Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1193/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CDH23", "attributes": { "go_molecular_function": [ "['calcium ion binding', 'protein binding', 'cadherin binding']" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9H251", "ensembl_id": "None", "entrez_id": "ENSG00000107736", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.400908" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "208" }, { "type": "SmallVariant", "id": "217" }, { "type": "SmallVariant", "id": "223" }, { "type": "SmallVariant", "id": "508" }, { "type": "SmallVariant", "id": "510" }, { "type": "SmallVariant", "id": "511" }, { "type": "SmallVariant", "id": "518" }, { "type": "SmallVariant", "id": "520" }, { "type": "SmallVariant", "id": "521" }, { "type": "SmallVariant", "id": "658" }, { "type": "SmallVariant", "id": "719" }, { "type": "SmallVariant", "id": "746" }, { "type": "SmallVariant", "id": "753" }, { "type": "SmallVariant", "id": "758" }, { "type": "SmallVariant", "id": "1055" }, { "type": "SmallVariant", "id": "1284" }, { "type": "SmallVariant", "id": "2234" }, { "type": "SmallVariant", "id": "2240" }, { "type": "SmallVariant", "id": "2390" }, { "type": "SmallVariant", "id": "2870" }, { "type": "SmallVariant", "id": "3543" }, { "type": "SmallVariant", "id": "3551" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CDH23/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CDH23/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 17 }, "data": [ { "type": "GeneCombination", "id": "81" }, { "type": "GeneCombination", "id": "75" }, { "type": "GeneCombination", "id": "79" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "171" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "345" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "814" }, { "type": "GeneCombination", "id": "813" }, { "type": "GeneCombination", "id": "812" }, { "type": "GeneCombination", "id": "810" }, { "type": "GeneCombination", "id": "1193" }, { "type": "GeneCombination", "id": "1195" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CDH23/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CDH23/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CDH23/?format=api" } }, { "type": "Gene", "id": "CDHR1", "attributes": { "go_molecular_function": [ "['molecular_function', 'calcium ion binding']" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "A0A0A6YYA3", "ensembl_id": "None", "entrez_id": "ENSG00000148600", "chromosome_number": "10", "lastmodified": "2024-02-29T15:02:20.550920" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3544" }, { "type": "SmallVariant", "id": "3552" }, { "type": "SmallVariant", "id": "3578" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CDHR1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CDHR1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "1193" }, { "type": "GeneCombination", "id": "1195" }, { "type": "GeneCombination", "id": "1204" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CDHR1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CDHR1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CDHR1/?format=api" } }, { "type": "Gene", "id": "CPSF3", "attributes": { "go_molecular_function": [ "[\"5'-3' exonuclease activity\", 'endoribonuclease activity', 'protein binding', 'RNA binding', \"5'-3' exoribonuclease activity\", 'metal ion binding']" ], "pathway_id": [ "kegg_path:hsa03015", "R-HSA-159231", "R-HSA-159234", "R-HSA-72163", "R-HSA-72172", "R-HSA-72187", "R-HSA-72202", "R-HSA-72203", "R-HSA-73856", "R-HSA-73857", "R-HSA-74160", "R-HSA-75067", "R-HSA-77595", "R-HSA-8953854" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9UKF6", "ensembl_id": "None", "entrez_id": "ENSG00000119203", "chromosome_number": "2", "lastmodified": "2024-02-29T15:02:20.543579" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3542" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CPSF3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CPSF3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1193" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CPSF3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CPSF3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CPSF3/?format=api" } }, { "type": "Gene", "id": "EML6", "attributes": { "go_molecular_function": [ "['microtubule binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q6ZMW3", "ensembl_id": "None", "entrez_id": "ENSG00000214595", "chromosome_number": "2", "lastmodified": "2024-02-29T15:02:20.536547" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3540" }, { "type": "SmallVariant", "id": "3568" }, { "type": "SmallVariant", "id": "3584" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EML6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EML6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "1193" }, { "type": "GeneCombination", "id": "1202" }, { "type": "GeneCombination", "id": "1207" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EML6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EML6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/EML6/?format=api" } }, { "type": "Gene", "id": "SLC4A4", "attributes": { "go_molecular_function": [ "['protein binding', 'transmembrane transporter activity', 'symporter activity', 'inorganic anion exchanger activity', 'sodium:bicarbonate symporter activity', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04964", "kegg_path:hsa04972", "kegg_path:hsa04976", "R-HSA-1643685", "R-HSA-382551", "R-HSA-425381", "R-HSA-425393", "R-HSA-425407", "R-HSA-5619054", "R-HSA-5619102", "R-HSA-5619115" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9Y6R1", "ensembl_id": "None", "entrez_id": "ENSG00000080493", "chromosome_number": "4", "lastmodified": "2024-02-29T15:02:20.540146" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3541" }, { "type": "SmallVariant", "id": "3567" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC4A4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC4A4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1193" }, { "type": "GeneCombination", "id": "1201" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLC4A4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLC4A4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SLC4A4/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }