Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/347/genes/?format=api
{ "data": [ { "type": "Gene", "id": "LDLR", "attributes": { "go_molecular_function": [ "low-density lipoprotein particle receptor activity" ], "pathway_id": [ "kegg_path:hsa04925", "kegg_path:hsa05145", "kegg_path:hsa04976", "R-HSA-6806667", "R-HSA-162582", "R-HSA-372790", "kegg_path:hsa04934", "R-HSA-174824", "kegg_path:hsa04927", "kegg_path:hsa05160", "kegg_path:hsa04144", "kegg_path:hsa04913", "R-HSA-418594", "R-HSA-975634", "R-HSA-199991", "R-HSA-8964026", "kegg_path:hsa04979", "kegg_path:hsa04144", "kegg_path:hsa04913", "kegg_path:hsa04979", "R-HSA-388396", "kegg_path:hsa04934", "R-HSA-8964043", "R-HSA-8856825", "R-HSA-8964038", "kegg_path:hsa04927", "kegg_path:hsa05160", "R-HSA-2187338", "kegg_path:hsa04976", "kegg_path:hsa05145", "R-HSA-382551", "R-HSA-1430728", "kegg_path:hsa04925", "R-HSA-5653656", "R-HSA-8856828", "R-HSA-196854" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P01130", "ensembl_id": "ENSG00000130164", "entrez_id": "3949", "chromosome_number": "19", "lastmodified": "2021-10-18T11:00:44.498869" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1063" }, { "type": "SmallVariant", "id": "1800" }, { "type": "SmallVariant", "id": "1803" }, { "type": "SmallVariant", "id": "1804" }, { "type": "SmallVariant", "id": "1805" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LDLR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LDLR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "347" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LDLR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LDLR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LDLR/?format=api" } }, { "type": "Gene", "id": "PCSK9", "attributes": { "go_molecular_function": [ "very-low-density lipoprotein particle binding", "apolipoprotein receptor binding", "protein binding", "low-density lipoprotein particle receptor binding", "apolipoprotein binding", "serine-type endopeptidase activity", "low-density lipoprotein particle binding", "very-low-density lipoprotein particle receptor binding", "RNA binding", "protein self-association", "signaling receptor inhibitor activity", "sodium channel inhibitor activity" ], "pathway_id": [ "R-HSA-392499", "R-HSA-381426", "R-HSA-597592", "R-HSA-8964043", "R-HSA-8964038", "R-HSA-8866427", "R-HSA-174824", "R-HSA-382551", "R-HSA-8957275", "kegg_path:hsa04979" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8NBP7", "ensembl_id": "ENSG00000169174", "entrez_id": "255738", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.626222" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "992" }, { "type": "SmallVariant", "id": "1064" }, { "type": "SmallVariant", "id": "1801" }, { "type": "SmallVariant", "id": "1802" }, { "type": "SmallVariant", "id": "2582" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PCSK9/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PCSK9/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "317" }, { "type": "GeneCombination", "id": "347" }, { "type": "GeneCombination", "id": "860" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PCSK9/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PCSK9/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PCSK9/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }