "R-HSA-5654700", "R-HSA-5654706", "R-HSA-1257604", "R-HSA-5654710", "R-HSA-9006925", "R-HSA-5654687", "R-HSA-5673001", "kegg_path:hsa04014", "R-HSA-5683057", "R-HSA-2428928", "R-HSA-6811558", "R-HSA-5655332", "R-HSA-8853338", "R-HSA-5655253", "R-HSA-5654738", "R-HSA-5654743", "R-HSA-5654704", "R-HSA-5654228", "R-HSA-5654693", "R-HSA-190372", "R-HSA-2219530", "R-HSA-1839126", "R-HSA-2428924", "kegg_path:hsa04015", "R-HSA-199418", "R-HSA-5654708", "R-HSA-2033519", "R-HSA-5658623", "R-HSA-9006934" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P08620", "ensembl_id": "ENSG00000075388", "entrez_id": "2249", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.256110" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1153" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGF4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGF4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "369" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGF4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGF4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FGF4/?format=api" } }, { "type": "Gene", "id": "FGFR3", "attributes": { "go_molecular_function": [ "['protein tyrosine kinase activity', 'protein serine/threonine/tyrosine kinase activity', 'transmembrane receptor protein tyrosine kinase activity', 'protein binding', 'fibroblast growth factor-activated receptor activity', 'fibroblast growth factor binding', 'identical protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04144", "kegg_path:hsa04151", "kegg_path:hsa04550", "kegg_path:hsa04810", "kegg_path:hsa05200", "kegg_path:hsa05206", "kegg_path:hsa05219", "kegg_path:hsa05230", "R-HSA-1226099", "R-HSA-1643685", "R-HSA-1839130", "R-HSA-2033514", "R-HSA-2033515", "R-HSA-5655332", "R-HSA-5663202", "R-HSA-8853334", "R-HSA-8853338", "kegg_path:hsa01521", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04144", "kegg_path:hsa04151", "kegg_path:hsa04550", "kegg_path:hsa04810", "kegg_path:hsa05200", "kegg_path:hsa05206", "kegg_path:hsa05219", "kegg_path:hsa05230" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P22607", "ensembl_id": "None", "entrez_id": "ENSG00000068078", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.500473" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1152" }, { "type": "SmallVariant", "id": "3209" }, { "type": "SmallVariant", "id": "3276" }, { "type": "SmallVariant", "id": "3333" }, { "type": "SmallVariant", "id": "3700" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGFR3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "369" }, { "type": "GeneCombination", "id": "1072" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1124" }, { "type": "GeneCombination", "id": "1252" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGFR3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR3/?format=api" } }, { "type": "Gene", "id": "RERE", "attributes": { "go_molecular_function": [ "protein binding", "transcription coactivator activity", "transcription corepressor activity", "sequence-specific DNA binding", "metal ion binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9P2R6", "ensembl_id": "ENSG00000142599", "entrez_id": "473", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.426219" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1154" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RERE/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RERE/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "369" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RERE/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RERE/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RERE/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }