Gene Combination Instance – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genecombinations/669/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": {
        "type": "GeneCombination",
        "id": "669",
        "attributes": {
            "gene_relationship": [
                "Relevant pathways for phenotype"
            ],
            "protein_interactions": [],
            "common_pathways": [
                "MAPK family signaling cascades",
                "EGFR tyrosine kinase inhibitor resistance",
                "Central carbon metabolism in cancer",
                "PD-L1 expression and PD-1 checkpoint pathway in cancer",
                "Intracellular signaling by second messengers",
                "Gene expression (Transcription)",
                "Proteoglycans in cancer",
                "Focal adhesion",
                "secretion and action",
                "PIP3 activates AKT signaling",
                "Signaling by Receptor Tyrosine Kinases",
                "PP2A and IER3 Regulate PI3K/AKT Signaling",
                "Generic Transcription Pathway",
                "ErbB signaling pathway",
                "Ras signaling pathway",
                "Melanoma",
                "Choline metabolism in cancer",
                "Calcium signaling pathway",
                "Pancreatic cancer",
                "Hepatocellular carcinoma",
                "MAPK signaling pathway",
                "JAK-STAT signaling pathway",
                "RAF/MAP kinase cascade",
                "RNA Polymerase II Transcription",
                "Glioma",
                "Constitutive Signaling by Aberrant PI3K in Cancer",
                "Gastric cancer",
                "HIF-1 signaling pathway",
                "Breast cancer",
                "MAPK1/MAPK3 signaling",
                "Colorectal cancer",
                "Immune System",
                "Phospholipase D signaling pathway",
                "PI3K/AKT Signaling in Cancer",
                "Pathways in cancer",
                "MicroRNAs in cancer",
                "Negative regulation of the PI3K/AKT network",
                "Prostate cancer",
                "Disease",
                "Diseases of signal transduction by growth factor receptors and second messengers",
                "Growth hormone synthesis",
                "Human papillomavirus infection",
                "Non-small cell lung cancer",
                "PI5P",
                "Rap1 signaling pathway",
                "PI3K-Akt signaling pathway",
                "Signal Transduction"
            ],
            "genecomb_metascore": 0,
            "lastmodified": "2021-10-18T11:01:22.021795"
        },
        "relationships": {
            "combination_set": {
                "meta": {
                    "count": 1
                },
                "data": [
                    {
                        "type": "Combination",
                        "id": "OLI906"
                    }
                ],
                "links": {
                    "self": "https://olida.ibsquare.be/api/genecombinations/669/relationships/combination_set?format=api",
                    "related": "https://olida.ibsquare.be/api/genecombinations/669/combinations/?format=api"
                }
            },
            "genes": {
                "meta": {
                    "count": 4
                },
                "data": [
                    {
                        "type": "Gene",
                        "id": "EGF"
                    },
                    {
                        "type": "Gene",
                        "id": "GHR"
                    },
                    {
                        "type": "Gene",
                        "id": "MET"
                    },
                    {
                        "type": "Gene",
                        "id": "MTOR"
                    }
                ],
                "links": {
                    "self": "https://olida.ibsquare.be/api/genecombinations/669/relationships/genes?format=api",
                    "related": "https://olida.ibsquare.be/api/genecombinations/669/genes/?format=api"
                }
            }
        },
        "links": {
            "self": "https://olida.ibsquare.be/api/genecombinations/669/?format=api"
        }
    }
}